Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease

Autor: Muwanigwa, Mudiwa N., Modamio-Chamarro, Jennifer, Antony, Paul M.A., Gomez-Giro, Gemma, Krüger, Rejko, Bolognin, Silvia, Schwamborn, Jens C.

Publikováno v: In Molecular and Cellular Neuroscience March 2024 128

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Changes in Synaptic Proteins Precede Neurodegeneration Markers in Preclinical Alzheimer's Disease Cerebrospinal Fluid

Autor: Lleó, Alberto ^{‡, §, §§§, ¶¶¶}, Núñez-Llaves, Raúl ^{§, ¶, ¶¶¶}, Alcolea, Daniel ^{‡, §}, Chiva, Cristina ^{‖, **}, Balateu-Paños, Daniel ^¶, Colom-Cadena, Martí ^{§, ¶}, Gomez-Giro, Gemma ^¶, Muñoz, Laia ^{§, ¶}, Querol-Vilaseca, Marta ^{§, ¶}, Pegueroles, Jordi ^{§, ¶}, Rami, Lorena ^‡‡, Lladó, Albert ^‡‡, Molinuevo, José L. ^‡‡, Tainta, Mikel ^{§§, ¶¶}, Clarimón, Jordi ^{§, ¶}, Spires-Jones, Tara ^‖‖, Blesa, Rafael ^{‡, §}, Fortea, Juan ^{‡, §}, Martínez-Lage, Pablo ^§§, Sánchez-Valle, Raquel ^‡‡, Sabidó, Eduard ^{‖, **}, Bayés, Àlex ^{***, ‡‡‡}, Belbin, Olivia ^{§, ¶, ‖‖‖}

Publikováno v: In Molecular & Cellular Proteomics March 2019 18(3):546-560

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Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis.

Autor: Gomez-Giro, Gemma^1,2 (AUTHOR), Arias-Fuenzalida, Jonathan¹ (AUTHOR), Jarazo, Javier¹ (AUTHOR), Zeuschner, Dagmar³ (AUTHOR), Ali, Muhammad^4,5 (AUTHOR), Possemis, Nina¹ (AUTHOR), Bolognin, Silvia¹ (AUTHOR), Halder, Rashi⁶ (AUTHOR), Jäger, Christian⁷ (AUTHOR), Kuper, Willemijn F. E.⁸ (AUTHOR), van Hasselt, Peter M.⁸ (AUTHOR), Zaehres, Holm^2,9 (AUTHOR), del Sol, Antonio^4,10,11 (AUTHOR), van der Putten, Herman¹² (AUTHOR), Schöler, Hans R.² (AUTHOR), Schwamborn, Jens C.¹ (AUTHOR) jens.schwamborn@uni.lu

Publikováno v: Acta Neuropathologica Communications. 12/30/2019, Vol. 7 Issue 1, p1-19. 19p.