Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity

Autor: LaMonte, GM, Almaliti, J, Bibo-Verdugo, B, Keller, L, Zou, BY, Yang, J, Antonova-Koch, Y, Orjuela-Sanchez, P, Boyle, CA, Vigil, E, Wang, L, Goldgof, GM, Gerwick, L, O'Donoghue, AJ, Winzeler, EA, Gerwick, WH, Ottilie, S

Publikováno v: Journal of Medicinal Chemistry
LaMonte, GM; Almaliti, J; Bibo-Verdugo, B; Keller, L; Zou, BY; Yang, J; et al.(2017). Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity. JOURNAL OF MEDICINAL CHEMISTRY, 60(15), 6721-6732. doi: 10.1021/acs.jmedchem.7b00671. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0r57k1b0

Naturally derived chemical compounds are the foundation of much of our pharmacopeia, especially in antiproliferative and anti-infective drug classes. Here, we report that a naturally derived molecule called carmaphycin B is a potent inhibitor against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f8c707eab7509a6569f1586119dd0a99
http://europepmc.org/articles/PMC5554889

Novel computational methods on electronic health record yields new estimates of transfusion-associated circulatory overload in populations enriched with high-risk patients.

Autor: Wang M; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, California, USA.; Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.; Graduate Program in Pharmaceutical Sciences and Pharmacogenomics, University of California, San Francisco, San Francisco, California, USA., Goldgof GM; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, California, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Patel A; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, California, USA.; Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA., Whitaker B; Office of Biostatistics & Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland, USA., Belov A; Office of Biostatistics & Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland, USA., Chan B; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, California, USA., Phelps E; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, California, USA., Rubin B; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, California, USA.; Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA., Anderson S; Office of Biostatistics & Epidemiology, Center for Biologics Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland, USA., Butte AJ; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, California, USA.; Department of Pediatrics, University of California, San Francisco, San Francisco, California, USA.; Center for Data-driven Insights and Innovation, University of California Health, Oakland, USA.

Publikováno v: Transfusion [Transfusion] 2023 Jul; Vol. 63 (7), pp. 1298-1309. Date of Electronic Publication: 2023 May 29.

Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance.

Autor: Ottilie S; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Luth MR; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Hellemann E; Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, PA, 15260, USA., Goldgof GM; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Vigil E; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Kumar P; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Cheung AL; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Song M; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Godinez-Macias KP; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Carolino K; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Yang J; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Lopez G; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Abraham M; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Tarsio M; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, New York, NY, 13210, USA., LeBlanc E; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5G 1M1, Canada., Whitesell L; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5G 1M1, Canada., Schenken J; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Gunawan F; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Patel R; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Smith J; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA., Love MS; Calibr, a division of The Scripps Research Institutes, La Jolla, CA, 92037, USA., Williams RM; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA.; Aspen Neuroscience, San Diego, CA, 92121, USA., McNamara CW; Calibr, a division of The Scripps Research Institutes, La Jolla, CA, 92037, USA., Gerwick WH; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, La Jolla, CA, 92037, USA., Ideker T; Department of Medicine, University of California San Diego, La Jolla, CA, USA., Suzuki Y; Department of Synthetic Biology and Bioenergy, J. Craig Venter Institute, La Jolla, CA, 92037, USA., Wirth DF; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA, 02142, USA., Lukens AK; Infectious Disease and Microbiome Program, Broad Institute, Cambridge, MA, 02142, USA., Kane PM; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, New York, NY, 13210, USA., Cowen LE; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5G 1M1, Canada., Durrant JD; Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, PA, 15260, USA., Winzeler EA; Department of Pediatrics, University of California, San Diego, Gilman Dr, La Jolla, CA, 92093, USA. ewinzeler@health.ucsd.edu.

Publikováno v: Communications biology [Commun Biol] 2022 Feb 11; Vol. 5 (1), pp. 128. Date of Electronic Publication: 2022 Feb 11.

