In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters.

Autor: Najjar A; Beiersdorf AG, Beiersdorfstr. 1-9, 20245, Hamburg, Germany. Abdulkarim.Najjar@Beiersdorf.com., Grégoire S; L'Oreal Research & Innovation, Aulnay-Sous-Bois, France., Nicol B; Safety and Environmental Assurance Centre, Unilever UK, Colworth Science Park, MK44 1LQ, Sharnbrook, United Kingdom., Natsch A; Givaudan Schweiz AG, CH-8310, Kemptthal, Switzerland., Golbamaki N; L'Oreal Research & Innovation, Aulnay-Sous-Bois, France., Boisleve F; Chanel, Neuilly, France., Irizar A; The International Fragrance Association (IFRA), Geneva, Switzerland., Wall B; Colgate-Palmolive Company, Piscataway, NJ, 08854, USA., Swinscoe A; Whitman Laboratories, The Estée Lauder Companies, Petersfield, United Kingdom., Masini-Etévé V; L'Oréal Recherche & Innovation, Clichy, France., Selechnik D; Research Institute for Fragrance Materials (RIFM), Inc., Woodcliff Lake, NJ, USA., Api AM; Research Institute for Fragrance Materials (RIFM), Inc., Woodcliff Lake, NJ, USA., Griem P; Symrise AG, Holzminden, Germany., Hewitt N; SWS, Erzhausen, Germany., Cardamone E; Cosmetics Europe, Brussels, Belgium.

Publikováno v: Archives of toxicology [Arch Toxicol] 2024 Jul; Vol. 98 (7), pp. 2199-2211. Date of Electronic Publication: 2024 Apr 24.

P08-10 Advancing the use of New Approach Methodologies for assessing teratogenicity using a tiered approach: metabolism consideration to improve the human relevance

Autor: Asal, A., Gautier, F., Noel-voisin, A., Golbamaki, N., Detroyer, A., Bringel, T., Guillet-Revol, L., Carron, L., De Croze, N., Leonard, M., Ouedraogo, G., Burbank, M.

Publikováno v: In Toxicology Letters September 2024 399 Supplement 2:S177-S178

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Integrate mechanistic evidence from new approach methodologies (NAMs) into a read-across assessment to characterise trends in shared mode of action.

Autor: Escher SE; Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Germany. Electronic address: sylvia.escher@item.fraunhofer.de., Aguayo-Orozco A; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Denmark., Benfenati E; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy., Bitsch A; Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Germany., Braunbeck T; Aquatic Ecology and Toxicology Group, Center for Organismal Studies, University of Heidelberg, Heidelberg, Germany., Brotzmann K; Aquatic Ecology and Toxicology Group, Center for Organismal Studies, University of Heidelberg, Heidelberg, Germany., Bois F; Certara UK Ltd, Simcyp Division, Sheffield, United Kingdom., van der Burg B; BioDetection Systems, Amsterdam, the Netherlands., Castel J; Instituto de Investigación Sanitaria La Fe, University of Valencia, Spain, CIBEREH., Exner T; Edelweiss Connect GmbH, Basel, Switzerland., Gadaleta D; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy., Gardner I; Certara UK Ltd, Simcyp Division, Sheffield, United Kingdom., Goldmann D; University of Vienna, Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Vienna, Austria., Hatley O; Certara UK Ltd, Simcyp Division, Sheffield, United Kingdom., Golbamaki N; Lhasa Limited, Leeds, United Kingdom., Graepel R; Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands., Jennings P; Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Limonciel A; Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Long A; Lhasa Limited, Leeds, United Kingdom., Maclennan R; Cyprotex, Cheshire, United Kingdom., Mombelli E; Institut national de l'environnement industriel et des risques, France., Norinder U; MTM Research Centre, Örebro University, Sweden., Jain S; University of Vienna, Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Vienna, Austria., Capinha LS; Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Taboureau OT; Université de Paris, France., Tolosa L; Instituto de Investigación Sanitaria La Fe, University of Valencia, Spain, CIBEREH., Vrijenhoek NG; Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands., van Vugt-Lussenburg BMA; BioDetection Systems, Amsterdam, the Netherlands., Walker P; Cyprotex, Cheshire, United Kingdom., van de Water B; Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, the Netherlands., Wehr M; Fraunhofer Institute for Toxicology and Experimental Medicine, Chemical Safety and Toxicology, Germany., White A; Unilever Safety and Environmental Assurance Centre, Sharnbrook, Bedfordshire, United Kingdom., Zdrazil B; University of Vienna, Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Vienna, Austria., Fisher C; Certara UK Ltd, Simcyp Division, Sheffield, United Kingdom.

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2022 Mar; Vol. 79, pp. 105269. Date of Electronic Publication: 2021 Oct 29.

Review of New Approach Methodologies for Application in Risk Assessment of Nanoparticles in the Food and Feed Sector: Status and Challenges.

Autor: Usmani, Shirin M.¹ (AUTHOR) MESE@efsa.europa.eu, Bremer‐Hoffmann, Susanne² (AUTHOR), Cheyns, Karlien³ (AUTHOR), Cubadda, Francesco⁴ (AUTHOR), Dumit, Verónica I.¹ (AUTHOR), Escher, Sylvia E.⁵ (AUTHOR), Fessard, Valerie⁶ (AUTHOR), Gutleb, Arno C.⁷ (AUTHOR), Léger, Thibaut⁶ (AUTHOR), Liu, Yuk‐Chien¹ (AUTHOR), Mast, Jan³ (AUTHOR), McVey, Emily⁸ (AUTHOR), Mertens, Birgit³ (AUTHOR), Montalvo, Daniela³ (AUTHOR), Oomen, Agnes G.^8,9 (AUTHOR), Ritz, Vera¹ (AUTHOR), Serchi, Tommaso⁷ (AUTHOR), Sieg, Holger¹ (AUTHOR), Siewert, Katherina¹ (AUTHOR), Stanco, Deborah² (AUTHOR)

Publikováno v: EFSA Supporting Publications. Sep2024, Vol. 21 Issue 9, p1-178. 178p.