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Akademický článek

Role of Lactate Dehydrogenase in Tumor Metabolism and Progress of LDH-targeted Drugs

Autor: QIU Jinmei, GONG Juan, XIE Qingchi, XIE Zhizhong

Publikováno v: Zhongliu Fangzhi Yanjiu, Vol 47, Iss 12, Pp 980-985 (2020)

Abnormal energy metabolism is one of the main hallmarks of cancer. Studies have shown that tumor cells, even in the presence of oxygen, favored glycolysis to produce lactic acid and a small amount of ATP with the help of LDHA in the cytosol (the famo

Externí odkaz: https://doaj.org/article/8cfc7c6bae3c4fe6aeda3604c1b04434

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Akademický článek

Co-downregulation of GRP78 and GRP94 induces apoptosis and inhibits migration in prostate cancer cells

Autor: Lu Tong, Wang Yue, Xu Kang, Zhou Zhijun, Gong Juan, Zhang Yingang, Gong Hua, Dai Qiang, Yang Jun, Xiong Biao, Song Ze, Yang Gang

Publikováno v: Open Life Sciences, Vol 14, Iss 1, Pp 384-391 (2019)

Both glucose-regulated protein 78 kDa (GRP78) and glucose-regulated protein 94 kDa (GRP94) are important molecular chaperones that play critical roles in maintaining tumor survival and progression. This study investigated the effects in prostate canc

Externí odkaz: https://doaj.org/article/1a08831fc3d9473b9603250cfee3508d

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Attention Weighted Mixture of Experts with Contrastive Learning for Personalized Ranking in E-commerce

Autor: Gong, Juan, Chen, Zhenlin, Ma, Chaoyi, Xiao, Zhuojian, Wang, Haonan, Tang, Guoyu, Liu, Lin, Xu, Sulong, Long, Bo, Jiang, Yunjiang

Ranking model plays an essential role in e-commerce search and recommendation. An effective ranking model should give a personalized ranking list for each user according to the user preference. Existing algorithms usually extract a user representatio

Externí odkaz: http://arxiv.org/abs/2306.05011