Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Gonul Velicelebi"'
Autor:
Clemens R. Scherzer, G.Bernhard Landwehrmeyer, Julie A. Kerner, David G. Standaert, Zane R. Hollingsworth, Lorrie P. Daggett, Gönül Veliçelebi, John B. Penney, Jr., Anne B. Young
Publikováno v:
Neurobiology of Disease, Vol 4, Iss 1, Pp 35-46 (1997)
We have used a quantitativein situhybridization method with human ribonucleotide probes to examine the regional and cellular distribution ofN-methyl-d-aspartate receptor (NMDAR) subunit mRNAs in the human cerebellum. Purkinje cells showed very dense
Externí odkaz:
https://doaj.org/article/d11cc9b8468c40a4a780e439ed95a9e5
Autor:
Karunya Ramasamy, K. David Becker, Bradley T. Hyman, T J Moscarillo, Gonul Velicelebi, Christoph Lange, Martin Ingelsson, Steven L. Wagner, Kristina Mullin, Michele Parkinson, Lars Bertram, Monica Y. Hsiao, Rashmi Menon, Deborah Blacker, Andrew J. Sampson, Kathryn J. Elliott, Mikko Hiltunen, Rudolph E. Tanzi
Publikováno v:
New England Journal of Medicine. 352:884-894
background Recent analyses suggest that the known Alzheimer’s disease genes account for less than half the genetic variance in this disease. The gene encoding ubiquilin 1 ( UBQLN1 ) is one of several candidate genes for Alzheimer’s disease locate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5324547be70de73673be4f8e80b110
https://doi.org/10.1056/nejmoa042765
https://doi.org/10.1056/nejmoa042765
Autor:
Kathryn J. Elliott, Kenneth A. Stauderman, Gonul Velicelebi, Alison Gillespie, Tadimeti S. Rao, Brian O. Claeps, Michael M. Harpold, Laura E. Chavez-Noriega, Edwin C. Johnson, R. T. Reid, Janis Corey-Naeve, James H. Crona
Publikováno v:
Neuropharmacology. 39:2543-2560
HEK293 cells were stably transfected with the cDNAs encoding full-length human neuronal nicotinic acetylcholine receptor (nAChR) subunit combinations alpha3beta2 or alpha4beta2. [(3)H]-(+/-)Epibatidine ([(3)H]-(+/-)EPI) bound to membranes from A3B2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87413d6ed3b894ca7163a2df1fe320d5
https://doi.org/10.1016/s0028-3908(00)00134-9
https://doi.org/10.1016/s0028-3908(00)00134-9
Autor:
J. B. Penney, Gonul Velicelebi, Christoph M. Kosinski, T J Counihan, Clemens R. Scherzer, David G. Standaert, Lorrie P. Daggett, G B Landwehrmeyer, Anne B. Young, J A Kerner
Publikováno v:
The Journal of Comparative Neurology. 390:63-74
N-methyl-D-aspartate receptors (NRs) play an important role in basal ganglia function. By using in situ hybridization with ribonucleotide probes, we investigated the regional and cellular distribution of NR subunit mRNA expression in the human basal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e86330d0e83f519225f17dd006ea5d7f
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<63::aid-cne6>3.0.co
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<63::aid-cne6>3.0.co
Autor:
Clemens R. Scherzer, T J Counihan, G B Landwehrmeyer, Gonul Velicelebi, J. B. Penney, Christoph M. Kosinski, David G. Standaert, Lorrie P. Daggett, Anne B. Young
Publikováno v:
The Journal of Comparative Neurology. 390:91-101
Evidence is accumulating that glutamate-mediated excitotoxicity plays an important role in neuronal degeneration in Parkinson's disease (PD). In addition, alterations in excitatory amino acid neurotransmission in the basal ganglia contribute to the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae3867fd793773c68b92d037196eadf
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<91::aid-cne8>3.0.co
