Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Gongqiang Wu"'
Publikováno v:
Cell Transplantation, Vol 33 (2024)
Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary immunotherapy that has shown significant success in treating certain hematologic malignancies. However, there are still challenges and limitations associated with this therapy, and not
Externí odkaz:
https://doaj.org/article/338c0c01ff8c478d98ff6a49ea37574c
Publikováno v:
Cancer Medicine, Vol 13, Iss 19, Pp n/a-n/a (2024)
ABSTRACT Background Chimeric antigen receptor (CAR)‐T‐cell therapy has transformed cancer treatment, leading to remarkable clinical outcomes. However, resistance continues to be a major obstacle, significantly limiting its efficacy in numerous pa
Externí odkaz:
https://doaj.org/article/dd32bd6176fd4740b70025d67e26d4d9
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e34951- (2024)
Leukemia is a kind of hematopoietic stem cell malignant clonal disease. Drug therapy is the core treatment strategy for leukemia, but the current therapeutic drugs have defects such as low bioavailability, large adverse reactions and inconvenient int
Externí odkaz:
https://doaj.org/article/5abbbfcad8574625bb5d44b74849a4d7
Autor:
Wen Lei, Ai Zhao, Hui Liu, Chunmei Yang, Cheng Wei, Shanshan Guo, Zhilu Chen, Qunyi Guo, Linjie Li, Mingzhe Zhao, Gongqiang Wu, Guifang Ouyang, Ming Liu, Jinyi Zhang, Jimin Gao, Wenbin Qian
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Although CD19-specific chimeric antigen receptor (CAR) T cells are curative for patients with relapsed or refractory large B-cell lymphoma (R/R LBCL), disease relapse with tumor antigen-positive remains a challenge. Cytokine/chemokine-expres
Externí odkaz:
https://doaj.org/article/cfcb19c9c9bd4e5d8b7f347d75b7e0b5
Autor:
Yunyi Wu, Yanchun Li, Yan Gao, Ping Zhang, Qiangan Jing, Yinhao Zhang, Weidong Jin, Ying Wang, Jing Du, Gongqiang Wu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 171, Iss , Pp 116132- (2024)
Acute myeloid leukemia (AML) is a prevalent hematological malignancy that exhibits a wide array of molecular abnormalities. Although traditional treatment modalities such as chemotherapy and allogeneic stem cell transplantation (HSCT) have become sta
Externí odkaz:
https://doaj.org/article/4aad620cdff741988d91a23c84c859bc
Autor:
Jing Yang, Feifan Jin, Huanjuan Li, Yuhuan Shen, Weilin Shi, Lina Wang, Lei Zhong, Gongqiang Wu, Qiaoliang Wu, Yanchun Li
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-21 (2023)
Abstract Stomach adenocarcinoma (STAD) is the third leading cause of cancer-related deaths and the fifth most prevalent malignancy worldwide. Mitochondrial respiratory chain complexes play a crucial role in STAD pathogenesis. However, how mitochondri
Externí odkaz:
https://doaj.org/article/76c600e532e74d69916c3fbc46573090
Autor:
Tao Lei, Gongqiang Wu, Yongjin Xu, Weihao Zhuang, Jialiang Lu, Shuiyun Han, Yuxin Zhuang, Xiaowu Dong, Haiyan Yang
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Double-hit or Triple-hit lymphoma (DHL/THL) is a subset of high-grade B cell lymphoma harboring rearrangements of MYC and BCL2 and/or BCL6, and usually associate with aggressive profile, while current therapies tend to provide poo
Externí odkaz:
https://doaj.org/article/2dbf8554888b4cdea67054bedf874749
Autor:
Xiaozhen Liu, Huifang Jiang, Guifang Ouyang, Shujuan Zhou, Jiang Huang, Jin Zhang, Caifang Zhao, Yanping Shao, Gongqiang Wu, Xibin Xiao, Chen Mei, Gaixiang Xu, Liya MA, Xinping Zhou, Yanling Ren, Hongyan Tong
Publikováno v:
HemaSphere, Vol 7, p e82508fa (2023)
Externí odkaz:
https://doaj.org/article/3ce320e302b84d5f9cb8b4c83de27234
Autor:
Gongqiang Wu, Shanshan Guo, Qian Luo, Xiaoxia Wang, Wenhai Deng, Guifang Ouyang, Jeffrey J. Pu, Wen Lei, Wenbin Qian
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundsChimeric antigen receptor (CAR)-T cell therapy has achieved unprecedented success in treating hematopoietic malignancies. However, this cell therapy is hampered in treating acute myeloid leukemia (AML) due to lack of ideal cell surface tar
Externí odkaz:
https://doaj.org/article/3260b2b5281b48bab460a6f107e6fca3
Autor:
Wen Lei, Shibing Wang, Nengwen Xu, Yu Chen, Gongqiang Wu, Aibin Zhang, Xiaomin Chen, Yin Tong, Wenbin Qian
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 125, Iss , Pp 110030- (2020)
Different strategies were taken to make virotherapy more effective at killing cancer cells. Among them, oncolytic virus which arms the therapeutic gene to enhance antitumor activity is a prevalent approach. In this study, a newly developed oncolytic
Externí odkaz:
https://doaj.org/article/7a94ffc4c82945e8a07085bb9ae11f73