Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Golgi Apparatus/metabolism"'
Publikováno v:
Nature Communications. 13(1)
The protein kinase mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth and proliferation, supporting anabolic reactions and inhibiting catabolic pathways like autophagy. Its hyperactivation is a frequent event in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::c7015ff21183a55e9e73de884b7c95cd
https://doi.org/10.1038/s41467-022-32487-7
https://doi.org/10.1038/s41467-022-32487-7
Publikováno v:
Nature Communications. 13(1)
mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___00893::610fd571f5d2bc14e84fd609908b6f7a
https://hdl.handle.net/11370/c9d26e20-1728-4251-95ab-a03c61c26cca
https://hdl.handle.net/11370/c9d26e20-1728-4251-95ab-a03c61c26cca
Publikováno v:
Nature Communications. 13(1)
mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dris___01423::a8983aee7e37f8f24e383ed9f44283a7
https://research.rug.nl/en/publications/c9d26e20-1728-4251-95ab-a03c61c26cca
https://research.rug.nl/en/publications/c9d26e20-1728-4251-95ab-a03c61c26cca
Autor:
Kaeser-Pebernard, Stephanie, Vionnet, Christine, Mari, Muriel, Sankar, Devanarayanan Siva, Hu, Zehan, Roubaty, Carole, Martinez-Martinez, Esther, Zhao, Huiyuan, Spuch-Calvar, Miguel, Petri-Fink, Alke, Rainer, Gregor, Steinberg, Florian, Reggiori, Fulvio, Dengjel, Joern
Publikováno v:
Kaeser-Pebernard, S, Vionnet, C, Mari, M, Sankar, D S, Hu, Z, Roubaty, C, Martínez-Martínez, E, Zhao, H, Spuch-Calvar, M, Petri-Fink, A, Rainer, G, Steinberg, F, Reggiori, F & Dengjel, J 2022, ' mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1 ', Nature Communications, vol. 13, no. 1, 4685 . https://doi.org/10.1038/s41467-022-32487-7
Nature Communications, 13(1). Nature Publishing Group
Nature Communications, 13(1):4685. Nature Publishing Group
Nature Communications, 13(1). Nature Publishing Group
Nature Communications, 13(1):4685. Nature Publishing Group
mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0b6a00518154df4ad35bfaf4aade0ea4
https://pure.au.dk/portal/da/publications/mtorc1-controls-golgi-architecture-and-vesicle-secretion-by-phosphorylation-of-scyl1(32310649-10bb-427b-934c-d6c8be6b1464).html
https://pure.au.dk/portal/da/publications/mtorc1-controls-golgi-architecture-and-vesicle-secretion-by-phosphorylation-of-scyl1(32310649-10bb-427b-934c-d6c8be6b1464).html
Autor:
van Leeuwen, Wessel, Nguyen, Dan T M, Grond, Rianne, Veenendaal, Tineke, Rabouille, Catherine, Farías, Ginny G, Celbiologie, Sub Cell Biology
Publikováno v:
Journal of Cell Science, 135(23). Company of Biologists Ltd
Journal of Cell Science, 135(23). COMPANY OF BIOLOGISTS LTD
Journal of Cell Science, 135(23). COMPANY OF BIOLOGISTS LTD
Phase separation of ER-exit-sites (ERES) components into membraneless compartments, the Sec bodies, occurs in Drosophila cells upon specific cellular stressors, i.e., salt stress and amino acid starvation, and their formation is linked to the inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6caf48ce216db945bcb3abd5f66fbfd
https://pubmed.ncbi.nlm.nih.gov/36325988
https://pubmed.ncbi.nlm.nih.gov/36325988
Autor:
Wim Annaert, Katleen Dillen, Randy Schekman, Ragna Sannerud, Bertrand Kleizen, Rosanne Wouters, David Demedts, Christine Michiels, Abril Escamilla Ayala, Wendy Vermeire
Publikováno v:
Journal of Cell Biology, 220(9), 1. Rockefeller University Press