Magnitude and Kinetics of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Responses and Their Relationship to Disease Severity.

Autor: Lynch KL; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Whitman JD; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Lacanienta NP; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Beckerdite EW; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Kastner SA; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Shy BR; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Goldgof GM; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Levine AG; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Bapat SP; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Stramer SL; Scientific Affairs, American Red Cross, Gaithersberg, Maryland, USA., Esensten JH; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA., Hightower AW; Independent consultant, Bangkok, Thailand., Bern C; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA., Wu AHB; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Jan 27; Vol. 72 (2), pp. 301-308.

Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.

Autor: Whitman JD; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Hiatt J; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Mowery CT; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Shy BR; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Yu R; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Yamamoto TN; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Rathore U; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Goldgof GM; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Whitty C; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Woo JM; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Gallman AE; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, USA., Miller TE; Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Levine AG; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Nguyen DN; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA., Bapat SP; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Balcerek J; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Bylsma SA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA., Lyons AM; Department of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA., Li S; Department of Integrative Biology, University of California, Berkeley, Berkeley, CA, USA., Wong AW; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA., Gillis-Buck EM; Department of Surgery, University of California, San Francisco, San Francisco, CA, USA., Steinhart ZB; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Lee Y; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA., Apathy R; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Lipke MJ; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Smith JA; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Zheng T; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Department of Neurology, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Boothby IC; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA., Isaza E; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Program in Quantitative Biology, University of California, San Francisco, San Francisco, CA, USA., Chan J; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA., Acenas DD 2nd; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA., Lee J; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; School of Medicine, University of California, San Francisco, San Francisco, CA, USA., Macrae TA; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; School of Medicine, University of California, San Francisco, San Francisco, CA, USA., Kyaw TS; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA., Wu D; Medical Scientist Training Program, University of California, San Francisco, San Francisco, CA, USA.; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Ng DL; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.; Department of Pathology, University of California, San Francisco, San Francisco, CA, USA., Gu W; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., York VA; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Eskandarian HA; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Callaway PC; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Infectious Diseases and Immunity Graduate Group, University of California, Berkeley, Berkeley, CA, USA., Warrier L; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Moreno ME; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Levan J; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Torres L; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Farrington LA; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Loudermilk RP; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Koshal K; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Zorn KC; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA., Garcia-Beltran WF; Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Yang D; Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Astudillo MG; Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Bernstein BE; Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Gelfand JA; Division of Infectious Diseases, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Ryan ET; Division of Infectious Diseases, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Charles RC; Division of Infectious Diseases, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Iafrate AJ; Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Lennerz JK; Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA., Miller S; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Chiu CY; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA.; UCSF-Abbott Viral Diagnostics and Discovery Center, San Francisco, CA, USA., Stramer SL; Scientific Affairs, American Red Cross, Gaithersburg, MD, USA., Wilson MR; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA.; Weill Institute for Neurosciences, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA., Manglik A; Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA, USA.; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA., Ye CJ; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA.; Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Institute of Computational Health Sciences, University of California, San Francisco, San Francisco, CA, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA., Krogan NJ; J. David Gladstone Institutes, San Francisco, CA, USA.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA., Anderson MS; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA., Cyster JG; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA.; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, USA., Ernst JD; Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Wu AHB; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Lynch KL; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Bern C; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA. caryn.bern2@ucsf.edu., Hsu PD; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. pdhsu@berkeley.edu.; Department of Bioengineering, University of California, Berkeley, Berkeley, CA, USA. pdhsu@berkeley.edu.; Center for Computational Biology, University of California, Berkeley, Berkeley, CA, USA. pdhsu@berkeley.edu., Marson A; J. David Gladstone Institutes, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA. alexander.marson@ucsf.edu.; Diabetes Center, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Chan Zuckerberg Biohub, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.; Division of Rheumatology, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA. alexander.marson@ucsf.edu.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2020 Oct; Vol. 38 (10), pp. 1174-1183. Date of Electronic Publication: 2020 Aug 27.