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pro vyhledávání: '"Gong, Chaojun"'
Deep generative models have gained significant advancements to accelerate drug discovery by generating bioactive chemicals against desired targets. Nevertheless, most generated compounds that have been validated for potent bioactivity often exhibit s
Externí odkaz:
http://arxiv.org/abs/2401.01059
Autor:
Gong Chaojun, Fajun Nan, Fei Chen, Yi Chen, Yi Su, Ting He, Qianqian Shen, Shu-Wei Zhang, Yangming Zhang, Jian Ding, Mingbo Su, Jia Li
Publikováno v:
Journal of Medicinal Chemistry. 63:804-815
A series of bisthiazole-based hydroxamic acids as novel potent HDAC inhibitors was developed during our previous work. In the present work, a new series of highly potent bisthiazole-based compounds were designed and synthesized. Among the prepared co
Autor:
Li Sheng, Yangming Zhang, Jia Li, Fei Chen, Fajun Nan, Gong Chaojun, Anhui Gao, Yubo Zhou, Mingbo Su, Jing-Ya Li
Publikováno v:
European Journal of Medicinal Chemistry. 112:81-90
Histone deacetylases (HDACs) are a class of epigenetic modulators with complex functions in histone post-translational modifications and are well known targets for antineoplastic drugs. We have previously developed a series of bisthiazole-based hydro