Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gongyuan Yu"'
Publikováno v:
Cardiovascular Research. 50:56-64
Objective: Stimulation of A3 adenosine receptors has been shown to protect cardiac myocytes from ischemic injury, but the mechanism of this action is unknown. We evaluated the effect of adenosine agonists and antagonists on the sarcoplasmic reticulum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0e8c7c529c35bb1eef9c6ec22cda6a
https://doi.org/10.1016/s0008-6363(00)00318-7
https://doi.org/10.1016/s0008-6363(00)00318-7
Publikováno v:
British Journal of Pharmacology. 131:342-348
1. The use of anthraquinone antineoplastic agents is limited by their cardiac toxicity, which is largely due to activation of the sarcoplasmic reticulum (SR) Ca(2+) release channel (ryanodine receptor). MEN 10755 is a new disaccharide analogue of dox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d7fdad85abb296ca1165c8feb7a9b6e
https://doi.org/10.1038/sj.bjp.0703575
https://doi.org/10.1038/sj.bjp.0703575
Autor:
Gongyuan Yu, Giovanni Ronca, Riccardo Zucchi, Mario Mariani, Paola Galbani, Simonetta Ronca-Testoni
Publikováno v:
Circulation Research. 83:908-915
Abstract —We investigated the effect of sulfhydryl and disulfide reagents on ischemic preconditioning and on sarcoplasmic reticulum Ca 2+ release. Isolated working rat hearts were subjected to ischemic preconditioning (three 3-minute periods of glo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af4a4d19880075ad4c30cdbbae8ff4e
https://doi.org/10.1161/01.res.83.9.908
https://doi.org/10.1161/01.res.83.9.908
Autor:
Giovanni Ronca, Riccardo Zucchi, Gongyuan Yu, Simonetta Ronca-Testoni, Paola Galbani, Mario Mariani, Ugo Limbruno
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
We investigated the effect of gallopamil on cardiac sarcoplasmic reticulum (SR) function. Heavy SR was prepared from bovine ventricular muscle. Oxalate-supported calcium uptake was stimulated by gallopamil at concentrations ranging from 10 to 300 nM,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1550f83f247ab5e10451619523cda948
https://doi.org/10.1097/00005344-199200207-00003
https://doi.org/10.1097/00005344-199200207-00003
Publikováno v:
Basic research in cardiology. 95(2)
Cytosolic Ca2+ overload plays a major role in the development of irreversible injury during myocardial ischemia. Such overload is due at least in part to the release of Ca2+ from the sarcoplasmic reticulum. Therefore, we investigated whether dantrole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bd0b924de80dd5dcb5c1eb9eb5f102
https://pubmed.ncbi.nlm.nih.gov/10826506
https://pubmed.ncbi.nlm.nih.gov/10826506
Autor:
G Bosco, Riccardo Zucchi, Mario Mariani, Giovanni Ronca, Antonio M. Calafiore, Sabina Gallina, Pericle Di Napoli, Antonio Barsotti, Simonetta Ronca-Testoni, Gongyuan Yu
We evaluated the effect of ischemia and reperfusion on sarcoplasmic reticulum Ca uptake in patients subjected to cardiac surgery. Our series included 16 patients (seven female, nine male, age 63 +/- 2 years): five were subjected to aortic valve repla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7f7c20e077e95ce3dbe77d2c84b60d
http://hdl.handle.net/11568/176240
http://hdl.handle.net/11568/176240
Autor:
Paola Galbani, Simonetta Ronca-Testoni, Giovanni Ronca, Mario Mariani, Riccardo Zucchi, Gongyuan Yu
Publikováno v:
Circulation research. 76(6)
Abstract We investigated the modifications of cardiac ryanodine receptors/sarcoplasmic reticulum Ca 2+ release channels occurring in ischemic preconditioning. In an isolated rat heart model, the injury produced by 30 minutes of global ischemia was re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3869f7a00a8882f25a35fd1e2e12fa
https://pubmed.ncbi.nlm.nih.gov/7758159
https://pubmed.ncbi.nlm.nih.gov/7758159
Autor:
Simonetta Ronca-Testoni, Paola Galbani, Mario Mariani, Riccardo Zucchi, Gongyuan Yu, Giovanni Ronca
Publikováno v:
Scopus-Elsevier
1. In a sarcoplasmic reticulum fraction obtained from rat hearts, the analysis of equilibrium [3H]-ryanodine binding showed high and low affinity sites (KD = 1.3 nM and 2.8 microM, Bmax = 2.2 pmol mg-1 and 27.8 pmol mg-1). The dissociation rate const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a8b19aff3ec1ef4e093d630f645a66
https://pubmed.ncbi.nlm.nih.gov/7712034
https://pubmed.ncbi.nlm.nih.gov/7712034
Autor:
Paola Galbani, Giovanni Ronca, Simonetta Ronca-Testoni, Gongyuan Yu, Riccardo Zucchi, Mario Mariani
Objective: We investigated the effect of ischemia on cardiac dihydropyridine receptors, which correspond to L-type sarcolemmal calcium channels. Methods: Isolated working rat hearts were perfused aerobically for 10 min, and then subjected to 10–60
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43a404eed19747f4b3b395856ded8d2
http://hdl.handle.net/11568/174566
http://hdl.handle.net/11568/174566
Autor:
Gongyuan Yu, Simonetta Ronca-Testoni, Riccardo Zucchi, Mario Mariani, Giovanni Ronca, Paola Galbani
Publikováno v:
Circulation research. 74(2)
We investigated the effect of ischemia and reperfusion on the cardiac ryanodine receptor, which corresponds to the sarcoplasmic reticulum Ca2+ channel. Isolated working rat hearts were subjected to 10 to 30 minutes of global ischemia, followed or not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b4baeef63e84720f1ecfd26d51f248
https://pubmed.ncbi.nlm.nih.gov/8293566
https://pubmed.ncbi.nlm.nih.gov/8293566