Substitution of the transmembrane domain of Vpu in simian–human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques

Autor: Hout, David R.¹, Gomez, Melissa L.¹, Pacyniak, Erik¹, Gomez, Lisa M.¹, Fegley, Barbara¹, Mulcahy, Ellyn R.¹, Hill, M. Sarah¹, Culley, Nathan², Pinson, David M.³, Nothnick, Warren⁴, Powers, Michael F.⁵, Wong, Scott W.⁵, Stephens, Edward B.¹ estephen@kumc.edu

Publikováno v: Virology. Jan2006, Vol. 344 Issue 2, p541-559. 19p.

Fusion of the upstream vpu sequences to the env of simian human immunodeficiency virus (SHIVKU-1bMC33) results in the synthesis of two envelope precursor proteins, increased numbers of virus particles associated with the cell surface and is pathogenic for pig-tailed macaques

Autor: Hout, David R.¹, Gomez, Melissa L.¹, Pacyniak, Erik¹, Mulcahy, Ellyn R.¹, Gomez, Lisa M.¹, Jackson, Mollie¹, Flick, Melissa¹, Fegley, Barbara, McCormick, Coleen², Wisdom, Billie J.³, Culley, Nathan⁴, Pinson, David M.⁵, Powers, Michael⁶, Wong, Scott W.⁶, Stephens, Edward B.¹ estephen@kumc.edu

Publikováno v: Virology. May2004, Vol. 323 Issue 1, p91-107. 17p.

Vpu: A Multifunctional Protein that Enhances the Pathogenesis of Human Immunodeficiency Virus Type 1

Autor: Hout, David R., Mulcahy, Ellyn R., Pacyniak, Erik, Gomez, Lisa M., Gomez, Melissa L., Stephens, Edward B.

Publikováno v: Current HIV Research; July 01, 2004, Vol. 2 Issue: 3 p255-270, 16p

Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques.

Autor: Hout DR; Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA., Gomez ML, Pacyniak E, Gomez LM, Fegley B, Mulcahy ER, Hill MS, Culley N, Pinson DM, Nothnick W, Powers MF, Wong SW, Stephens EB

Publikováno v: Virology [Virology] 2006 Jan 20; Vol. 344 (2), pp. 541-59. Date of Electronic Publication: 2005 Sep 30.

Vpu-mediated CD4 down-regulation and degradation is conserved among highly divergent SIV(cpz) strains.

Autor: Gomez LM; Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA., Pacyniak E, Flick M, Hout DR, Gomez ML, Nerrienet E, Ayouba A, Santiago ML, Hahn BH, Stephens EB

Publikováno v: Virology [Virology] 2005 Apr 25; Vol. 335 (1), pp. 46-60.