Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Golec, Julian M. C."'
Autor:
Somhairle Maccormick, Steven Durrant, Anisa Nizarali Virani, Christopher John Davis, Steve Young, Golec Julian M C, Storck Pierre Henri, Philip Michael Reaper, David Kay, John Pollard, Michael O'donnell, Heather Twin, Jean-Damien Charrier, Peter Littlewood, Matthew R. Griffiths, Joanne Pinder, Ronald Knegtel
Publikováno v:
Journal of medicinal chemistry. 62(11)
The DNA damage response (DDR) is a DNA damage surveillance and repair mechanism that can limit the effectiveness of radiotherapy and DNA-damaging chemotherapy, commonly used treatment modalities in cancer. Two related kinases, ataxia telangiectasia m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::236bb1d7274297437c1461393876f89b
https://pubmed.ncbi.nlm.nih.gov/31074988
https://pubmed.ncbi.nlm.nih.gov/31074988
Autor:
Peter A. Charlton, Valerie Legris, John Pollard, Philip Michael Reaper, Jay A. Bertrand, Golec Julian M C, Sarah Vial, Michael K. Swan, Rebecca Bordas, Adam Tanner
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 70:1465-1475
Bloom's syndrome is an autosomal recessive genome-instability disorder associated with a predisposition to cancer, premature aging and developmental abnormalities. It is caused by mutations that inactivate the DNA helicase activity of the BLM protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05d2750cde1a1c6b8f120a39accd0d7a
https://doi.org/10.1107/s139900471400501x
https://doi.org/10.1107/s139900471400501x
Autor:
Paul S.H. Wang, Michael O'donnell, Alistair Rutherford, John Pollard, Jean-Damien Charrier, Somhairle Maccormick, Ronald Knegtel, Philip Michael Reaper, David Kay, Joanne Pinder, Steven Durrant, Michael Mortimore, Stephen Clinton Young, Golec Julian M C
Publikováno v:
Journal of Medicinal Chemistry. 54:2320-2330
DNA-damaging agents are among the most frequently used anticancer drugs. However, they provide only modest benefit in most cancers. This may be attributed to a genome maintenance network, the DNA damage response (DDR), that recognizes and repairs dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58e4f118a9c832e643b8ec56a190cfd
https://doi.org/10.1021/jm101488z
https://doi.org/10.1021/jm101488z
Autor:
John Pollard, Francesca Mazzei, Chau Mak, Damien Fraysse, Sanjay Patel, Sharn Ramaya, David Bebbington, John Studley, Joanne Pinder, Ronald Knegtel, Daniel Robinson, Andrew Miller, Francoise Pierard, Michael O'donnell, Alistair Rutherford, Jean-Damien Charrier, David Kay, Michael Mortimore, Simon Everitt, Hayley Binch, Golec Julian M C, James Westcott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3586-3592
The identification of a novel series of Aurora kinase inhibitors and exploitation of their SAR is described. Replacement of the initial quinazoline core with a pyrimidine scaffold and modification of substituents led to a series of very potent inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0925b30e50e9b61648460b5b023cd8ac
https://doi.org/10.1016/j.bmcl.2009.04.136
https://doi.org/10.1016/j.bmcl.2009.04.136
Autor:
Crystal Tolman, Philip Michael Reaper, Dave Newsome, Yong Gu, Brian Hare, Peter A. Charlton, Jean-Damien Charrier, Sean Milton, Mark Wood, Mac Johnson, Diane M. Boucher, Yuxin Wang, Brenda K. Eustace, Howard Li, Golec Julian M C, Darin Takemoto, Amy B. Hall, Cheryl Murphy, John Pollard, Brinley Furey
Publikováno v:
Oncotarget
// Amy B. Hall 1,* , Dave Newsome 1,* , Yuxin Wang 1,* , Diane M. Boucher 1 , Brenda Eustace 1 , Yong Gu 1 , Brian Hare 1 , Mac A. Johnson 1 , Howard Li 1 , Sean Milton 1 , Cheryl E. Murphy 1 , Darin Takemoto 1 , Crystal Tolman 1 , Mark Wood 1 , Pete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a9e0ccaea1da6daec49326ca02e741
https://pubmed.ncbi.nlm.nih.gov/25010037
https://pubmed.ncbi.nlm.nih.gov/25010037
Autor:
Teresa Brooks, Richard Faint, Sukhjit Sohal, Adrian Folkes, Golec Julian M C, Peter Charlton, Michael Bryan Roe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2589-2592
We have synthesized and evaluated a series of diketopiperazine-based inhibitors of PAI-1. These studies resulted in the identification of 34 which inhibited PAI-1 in vitro with an IC 50 =0.2 μM. The synthesis and SAR of these compounds are described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::766e7b20a095c6f68d57e64459468757
https://doi.org/10.1016/s0960-894x(01)00508-x
https://doi.org/10.1016/s0960-894x(01)00508-x
Autor:
Stuart Donald Jones, Murdoch Robert, Mullican Michael D, Golec Julian M C, Yu-Ping Luong, David J. Livingston, Scott A. Raybuck, Guy W. Bemis, Murcko Mark A, David Kay, Wilson Keith P
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2181-2186
Pyridone derivatives, especially with 6-aryl substituents, have been shown to be useful P2-P3 peptidomimetic scaffolds for the design of potent inhibitors of ICE.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::414dc5a161182b8e487d4a6ff846f727
https://doi.org/10.1016/s0960-894x(97)00394-6
https://doi.org/10.1016/s0960-894x(97)00394-6
Autor:
Phillip L. Evans, Saroop S. Matharu, Scott A. Raybuck, David Kay, Yu-Ping Luong, Lauffer David J, Murcko Mark A, David J. Livingston, Mullican Michael D, Golec Julian M C, Roger John Gillespie, Geoffrey M. Porritt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2359-2364
The tetrapeptide aldehyde Ac-Tyr-Val-Ala-AspH ( 1 , L-709,049) has been reported to be a potent reversible inhibitor of Interleukin-1β Converting Enzyme (ICE). We have prepared a series of analogs of 1 , in order to explore the active sige of ICE. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab93ad698808a5cf3b6d4bee3e5c5c3d
https://doi.org/10.1016/0960-894x(94)85040-2
https://doi.org/10.1016/0960-894x(94)85040-2
Autor:
Stuart Donald Jones, Murdoch Robert, Golec Julian M C, Roger John Gillespie, Mark Batchelor, Hedgecock Charles John Robert
Publikováno v:
Tetrahedron. 50:809-826
The total synthesis of an analogue of FK506, in which the substituted cyclohexyl residue at C28 has been replaced by a phenyl group, is described. This synthesis demonstrates (i) the successful application of new methodology for the introduction of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcf2e783606572cdb490baaeaf2d7684
https://doi.org/10.1016/s0040-4020(01)80796-1
https://doi.org/10.1016/s0040-4020(01)80796-1
Autor:
Golec Julian M C, Stuart Donald Jones
Publikováno v:
Tetrahedron Letters. 34:8159-8162
The asymmetric synthesis of a fragment corresponding to the C 1 -C 8 region of the immunosuppressant dicodermolide is reported. A trihydroxylactone of defined absolute stereochemistry is also prepared. This compound is a potential reductive ozonolysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7ed616850c2f1a0fe625c0e26d0ed7c
https://doi.org/10.1016/s0040-4039(00)61479-x
https://doi.org/10.1016/s0040-4039(00)61479-x