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Akademický článek

Data analyses of honokiol-induced autophagy of human glioma cells in vitro and in vivo

Autor: Gong-Jhe Wu, Chien-Ju Lin, Yung-Wei Lin, Ruei-Ming Chen

Publikováno v: Data in Brief, Vol 9, Iss C, Pp 667-672 (2016)

This article contains raw and processed data related to a research, “Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway” (C.J. Lin, T.L. Chen,

Externí odkaz: https://doaj.org/article/98891fb2bd944229a1fac3afa27ce3ab

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Akademický článek

Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells

Autor: Gong-Jhe Wu, Sun-Ta Yang, Ruei-Ming Chen

Publikováno v: Molecules, Vol 25, Iss 6, p 1450 (2020)

Temozolomide (TMZ)-induced chemoresistance to human glioblastomas is a critical challenge now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houpo), can kill human glioblastoma cells and suppresses

Externí odkaz: https://doaj.org/article/3032826c85824b4cb490e48070d2f600

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Naringin Improves Osteoblast Mineralization and Bone Healing and Strength through Regulating Estrogen Receptor Alpha-Dependent Alkaline Phosphatase Gene Expression

Autor: Jr-Di Yang, Shing-Hwa Liu, Ruei Ming Chen, Kung-Yen Chen, Gong-Jhe Wu

Publikováno v: Journal of Agricultural and Food Chemistry. 69:13020-13033

Phytoestrogens are strongly recommended for treating osteoporosis. Our previous study showed that naringin, a citrus flavonoid, can enhance the bone mass in ovariectomized rats. In this study, we further elucidated the mechanisms of naringin-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329d203569b8d0af1e04e811096baa89
https://doi.org/10.1021/acs.jafc.1c04353

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Genistein Triggers Translocation of Estrogen Receptor-Alpha in Mitochondria to Induce Expressions of ATP Synthesis-Associated Genes and Improves Energy Production and Osteoblast Maturation

Autor: Ruei Ming Chen, Chuen Chau Chang, Yih Giun Cherng, Shing-Hwa Liu, Jui Tai Chen, Gong Jhe Wu

Publikováno v: The American Journal of Chinese Medicine. 49:901-923

Our previous study showed that estrogen can induce mitochondrial adenosine triphosphate (ATP) synthesis-associated gene expressions and osteoblast maturation. Genistein, a phytoestrogenic isoflavone that is widely found in various foods and tradition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07cf7b32a93ac9a6a3c01206144b594b
https://doi.org/10.1142/s0192415x21500439

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Akademický článek

Mechanical stretch via transforming growth factor-β1 activates microRNA-208a to regulate hypertrophy in cultured rat cardiac myocytes

Autor: Bao-Wei Wang, Gong-Jhe Wu, Wen-Pin Cheng, Kou-Gi Shyu

Publikováno v: Journal of the Formosan Medical Association, Vol 112, Iss 10, Pp 635-643 (2013)

MicroRNA-208a (miR208a) and mechanical stress play a key role in cardiac hypertrophy. The relationship between miR208a and mechanical stress in cultured cardiomyocytes has not been investigated. The molecular mechanisms underlying miR208a-induced hyp

Externí odkaz: https://doaj.org/article/6ba56d9529114cb09b05b4181093f3d0

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Akademický článek

MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart.

Autor: Bao-Wei Wang, Gong-Jhe Wu, Wen-Ping Cheng, Kou-Gi Shyu

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84188 (2014)

MicroRNA-208a (mir-208a) is essential for cardiac hypertrophy and fibrosis. Endoglin, a co-receptor of transforming growth factor-β is also essential for cardiac fibrosis. Endoglin has been shown to be a target of mir-208a in the in vitro mechanical

Externí odkaz: https://doaj.org/article/54dc06999a9c4ea7a2d3fa5aad1edd92

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Genistein Improves Bone Healing via Triggering Estrogen Receptor Alpha-Mediated Expressions of Osteogenesis-Associated Genes and Consequent Maturation of Osteoblasts

Autor: Shing-Hwa Liu, Yih Giun Cherng, Chuen Chau Chang, Ruei Ming Chen, Gong Jhe Wu, Jui Tai Chen

Publikováno v: Journal of agricultural and food chemistry. 68(39)

Osteoporosis-associated fractures may cause higher morbidity and mortality. Our previous study showed the effects of genistein, a phytoestrogen, on the induction of estrogen receptor alpha (ERα) gene expression and stimulation of osteoblast minerali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32c0530f17f2905ad8bf90bd3bc9e97
https://pubmed.ncbi.nlm.nih.gov/32897066

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Inhibition of the estrogen receptor alpha signaling delays bone regeneration and alters osteoblast maturation, energy metabolism, and angiogenesis

Autor: Gong Jhe Wu, Yih Giun Cherng, Shun Tai Yang, Pei I. Lin, Jui Tai Chen, Ruei Ming Chen

Publikováno v: Life sciences. 258

Aims The estrogen-ERα axis participates in osteoblast maturation. This study was designed to further evaluated the roles of the estrogen-ERα axis in bone healing and the possible mechanisms. Main methods Female ICR mice were created a metaphyseal b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1410ada95c910021758f3c362fc2799f
https://pubmed.ncbi.nlm.nih.gov/32781073

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Sepsis-induced liver dysfunction was ameliorated by propofol via suppressing hepatic lipid peroxidation, inflammation, and drug interactions

Autor: Yuan Wen Lee, Hsiao Chien Tsai, Gong Jhe Wu, Ruei Ming Chen, Yung Wei Lin, Jui Tai Chen

Publikováno v: Life Sciences. 213:279-286

Aims Our previous study showed that propofol can protect against sepsis-induced insults through suppressing liver nitrosation and inflammation. This study further evaluated the mechanisms of propofol-caused protection from sepsis-induced liver dysfun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d3a722104e36732953bad6457720a0e
https://doi.org/10.1016/j.lfs.2018.10.038

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Protection of Dexmedetomidine Against Ischemia/Reperfusion-Induced Apoptotic Insults to Neuronal Cells Occurs Via an Intrinsic Mitochondria-Dependent Pathway

Autor: Shing-Hwa Liu, Ta Liang Chen, Hsiao Chien Tsai, Jui Tai Chen, Gong Jhe Wu, Ruei Ming Chen

Publikováno v: Journal of Cellular Biochemistry. 118:2635-2644

Dexmedetomidine, an agonist of alpha2-adrenergic receptors, is used for critically ill patients to induce and maintain sedation and analgesia. Brain ischemia/reperfusion (I/R) usually causes severe neuronal injuries to intensive care unit patients. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bcaf81073b1f6b2a1f7f4ec49041ff9
https://doi.org/10.1002/jcb.25847

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