Advancements in risk stratification and management strategies in primary cardiovascular prevention

Autor: Barkas, Fotios, Sener, Yusuf Ziya, Golforoush, Pelin Arabacilar, Kheirkhah, Azin, Rodriguez-Sanchez, Elena, Novak, Jan, Apellaniz-Ruiz, Maria, Akyea, Ralph Kwame, Bianconi, Vanessa, Ceasovschih, Alexandr, Chee, Ying Jie, Cherska, Mariia, Chora, Joana Rita, D'Oria, Mario, Demikhova, Nadiia, Kocyigit Burunkaya, Duygu, Rimbert, Antoine, Macchi, Chiara, Rathod, Krishnaraj, Roth, Lynn, Sukhorukov, Vasily, Stoica, Svetlana, Scicali, Roberto, Storozhenko, Tatyana, Uzokov, Jamol, Lupo, Maria Giovanna, van der Vorst, Emiel P.C., Porsch, Florentina

Publikováno v: In Atherosclerosis August 2024 395

The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules

Autor: De Nicola, Gian F., Bassi, Rekha, Nichols, Charlie, Fernandez-Caggiano, Mariana, Golforoush, Pelin Arabacilar, Thapa, Dibesh, Anderson, Rhys, Martin, Eva Denise, Verma, Sharwari, Kleinjung, Jens, Laing, Adam, Hutchinson, Jonathan P., Eaton, Philip, Clark, James, Marber, Michael S.

Publikováno v: De Nicola, G F, Bassi, R, Nichols, C, Fernandez-Caggiano, M, Golforoush, P A, Thapa, D, Anderson, R, Martin, E D, Verma, S, Kleinjung, J, Laing, A, Hutchinson, J P, Eaton, P, Clark, J & Marber, M S 2018, ' The TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules ', JCI Insight, vol. 3, no. 16, pp. 1-17 . https://doi.org/10.1172/jci.insight.121144

Inhibiting MAPK14 (p38α) diminishes cardiac damage in myocardial ischemia. During myocardial ischemia, p38α interacts with TAB1, a scaffold protein, which promotes p38α autoactivation; active p38α (pp38α) then transphosphorylates TAB1. Previousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2761::78b4a6afe514d91568f3911d17e22754
https://kclpure.kcl.ac.uk/ws/files/101329399/The_TAB1_p38_complex_DE_NICOLA_Accepted5July2018_GOLD_VoR_CC_BY_.pdf

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