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A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis .

Autor: Pepi MJ; Graduate Program in Chemistry, Brandeis University, Waltham 02453, Massachusetts, United States., Chacko S; Department of Biology, Brandeis University, Waltham 02453, Massachusetts, United States., Marqus GM; Graduate Program in Chemistry, Brandeis University, Waltham 02453, Massachusetts, United States., Singh V; Drug Discovery and Development Centre (H3D), and South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa., Wang Z; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York 10065, New York, United States., Planck K; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York 10065, New York, United States., Cullinane RT; Department of Biology, Brandeis University, Waltham 02453, Massachusetts, United States., Meka PN; Department of Biology, Brandeis University, Waltham 02453, Massachusetts, United States., Gollapalli DR; Department of Biology, Brandeis University, Waltham 02453, Massachusetts, United States., Ioerger TR; Department of Computer Science and Engineering, Texas A&M University, College Station 77843, Texas, United States., Rhee KY; Division of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York 10065, New York, United States., Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston 77204, Texas, United States., Boshoff HIM; Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda 20892, Maryland, United States., Hedstrom L; Department of Biology, Brandeis University, Waltham 02453, Massachusetts, United States.; Department of Chemistry, Brandeis University, Waltham 02453, Massachusetts, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2022 Feb 11; Vol. 8 (2), pp. 330-342. Date of Electronic Publication: 2022 Jan 11.

The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections.

Autor: Modi G; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States., Marqus GM; Graduate Program in Chemistry, Brandeis University, Waltham Massachusetts 02453, United States., Vippila MR; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health Building 2, 4849 Calhoun Rd., Houston, Texas 77204, United States., Gollapalli DR; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States., Kim Y; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States.; The Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States., Manna AC; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, United States., Chacko S; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States., Maltseva N; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States.; The Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States., Wang X; Graduate Program in Chemistry, Brandeis University, Waltham Massachusetts 02453, United States., Cullinane RT; Department of Biochemistry, Brandeis University, Massachusetts 02453, United States., Zhang Y; Department of Biochemistry, Brandeis University, Massachusetts 02453, United States., Kotler JLM; Graduate Program in Biochemistry and Biophysics, Brandeis University, Waltham, Massachusetts 02453, United States., Kuzmic P; BioKin Ltd., Watertown, Massachusetts 02472, United States., Zhang M; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States., Lawson AP; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States., Joachimiak A; Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States.; The Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60367, United States., Cheung A; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, United States., Snider BB; Department of Chemistry, Brandeis University, Waltham, Massachusetts 02453, United States., Rothstein DM; David Rothstein Consulting, LLC, Lexington, Massachusetts 02421, United States., Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health Building 2, 4849 Calhoun Rd., Houston, Texas 77204, United States., Hedstrom L; Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States.; Department of Chemistry, Brandeis University, Waltham, Massachusetts 02453, United States.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2021 Nov 12; Vol. 7 (11), pp. 3062-3076. Date of Electronic Publication: 2021 Sep 30.