Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Golnar, Kolahgar"'
Publikováno v:
eLife, Vol 11 (2022)
Mechanisms communicating changes in tissue stiffness and size are particularly relevant in the intestine because it is subject to constant mechanical stresses caused by peristalsis of its variable content. Using the Drosophila intestinal epithelium,
Externí odkaz:
https://doaj.org/article/53b73869e8944cef9a9ff4459b9df2f6
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Cell competition causes the removal of less fit cells (‘losers’) but why some gene mutations turn cells into losers is unclear. Here, the authors show that Drosophila wing disc cells carrying some loser mutations activate Nrf2 and JNK signalling,
Externí odkaz:
https://doaj.org/article/40e708fdafc0405db4f51bc1e5a3c199
Publikováno v:
eLife. 11
Mechanisms communicating changes in tissue stiffness and size are particularly relevant in the intestine because it is subject to constant mechanical stresses caused by peristalsis of its variable content. Using theMechanical changes in the environme
Publikováno v:
Current Biology
Summary Tumor-host interactions play an increasingly recognized role in modulating tumor growth. Thus, understanding the nature and impact of this complex bidirectional communication is key to identifying successful anti-cancer strategies. It has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::14111338fbe07398f917dc4d28b4584d
https://www.repository.cam.ac.uk/handle/1810/253138
https://www.repository.cam.ac.uk/handle/1810/253138
Publikováno v:
Developmental Cell
Summary Wnt signaling is a key regulator of development that is often associated with cancer. Wingless, a Drosophila Wnt homolog, has been reported to be a survival factor in wing imaginal discs. However, we found that prospective wing cells survive
Publikováno v:
Development. 138:3021-3031
Epithelial homeostasis and the avoidance of diseases such as cancer require the elimination of defective cells by apoptosis. Here, we investigate how loss of apical determinants triggers apoptosis in the embryonic epidermis of Drosophila. Transcripti
Publikováno v:
Journal of Cellular Biochemistry. 95:763-768
The OZF (ZNF146) protein is a 33 kDa Kruppel protein, composed solely of 10 zinc finger motifs. It is overexpressed in the majority of pancreatic cancers and in more than 80% of colorectal cancers. We found an interaction between OZF and the telomeri
Publikováno v:
Trends in cell biology. 23(4)
Within tissues, cells sense differences in fitness levels and this can lead to fitter cells eliminating less fit, albeit viable, cells via competitive cell interactions. The involvement of several cancer-related genes in this phenomenon has drawn att
Autor:
Pierre-Luc Bardet, Irene Miguel-Aliaga, Jean-Paul Vincent, Golnar Kolahgar, Pascal Meier, James Briscoe, Anita Mynett
There is a growing interest in the mechanisms that control the apoptosis cascade during development and adult life. To investigate the regulatory events that trigger apoptosis in whole tissues, we have devised a genetically encoded caspase sensor tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1cf5e6740137de36f88a9a21a428a6
https://europepmc.org/articles/PMC2544551/
https://europepmc.org/articles/PMC2544551/