Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Goncalo Barreto"'
Autor:
Simone Ponta, Angela Bonato, Philipp Neidenbach, Valentino F. Bruhin, Alexis Laurent, Lee Ann Applegate, Marcy Zenobi-Wong, Goncalo Barreto
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-18 (2024)
Abstract Background CRISPR-Cas9-based genome engineering represents a powerful therapeutic tool for cartilage tissue engineering and for understanding molecular pathways driving cartilage diseases. However, primary chondrocytes are difficult to trans
Externí odkaz:
https://doaj.org/article/69a4ce8547824a6bb48b053444077404
Toll-like receptors and their soluble forms differ in the knee and thumb basal osteoarthritic joints
Publikováno v:
Acta Orthopaedica, Vol 88, Iss 3, Pp 326-333 (2017)
Background and purpose — Although the pathogenesis of osteoarthritis (OA) is not well understood, chondrocyte-mediated inflammatory responses (triggered by the activation of innate immune receptors by damage-associated molecules) are thought to be
Externí odkaz:
https://doaj.org/article/8cd2c7b6ee2e4c3685cc19b7dc26fbdf
Publikováno v:
Biology, Vol 9, Iss 4, p 65 (2020)
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In particular, chondrocyte-mediated inflammatory responses triggered by th
Externí odkaz:
https://doaj.org/article/bc8994a8679e4ba39135377969fca3a1
Autor:
Sandra López Cerdá, Flavia Fontana, Shiqi Wang, Alexandra Correia, Giuseppina Molinaro, Rubén Pareja Tello, Jouni Hirvonen, Christian Celia, Goncalo Barreto, Hélder A. Santos
Publikováno v:
Advanced Therapeutics. Wiley
Macrophages play a key role in the development of many diseases, like tissue injury, cancer and autoimmune diseases. So far, single-drug loaded nanoparticles have been developed to target macrophages. Nevertheless, macrophage dysregulation can induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9327520ad0054069b6e8b8ab1f33a168
https://research.rug.nl/en/publications/c94fdee6-24dd-4653-93ba-6026a63c0353
https://research.rug.nl/en/publications/c94fdee6-24dd-4653-93ba-6026a63c0353
Autor:
Angela Bonato, Philipp Fisch, Simone Ponta, David Fercher, Mikko Manninen, Daniel Weber, Kari K. Eklund, Goncalo Barreto, Marcy Zenobi‐Wong
Publikováno v:
Advanced Healthcare Materials, 12 (17)
Articular cartilage defects caused by traumatic injury rarely heal spontaneously and predispose into post-traumatic osteoarthritis. In the current autologous cell-based treatments the regenerative process is often hampered by the poor regenerative ca
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1142
Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is increasingly being used in analysis of biological samples. For example, it has been applied to distinguish healthy and osteoarthritic human cartilage. This chapter discusses ToF-SIMS princi
Autor:
Emanuele Perra, Eetu Lampsijärvi, Gonçalo Barreto, Muhammad Arif, Tuomas Puranen, Edward Hæggström, Kenneth P. H. Pritzker, Heikki J. Nieminen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics
Externí odkaz:
https://doaj.org/article/6ac85d15a7c24e85b23285311eb942ee
Autor:
Kaisa Hiippala, Gonçalo Barreto, Claudia Burrello, Angelica Diaz-Basabe, Maiju Suutarinen, Veera Kainulainen, Jolene R. Bowers, Darrin Lemmer, David M. Engelthaler, Kari K. Eklund, Federica Facciotti, Reetta Satokari
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Odoribacter splanchnicus, belonging to the order Bacteroidales, is a common, short-chain fatty acid producing member of the human intestinal microbiota. A decreased abundance of Odoribacter has been linked to different microbiota-associated diseases,
Externí odkaz:
https://doaj.org/article/5c6020f2dc13458a89479ec0a8d4862a
Autor:
Heikki J. Nieminen, Gonçalo Barreto, Mikko A. Finnilä, Alejandro García-Pérez, Ari Salmi, Sanjeev Ranjan, Kari K. Eklund, Kenneth P. H. Pritzker, Simo Saarakkala, Edward Hæggström
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Research is ongoing to develop drug therapies to manage osteoarthritis (OA) and articular cartilage (AC) injuries. However, means to deliver drug to localized AC lesions are highly limited and not clinically available. This study investigate
Externí odkaz:
https://doaj.org/article/4c04c73ebf2b43d4b65dd64e478ad414
Toll-like receptors and their soluble forms differ in the knee and thumb basal osteoarthritic joints
Background and purpose — Although the pathogenesis of osteoarthritis (OA) is not well understood, chondrocyte-mediated inflammatory responses (triggered by the activation of innate immune receptors by damage-associated molecules) are thought to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::131a8c744652cf433df55b47bf71ef96