Host genetic background is a barrier to broadly effective vaccine-mediated protection against tuberculosis.

Autor: Lai R; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Gong DN; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Williams T; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Ogunsola AF; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Cavallo K; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Lindestam Arlehamn CS; Center for infectious disease and vaccine research, La Jolla Institute for Immunology, La Jolla, California, USA., Acolatse S; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Beamer GL; Texas Biomedical Research Institute, San Antonio, Texas, USA., Ferris MT; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Sassetti CM; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA., Behar SM; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Jul 03; Vol. 133 (13). Date of Electronic Publication: 2023 Jul 03.