γ-Secretase affects many physiological processes through targeting >100 substrates; malfunctioning links γ-secretase to cancer and Alzheimer's disease. The spatiotemporal regulation of its stoichiometric assembly remains unresolved. Fractionation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d9039d96590f096bfacb0662aeabdb
https://doi.org/10.1083/jcb.201911104
https://doi.org/10.1083/jcb.201911104
Autor:
Wouters, Rosanne, Michiels, Christine, Sannerud, Ragna, Kleizen, Bertrand, Dillen, Katleen, Vermeire, Wendy, Ayala, Abril, Demedts, David, Annaert, Wim, SCHEKMAN, Randy W
Publikováno v:
The Journal of Cell Biology, vol 220, iss 9
γ-Secretase affects many physiological processes through targeting >100 substrates; malfunctioning links γ-secretase to cancer and Alzheimers disease. The spatiotemporal regulation of its stoichiometric assembly remains unresolved. Fractionation, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f2ae0199a715d64c89f2a0ccb4aace5c
https://dspace.library.uu.nl/handle/1874/414000
https://dspace.library.uu.nl/handle/1874/414000
Autor:
Peter W. Schiller, Miriam Carolin Stoeber, Toon Laeremans, Mark von Zastrow, Damien Jullié, Jan Steyaert, Aashish Manglik, Braden T. Lobingier
Publikováno v:
Neuron, Vol. 98, No 5 (2018) pp. 963-976.e5
Neuron, vol 98, iss 5
Neuron, vol 98, iss 5
Opioid receptors (ORs) precisely modulate behavior when activated by native peptide ligands but distort behaviors to produce pathology when activated by non-peptide drugs. A fundamental question is how drugs differ from peptides in their actions on t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311df52235dce874c11fd418aaca5dae
https://archive-ouverte.unige.ch/unige:123106
https://archive-ouverte.unige.ch/unige:123106
Autor:
Ariane Dimitrov, Raja Bonifay, Cécile Bougeret, Hugo Bousquet, Gaëlle Bressanelli, Arnaud Echard, Vincent Fraisier, Bruno Goud, Olena Pylypenko, Sabine Bardin, Catherine Guillou, Anne Houdusse, Stéphanie Miserey-Lenkei
Publikováno v:
Nature Communications
Nature Communications, 2017, 8 (1), pp.1254. ⟨10.1038/s41467-017-01266-0⟩
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Nature Publishing Group, 2017, 8 (1), pp.1254. ⟨10.1038/s41467-017-01266-0⟩
'Nature Communications ', vol: 8, pages: 1254-1-1254-13 (2017)
Nature Communications, 2017, 8 (1), pp.1254. ⟨10.1038/s41467-017-01266-0⟩
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Nature Publishing Group, 2017, 8 (1), pp.1254. ⟨10.1038/s41467-017-01266-0⟩
'Nature Communications ', vol: 8, pages: 1254-1-1254-13 (2017)
The actin and microtubule cytoskeletons play important roles in Golgi structure and function, but how they are connected remain poorly known. In this study, we investigated whether RAB6 GTPase, a Golgi-associated RAB involved in the regulation of sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94563cceacba255a8dcff764307474b1
https://doi.org/10.1038/s41467-017-01266-0
https://doi.org/10.1038/s41467-017-01266-0
Autor:
Alexey Koval, Chen Lin, Anne-marie Lüchtenborg, Vladimir L. Katanaev, Oleksii Bilousov, Gonzalo P. Solis
Publikováno v:
Cell, Vol. 170, No 5 (2017) pp. 939-955.e24
Cell, vol. 170, no. 5, pp. 939-955.e24
Cell, vol. 170, no. 5, pp. 939-955.e24
To form protrusions like neurites, cells must coordinate their induction and growth. The first requires cytoskeletal rearrangements at the plasma membrane (PM), the second requires directed material delivery from cell's insides. We find that the Gαo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e20cacad29e4dc2a9f9594349cef9572
https://archive-ouverte.unige.ch/unige:112473
https://archive-ouverte.unige.ch/unige:112473