Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Gong‐Hong Wei"'
Autor:
Xinpei Ci, Sujun Chen, Rui Zhu, Mojgan Zarif, Rahi Jain, Wangyuan Guo, Matthew Ramotar, Linsey Gong, Wenjie Xu, Olivia Singh, Sheila Mansouri, Gelareh Zadeh, Gong-Hong Wei, Wei Xu, Robert Bristow, Alejandro Berlin, Marianne Koritzinsky, Theodorus van der Kwast, Housheng Hansen He
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Tumor hypoxia is associated with prostate cancer (PCa) treatment resistance and poor prognosis. Pimonidazole (PIMO) is an investigational hypoxia probe used in clinical trials. A better understanding of the clinical significance a
Externí odkaz:
https://doaj.org/article/0536003d350a4933803620ed43e2f7a7
Autor:
Mengjie Zhong, Wenjie Xu, Pan Tian, Qin Zhang, Zixian Wang, Limiao Liang, Qixiang Zhang, Yuehong Yang, Ying Lu, Gong‐Hong Wei
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Genetic and epigenetic alterations are cancer hallmark characteristics. However, the role of inherited cancer predisposition alleles in co‐opting lineage factor epigenetic reprogramming and tumor progression remains elusive. Here the FinnG
Externí odkaz:
https://doaj.org/article/52b2215bb66f4b908aa3592e93dfdd0d
Autor:
Hui Chen, Zeyang Wang, Lihai Gong, Qixuan Wang, Wenyan Chen, Jia Wang, Xuelian Ma, Ruofan Ding, Xing Li, Xudong Zou, Mireya Plass, Cheng Lian, Ting Ni, Gong-Hong Wei, Wei Li, Lin Deng, Lei Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Alternative polyadenylation plays an important role in cancer initiation and progression; however, current transcriptome-wide association studies mostly ignore alternative polyadenylation when identifying putative cancer susceptibility genes
Externí odkaz:
https://doaj.org/article/fe6125469ca4482c8ff5d07d8b71d5c4
Autor:
Yong Zeng, Rahi Jain, Magnus Lam, Musaddeque Ahmed, Haiyang Guo, Wenjie Xu, Yuan Zhong, Gong-Hong Wei, Wei Xu, Housheng Hansen He
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background Expression quantitative trait locus (eQTL) analysis has emerged as an important tool in elucidating the link between genetic variants and gene expression, thereby bridging the gap between risk SNPs and associated diseases. We rece
Externí odkaz:
https://doaj.org/article/ddab9b98b99f4849a657d1ce5da1b112
Autor:
Sara P. Cruz, Qin Zhang, Raman Devarajan, Christos Paia, Binjie Luo, Kai Zhang, Saara Koivusalo, Longguang Qin, Jihan Xia, Anne Ahtikoski, Markku Vaarala, Tomasz Wenta, Gong‐Hong Wei, Aki Manninen
Publikováno v:
Advanced Science, Vol 11, Iss 11, Pp n/a-n/a (2024)
Abstract The extracellular matrix (ECM) undergoes substantial changes during prostate cancer (PCa) progression, thereby regulating PCa growth and invasion. Herein, a meta‐analysis of multiple PCa cohorts is performed which revealed that downregulat
Externí odkaz:
https://doaj.org/article/8122d00339f94410a874a0dfe4629d49
Autor:
Xiayun Yang, Qin Zhang, Shuxuan Li, Raman Devarajan, Binjie Luo, Zenglai Tan, Zixian Wang, Nikolaos Giannareas, Tomasz Wenta, Wenlong Ma, Yuqing Li, Yuehong Yang, Aki Manninen, Song Wu, Gong-Hong Wei
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-30 (2023)
Abstract Background Aberrant somatic genomic alteration including copy number amplification is a hallmark of cancer genomes. We previously profiled genomic landscapes of prostate cancer (PCa), yet the underlying causal genes with prognostic potential
Externí odkaz:
https://doaj.org/article/5ac07c8f5fb64b55b03685f77c3dbda4
Autor:
Le Li, Xing Zeng, Zheng Chao, Jing Luo, Wei Guan, Qiang Zhang, Yue Ge, Yanan Wang, Zezhong Xiong, Sheng Ma, Qiang Zhou, Junbiao Zhang, Jihua Tian, David Horne, Bertram Yuh, Zhiquan Hu, Gong‐Hong Wei, Baojun Wang, Xu Zhang, Peixiang Lan, Zhihua Wang
Publikováno v:
Advanced Science, Vol 10, Iss 27, Pp n/a-n/a (2023)
Abstract The Warburg effect‐related metabolic dysfunction of the tricarboxylic acid (TCA) cycle has emerged as a hallmark of various solid tumors, particularly renal cell carcinoma (RCC). RCC is characterized by high immune infiltration and thus re
Externí odkaz:
https://doaj.org/article/407d7273c52643ac8a473ac44a636bd1
Autor:
Nan Xu, Yunpeng Ren, Yufang Bao, Xianfeng Shen, Jiahui Kang, Ning Wang, Zixian Wang, Xinlu Han, Zhen Li, Ji Zuo, Gong-Hong Wei, Zefeng Wang, Wei-Xing Zong, Wen Liu, Gangcai Xie, Yongbo Wang
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113041- (2023)
Summary: Alternative splicing (AS) has been implicated in cell cycle regulation and cancer, but the underlying mechanisms are poorly understood. The poly(U)-binding splicing factor 60 (PUF60) is essential for embryonic development and is overexpresse
Externí odkaz:
https://doaj.org/article/1ef40e336c8946e18565b17d958acc33
Autor:
Nikolaos Giannareas, Qin Zhang, Xiayun Yang, Rong Na, Yijun Tian, Yuehong Yang, Xiaohao Ruan, Da Huang, Xiaoqun Yang, Chaofu Wang, Peng Zhang, Aki Manninen, Liang Wang, Gong-Hong Wei
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
The role of risk loci identified from genome-wide association studies in prostate cancer (PCa) progression remains poorly characterised. Here, the authors report enrichment of transcription factor genes within PCa risk-associated regions and germline
Externí odkaz:
https://doaj.org/article/68a5e6cf0a8e452ea0ab96cfa23424cf
Autor:
Xueyou Ma, Zenglai Tan, Qin Zhang, Kaifang Ma, Jun Xiao, Xiong Wang, Yanan Wang, Mengjie Zhong, Yu Wang, Jing Li, Xing Zeng, Wei Guan, Shaogang Wang, Kan Gong, Gong-Hong Wei, Zhihua Wang
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-20 (2022)
Abstract Background Von Hippel-Lindau (VHL) disease is an autosomal dominant genetic neoplastic disorder caused by germline mutation or deletion of the VHL gene, characterized by the tendency to develop multisystem benign or malignant tumors. The mec
Externí odkaz:
https://doaj.org/article/f1f7673fb6024cb1ad02a3a75e5d07e3