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<91::aid-cne8>3.0.co
Expression of N-Methyl-D-Aspartate receptor subunit mRNAs in the human brain: Hippocampus and cortex
Autor:
G B Landwehrmeyer, J. B. Penney, T J Counihan, Anne B. Young, David G. Standaert, Lorrie P. Daggett, Gonul Velicelebi, Clemens R. Scherzer, Christoph M. Kosinski, J A Kerner
Publikováno v:
The Journal of Comparative Neurology. 390:75-90
N-methyl-D-aspartate receptor (NR) activation in the hippocampus and neocortex plays a central role in memory and cognitive function. We analyzed the cellular expression of the five NR subunit (NR1 and NR2A-D) mRNAs in these regions with in situ hybr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4cabf42c8271f14274ac2b52d050201
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<75::aid-cne7>3.0.co
https://doi.org/10.1002/(sici)1096-9861(19980105)390:1<75::aid-cne7>3.0.co
Autor:
Lorrie P. Daggett, Peter J. Flor, J A Kerner, Rainer Kuhn, Anne B. Young, Aida I. Sacaan, David G. Standaert, F.-F. Lin, Gonul Velicelebi, C. Jachec, Mark A. Varney, Sara P. Rao
Publikováno v:
Neuropharmacology. 36:917-931
We isolated and characterized a cDNA encoding the human metabotropic glutamate receptor subtype 1b (hmGluR1b). In situ hybridization studies in human brain regions revealed a higher distribution of mGluR1 mRNA in the dentate gyrus of the hippocampus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5afcfb231ef05175c7d3420cc0542c60
https://doi.org/10.1016/s0028-3908(97)00078-6
https://doi.org/10.1016/s0028-3908(97)00078-6
Autor:
Kathryn J. Elliott, Gonul Velicelebi, Steven B. Ellis, Michael M. Harpold, Arturo Urrutia, Edwin C. Johnson, Kelly J. Berckhan, Laura E. Chavez-Noriega
Publikováno v:
Journal of Molecular Neuroscience. 7:217-228
cDNA clones encoding human neuronal nicotinic acetylcholine receptor α2, α3, α4, α5, α6, α7, β2, β3, and β4 subunits were isolated from brainstem, hippocampus, prefrontal cortex, substantia nigra, thalamus, and IMR32 libraries. Human α2 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bff0c52832f5977a69509bbf43dc3689
https://doi.org/10.1007/bf02736842
https://doi.org/10.1007/bf02736842
Autor:
Sangram S. Sisodia, Rudolph E. Tanzi, Chengzhi Yu, Anne M. Danks, Soan Cheng, Gonul Velicelebi, Kenneth A. Stauderman, Kwangwook Ahn, Yue-Ming Li, Elizabeth J. Ackerman, Dan Comer, Paul J. Digregorio, Phuong T. Nguyen, William T. Comer, Long Mao, David P. M. Pleynet, Xulun Zhang, Maria Z. Kounnas, Steven L. Wagner, William C. Mobley, Curtis M. Tyree
Alzheimer's disease (AD) is characterized pathologically by the abundance of senile plaques and neurofibrillary tangles in the brain. We synthesized over 1200 novel gamma-secretase modulator (GSM) compounds that reduced Abeta(42) levels without inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e0cce1c4de406c2d5b743c7ab53d04
https://europepmc.org/articles/PMC2947312/
https://europepmc.org/articles/PMC2947312/
Autor:
Gonul Velicelebi, Sally Provow
Publikováno v:
Regulatory Peptides. 28:71-82
Limited proteolysis was used to probe and compare the conformation of the rat lung vasoactive intestinal peptide (VIP) receptor in membrane-bound and detergent-solubilized states. It had been shown previously that the activity of the detergent-solubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b19dd2334e8ead90badede079598874
https://doi.org/10.1016/0167-0115(90)90065-5
https://doi.org/10.1016/0167-0115(90)90065-5