Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial

Autor: Chen, RY, Via, LE, Dodd, LE, Walzl, G, Malherbe, ST, Loxton, AG, Dawson, R, Wilkinson, RJ, Thienemann, F, Tameris, M, Hatherill, M, Diacon, AH, Liu, X, Xing, J, Jin, X, Ma, Z, Pan, S, Zhang, G, Gao, Q, Jiang, Q, Zhu, H, Liang, L, Duan, H, Song, T, Alland, D, Tartakovsky, M, Rosenthal, A, Whalen, C, Duvenhage, M, Cai, Y, Goldfeder, LC, Arora, K, Smith, B, Winter, J, Barry Iii, CE, Predict TB Study Group

Background: By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months, maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have failed, with 4-month arms consistently having relapse rates of 15-20%. On

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf92b84578644929cf424244724f99ac

Radiological and functional evidence of the bronchial spread of tuberculosis: an observational analysis.

Autor: Chen RY; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa., Yu X; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Smith B; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Liu X; Henan Provincial Chest Hospital, Zhengzhou, Henan, China., Gao J; Sino-US Tuberculosis Collaborative Research Program, Zhengzhou, Henan, China., Diacon AH; Department of Medicine, Stellenbosch University, Cape Town, South Africa.; TASK Applied Science, Cape Town, South Africa., Dawson R; Division of Pulmonology, Department of Medicine, University of Cape Town Lung Institute, University of Cape Town, Cape Town, South Africa., Tameris M; South African Tuberculosis Vaccine Initiative, University of Cape Town, Cape Town, South Africa., Zhu H; Sino-US Tuberculosis Collaborative Research Program, Zhengzhou, Henan, China., Qu Y; Kaifeng City Institute of Tuberculosis Prevention and Control, Kaifeng, Henan, China., Zhang R; Xinxiang City Institute of Tuberculosis Prevention and Control, Xinxiang, Henan, China., Pan S; Zhongmu County Health and Epidemic Prevention Station, Zhongmu, Henan, China., Jin X; Xinmi City Institute of Tuberculosis Prevention and Control, Xinmi, Henan, China., Goldfeder LC; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Cai Y; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Arora K; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Wang J; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Vincent J; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA., Malherbe ST; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Thienemann F; Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Department of Internal Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland., Wilkinson RJ; Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa.; Francis Crick Institute, London, UK.; Department of Infectious Diseases, Imperial College London, London, UK., Walzl G; DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Barry CE 3rd; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Publikováno v: The Lancet. Microbe [Lancet Microbe] 2021 Oct; Vol. 2 (10), pp. e518-e526.

Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial.

