Importance of receptor expression in the classification of novel ligands at the M 2 muscarinic acetylcholine receptor.

Autor: Jiang Y; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Yeasmin M; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Gondin AB; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Burger WAC; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Jul; Vol. 181 (14), pp. 2338-2350. Date of Electronic Publication: 2023 Jan 20.

Selective G protein signaling driven by substance P-neurokinin receptor dynamics.

Autor: Harris JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, CA, USA., Faust B; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA.; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.; Biophysics Graduate Program, University of California, San Francisco, CA, USA., Gondin AB; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Dämgen MA; Department of Computer Science, Stanford University, Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA., Suomivuori CM; Department of Computer Science, Stanford University, Stanford, CA, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA., Veldhuis NA; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash University, Parkville, Victoria, Australia., Cheng Y; Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA. Yifan.Cheng@ucsf.edu.; Howard Hughes Medical Institute, University of California, San Francisco, CA, USA. Yifan.Cheng@ucsf.edu., Dror RO; Department of Computer Science, Stanford University, Stanford, CA, USA. ron.dror@stanford.edu.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. ron.dror@stanford.edu.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. ron.dror@stanford.edu.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, USA. ron.dror@stanford.edu., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. david.thal@monash.edu., Manglik A; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA, USA. Aashish.Manglik@ucsf.edu.; Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA. Aashish.Manglik@ucsf.edu.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2022 Jan; Vol. 18 (1), pp. 109-115. Date of Electronic Publication: 2021 Oct 28.

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.

Autor: Mai QN; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Shenoy P; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Quach T; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Retamal JS; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Gondin AB; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Yeatman HR; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Aurelio L; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Conner JW; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Poole DP; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Canals M; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, The University of Nottingham Medical School, Nottingham, UK; Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, the Midlands, UK., Nowell CJ; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Graham B; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Davis TP; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Brisbane, Queensland, Australia., Briddon SJ; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, The University of Nottingham Medical School, Nottingham, UK; Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, the Midlands, UK., Hill SJ; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, The University of Nottingham Medical School, Nottingham, UK; Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, the Midlands, UK., Porter CJH; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Bunnett NW; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Department of Pharmacology and Therapeutics, The University of Melbourne, Parkville, Victoria, Australia; Department of Molecular Pathobiology, New York University College of Dentistry, New York, New York, USA. Electronic address: nwb2@nyu.edu., Halls ML; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Electronic address: michelle.halls@monash.edu., Veldhuis NA; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Drug Delivery, Disposition and Dynamics Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia; Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Electronic address: nicholas.veldhuis@monash.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100345. Date of Electronic Publication: 2021 Jan 28.

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability.

Autor: Peng S; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash University, Parkville, VIC, 3052, Australia., Grace MS; School of Medical Sciences and Health Innovations Research Institute, RMIT University, Bundoora, VIC, 3083, Australia.; Department of Physiology, School of Medicine Nursing and Health Sciences, Monash University, Clayton, VIC, 3800, Australia.; Baker IDI Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia., Gondin AB; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash University, Parkville, VIC, 3052, Australia., Retamal JS; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash University, Parkville, VIC, 3052, Australia., Dill L; School of Medical Sciences and Health Innovations Research Institute, RMIT University, Bundoora, VIC, 3083, Australia., Darby W; School of Medical Sciences and Health Innovations Research Institute, RMIT University, Bundoora, VIC, 3083, Australia., Bunnett NW; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash University, Parkville, VIC, 3052, Australia.; Department of Molecular Pathobiology, New York University, New York, NY, 10010, USA., Abogadie FC; School of Medical Sciences and Health Innovations Research Institute, RMIT University, Bundoora, VIC, 3083, Australia., Carbone SE; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia.; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash University, Parkville, VIC, 3052, Australia., Tigani T; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia., Davis TP; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash University, Parkville, VIC, 3052, Australia., Poole DP; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia. Daniel.Poole@monash.edu.; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash University, Parkville, VIC, 3052, Australia. Daniel.Poole@monash.edu.; Department of Anatomy & Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia. Daniel.Poole@monash.edu., Veldhuis NA; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Parkville, VIC, 3052, Australia. Nicholas.Veldhuis@monash.edu.; ARC Centre of Excellence in Convergent Bio-Nano Science & Technology, Monash University, Parkville, VIC, 3052, Australia. Nicholas.Veldhuis@monash.edu., McIntyre P; School of Medical Sciences and Health Innovations Research Institute, RMIT University, Bundoora, VIC, 3083, Australia.; The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, 3010, Australia.

Publikováno v: Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2020 Aug; Vol. 100 (8), pp. 1057-1067. Date of Electronic Publication: 2020 Apr 27.

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks.

Autor: Civciristov S; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia., Huang C; Monash Proteomics and Metabolomics Facility, Monash University, Clayton 3800, Victoria, Australia.; Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia., Liu B; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia., Marquez EA; Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia., Gondin AB; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia., Schittenhelm RB; Monash Proteomics and Metabolomics Facility, Monash University, Clayton 3800, Victoria, Australia.; Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia., Ellisdon AM; Monash Biomedicine Discovery Institute, Monash University, Clayton 3800, Victoria, Australia., Canals M; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia., Halls ML; Drug Discovery Biology Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Victoria, Australia michelle.halls@monash.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Nov 01; Vol. 294 (44), pp. 16198-16213. Date of Electronic Publication: 2019 Sep 12.