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pro vyhledávání: '"Gonca Çetin"'
Autor:
Zeinab Waad Sadiq, Annamaria Brioli, Ruba Al-Abdulla, Gonca Çetin, Jacqueline Schütt, Hugo Murua Escobar, Elke Krüger, Frédéric Ebstein
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionProteasome inhibition is first line therapy in multiple myeloma (MM). The immunological potential of cell death triggered by defects of the ubiquitin-proteasome system (UPS) and subsequent perturbations of protein homeostasis is, however,
Externí odkaz:
https://doaj.org/article/44ee289e92e843e7a537f94d8279f0b3
Autor:
Gonca Çetin, Maja Studencka-Turski, Simone Venz, Eileen Schormann, Heike Junker, Elke Hammer, Uwe Völker, Frédéric Ebstein, Elke Krüger
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Microglia are the resident immune cells of the central nervous system (CNS) and play a major role in the regulation of brain homeostasis. To maintain their cellular protein homeostasis, microglia express standard proteasomes and immunoproteasomes (IP
Externí odkaz:
https://doaj.org/article/26329448f151440bac168b388391a784
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Proteostasis is critical for cells to maintain the balance between protein synthesis, quality control, and degradation. This is particularly important for myeloid cells of the central nervous system as their immunological function relies on proper in
Externí odkaz:
https://doaj.org/article/4c5fcced0f204de2aac2844ffe0bb77f
Publikováno v:
Biomolecules, Vol 11, Iss 1, p 60 (2021)
The ubiquitin–proteasome system (UPS) is the major intracellular and non-lysosomal protein degradation system. Thanks to its unique capacity of eliminating old, damaged, misfolded, and/or regulatory proteins in a highly specific manner, the UPS is
Externí odkaz:
https://doaj.org/article/916c8a143a9e4f588071c03c857e39ef