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Genome engineering for estrogen receptor mutations reveals differential responses to anti-estrogens and new prognostic gene signatures for breast cancer.

Autor: Harrod A; Department of Surgery & Cancer, Imperial College London, London, W12 0NN, UK.; Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK., Lai CF; Department of Surgery & Cancer, Imperial College London, London, W12 0NN, UK., Goldsbrough I; Department of Surgery & Cancer, Imperial College London, London, W12 0NN, UK., Simmons GM; Department of Surgery & Cancer, Imperial College London, London, W12 0NN, UK., Oppermans N; Department of Surgery & Cancer, Imperial College London, London, W12 0NN, UK., Santos DB; Department of Surgery & Cancer, Imperial College London, London, W12 0NN, UK., Győrffy B; Semmelweis University Department of Bioinformatics, H-1094 Budapest, Hungary and TTK Cancer Biomarker Research Group, H-1117, Budapest, Hungary., Allsopp RC; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK., Toghill BJ; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK., Balachandran K; Department of Surgery & Cancer, Imperial College London, London, W12 0NN, UK., Lawson M; Early Oncology R&D, AstraZeneca, Biomedical Campus, 1 Francis Crick Ave, Cambridge, CB2 0AA, UK., Morrow CJ; Early Oncology R&D, AstraZeneca, Biomedical Campus, 1 Francis Crick Ave, Cambridge, CB2 0AA, UK., Surakala M; Early Oncology R&D, AstraZeneca, Biomedical Campus, 1 Francis Crick Ave, Cambridge, CB2 0AA, UK., Carnevalli LS; Early Oncology R&D, AstraZeneca, Biomedical Campus, 1 Francis Crick Ave, Cambridge, CB2 0AA, UK., Zhang P; Early Oncology R&D, AstraZeneca, Biomedical Campus, 1 Francis Crick Ave, Cambridge, CB2 0AA, UK., Guttery DS; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK., Shaw JA; Leicester Cancer Research Centre, Department of Genetics and Genome Biology, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, UK., Coombes RC; Department of Surgery & Cancer, Imperial College London, London, W12 0NN, UK., Buluwela L; Department of Surgery & Cancer, Imperial College London, London, W12 0NN, UK. l.buluwela@imperial.ac.uk., Ali S; Department of Surgery & Cancer, Imperial College London, London, W12 0NN, UK. simak.ali@imperial.ac.uk.

Publikováno v: Oncogene [Oncogene] 2022 Oct; Vol. 41 (44), pp. 4905-4915. Date of Electronic Publication: 2022 Oct 05.

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Ribociclib Induces Broad Chemotherapy Resistance and EGFR Dependency in ESR1 Wildtype and Mutant Breast Cancer.

Autor: Mayayo-Peralta I; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Faggion B; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Hoekman L; Proteomics Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Morris B; Division of Molecular Carcinogenesis and Robotics and Screening Centre, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands., Lieftink C; Division of Molecular Carcinogenesis and Robotics and Screening Centre, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands., Goldsbrough I; Department of Surgery & Cancer, Imperial College London, London SW7 2BX, UK., Buluwela L; Department of Surgery & Cancer, Imperial College London, London SW7 2BX, UK., Siefert JC; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Post H; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CS Utrecht, The Netherlands., Altelaar M; Proteomics Facility, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584 CS Utrecht, The Netherlands., Beijersbergen R; Division of Molecular Carcinogenesis and Robotics and Screening Centre, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands., Ali S; Department of Surgery & Cancer, Imperial College London, London SW7 2BX, UK., Zwart W; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.; Laboratory of Chemical Biology and Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, 5612 AZ Eindhoven, The Netherlands., Prekovic S; Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands.

Publikováno v: Cancers [Cancers (Basel)] 2021 Dec 16; Vol. 13 (24). Date of Electronic Publication: 2021 Dec 16.

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The Use of Next-Generation Sequencing in Personalized Medicine.

Autor: Popova L; Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, USA., Carabetta VJ; Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ, USA. carabetta@rowan.edu.

Publikováno v: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2025; Vol. 2866, pp. 287-315.

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