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Akademický článek

AZD5438 a GSK-3a/b and CDK inhibitor is antiapoptotic modulates mitochondrial activity and protects human neurons from mitochondrial toxins

Autor: Gongyu Shi, Helen Scott, Nur Izzah Farhana Mohamad Azhar, Andriana Gialeli, Benjamin Clennell, Keng Siang Lee, Jenny Hurcombe, Daniel Whitcomb, Richard Coward, Liang-Fong Wong, Oscar Cordero-Llana, James B. Uney

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)

Abstract We previously reported that kenpaullone, which inhibits GSK-3a/b and CDKs inhibited CCCP mediated mitochondrial depolarisation and augments the mitochondrial network. To investigate the actions of this class of drug further, we compared the

Externí odkaz: https://doaj.org/article/0a873f3846674100ba0b71629afe0b9b

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Abnormal scaffold attachment factor 1 expression and localization in spinocerebellar ataxias and Huntington’s chorea

Autor: Andriana Gialeli, Nicola Buckner, Liang-Fong Wong, Kevin C Kemp, Caroline A Rivers, Nicholas D. Allen, Helen L. Scott, Alastair Wilkins, Gongyu Shi, James B. Uney, Oscar Cordero-Llana

Publikováno v: Buckner, N, Kemp, K C, Scott, H L, Shi, G, Rivers, C A, Gialeli, A, Wong, L-F, Cordero Llana, O, Allen, N, Wilkins, A & Uney, J B 2020, ' Abnormal scaffold attachment factor 1 expression and localisation in spinocerebellar ataxias and huntington’s chorea ', Brain Pathology . https://doi.org/10.1111/bpa.12872
Brain Pathology

SAFB1 is a DNA and RNA binding protein that is highly expressed in the cerebellum and hippocampus and is involved in the processing of coding and non‐coding RNAs, splicing and dendritic function. We analyzed SAFB1 expression in the post‐mortem br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d387dc2887fc0c2ce93f5d7fbe5b591
https://doi.org/10.1111/bpa.12872

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