Autor: Chen RY; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Via LE; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.; Wellcome Centre for Infectious Diseases Research in Africa,Institute of Infectious Disease and Molecular Medicine, University of Cape Town (UCT), Cape Town, South Africa., Dodd LE; Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Walzl G; South Africa Department of Science and Technology - National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Malherbe ST; South Africa Department of Science and Technology - National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Loxton AG; South Africa Department of Science and Technology - National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Dawson R; Division of Pulmonology, Department of Medicine, University Of Cape Town Lung Institute, University of Cape Town (UCT), Cape Town, South Africa., Wilkinson RJ; Wellcome Centre for Infectious Diseases Research in Africa,Institute of Infectious Disease and Molecular Medicine, University of Cape Town (UCT), Cape Town, South Africa.; Francis Crick Institute, London, NW1 2AT, UK.; Department of Medicine, Imperial College London, London, W2 1PG, UK., Thienemann F; Wellcome Centre for Infectious Diseases Research in Africa,Institute of Infectious Disease and Molecular Medicine, University of Cape Town (UCT), Cape Town, South Africa.; Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland., Tameris M; South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT), Cape Town, South Africa., Hatherill M; South African Tuberculosis Vaccine Initiative, University of Cape Town (UCT), Cape Town, South Africa., Diacon AH; TASK Applied Science and Stellenbosch University, Cape Town, South Africa., Liu X; Henan Provincial Chest Hospital, Zhengzhou, Henan, China., Xing J; Henan Provincial Institute of Tuberculosis and Prevention, Henan Center for Disease Control, Zhengzhou, Henan, China., Jin X; Xinmi City Institute of Tuberculosis Prevention and Control, Xinmi, Henan, China., Ma Z; Kaifeng City Institute of Tuberculosis Prevention and Control, Kaifeng, Henan, China., Pan S; Zhongmu County Health and Epidemic Prevention Station, Zhongmu, Henan, China., Zhang G; Henan Provincial Institute of Tuberculosis and Prevention, Henan Center for Disease Control, Zhengzhou, Henan, China., Gao Q; Fudan University, Shanghai, China., Jiang Q; Fudan University, Shanghai, China., Zhu H; Sino-US Tuberculosis Collaborative Research Program, Zhengzhou, Henan, China., Liang L; TASK Applied Science and Stellenbosch University, Cape Town, South Africa., Duan H; Beijing Chest Hospital, Beijing, China., Song T; Institute of Infectious Disease and Molecular Medicine, University of Cape Town (UCT), Cape Town, South Africa., Alland D; Division of Infectious Diseases, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA., Tartakovsky M; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Rosenthal A; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Whalen C; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Duvenhage M; Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Cai Y; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Goldfeder LC; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Arora K; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Smith B; South Africa Department of Science and Technology - National Research Foundation Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa., Winter J; Catalysis Foundation for Health, Emeryville, CA, USA., Barry Iii CE; Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.; Wellcome Centre for Infectious Diseases Research in Africa,Institute of Infectious Disease and Molecular Medicine, University of Cape Town (UCT), Cape Town, South Africa.

Publikováno v: Gates open research [Gates Open Res] 2017 Nov 06; Vol. 1, pp. 9. Date of Electronic Publication: 2017 Nov 06.

Linezolid Trough Concentrations Correlate with Mitochondrial Toxicity-Related Adverse Events in the Treatment of Chronic Extensively Drug-Resistant Tuberculosis.

Autor: Song T; International Tuberculosis Research Center, Changwon, Republic of Korea., Lee M; International Tuberculosis Research Center, Changwon, Republic of Korea., Jeon HS; International Tuberculosis Research Center, Changwon, Republic of Korea., Park Y; International Tuberculosis Research Center, Changwon, Republic of Korea., Dodd LE; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Dartois V; Public Health Research Institute, New Jersey Medical School, Rutgers, Newark, NJ, USA., Follman D; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Wang J; Clinical Research Directorate, Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Cai Y; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Goldfeder LC; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Olivier KN; Cardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Xie Y; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Via LE; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Rondebosch, Cape Town, 7701, Republic of South Africa., Cho SN; Department of Microbiology and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Republic of Korea., Barry CE 3rd; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA; Department of Clinical Laboratory Sciences, Faculty of Health Sciences, University of Cape Town, Rondebosch, Cape Town, 7701, Republic of South Africa., Chen RY; Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Publikováno v: EBioMedicine [EBioMedicine] 2015 Oct 09; Vol. 2 (11), pp. 1627-33. Date of Electronic Publication: 2015 Oct 09 (Print Publication: 2015).

Predictors of pulmonary tuberculosis treatment outcomes in South Korea: a prospective cohort study, 2005-2012.

Autor: Choi H, Lee M, Chen RY, Kim Y, Yoon S, Joh JS, Park SK, Dodd LE, Lee J, Song T, Cai Y, Goldfeder LC, Via LE, Carroll MW, Barry CE 3rd, Cho SN; International Tuberculosis Research Center, Changwon, Republic of Korea. raycho@yonsei.kr.

Publikováno v: BMC infectious diseases [BMC Infect Dis] 2014 Jul 02; Vol. 14, pp. 360. Date of Electronic Publication: 2014 Jul 02.