Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Golareh Agha"'
Autor:
Tianxiao Huan, Roby Joehanes, Ci Song, Fen Peng, Yichen Guo, Michael Mendelson, Chen Yao, Chunyu Liu, Jiantao Ma, Melissa Richard, Golareh Agha, Weihua Guan, Lynn M. Almli, Karen N. Conneely, Joshua Keefe, Shih-Jen Hwang, Andrew D. Johnson, Myriam Fornage, Liming Liang, Daniel Levy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Differentially methylated CpGs can inform on disease mechanisms and be useful as biomarkers. Here, the authors perform GWAS for DNA methylation in whole blood, cis- and trans-meQTL mapping, followed by Mendelian randomization analysis that links meQT
Externí odkaz:
https://doaj.org/article/7bdd0cfeebb44d3cb05a48f945dae102
Autor:
Cavin K. Ward-Caviness, Golareh Agha, Brian H. Chen, Liliane Pfeiffer, Rory Wilson, Petra Wolf, Christian Gieger, Joel Schwartz, Pantel S. Vokonas, Lifang Hou, Allan C. Just, Stefania Bandinelli, Dena G. Hernandez, Andrew B. Singleton, Holger Prokisch, Thomas Meitinger, Gabi Kastenmüller, Luigi Ferrucci, Andrea A. Baccarelli, Melanie Waldenberger, Annette Peters
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background Most research into myocardial infarctions (MIs) have focused on preventative efforts. For survivors, the occurrence of an MI represents a major clinical event that can have long-lasting consequences. There has been little to no re
Externí odkaz:
https://doaj.org/article/8a82bed9ae164deabd7f8ede0420e514
Autor:
Jian V. Huang, Andres Cardenas, Elena Colicino, C. Mary Schooling, Sheryl L. Rifas-Shiman, Golareh Agha, Yinan Zheng, Lifang Hou, Allan C. Just, Augusto A. Litonjua, Dawn L. DeMeo, Xihong Lin, Emily Oken, Marie-France Hivert, Andrea A. Baccarelli
Publikováno v:
Epigenetics, Vol 13, Iss 10-11, Pp 1072-1087 (2018)
Obesity is associated with higher cardio-metabolic risk even in childhood and adolescence; whether this association is mediated by epigenetic mechanisms remains unclear. We examined the extent to which mid-childhood body mass index (BMI) z-score (med
Externí odkaz:
https://doaj.org/article/fd3b4a2a409646eb9c50e1faa91e7c5a
Autor:
Andres Cardenas, Sheryl L. Rifas-Shiman, Golareh Agha, Marie-France Hivert, Augusto A. Litonjua, Dawn L. DeMeo, Xihong Lin, Chitra J. Amarasiriwardena, Emily Oken, Matthew W. Gillman, Andrea A. Baccarelli
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Prenatal exposure to mercury, a known neurotoxic metal, is associated with lower cognitive performance during childhood. Disruption of fetal epigenetic programming could explain mercury’s neurodevelopmental effects. We screened for epigeno
Externí odkaz:
https://doaj.org/article/34d1f356b4af4b6da9e45b49926acd1a
Autor:
Michael M. Mendelson, Golareh Agha, Fen Peng, Lynn M. Almli, Chunyu Liu, Shih-Jen Hwang, Karen N. Conneely, Ci Song, Andrew D. Johnson, Yichen Guo, Melissa A. Richard, Liming Liang, Tianxiao Huan, Myriam Fornage, Weihua Guan, Daniel Levy, Jiantao Ma, Joshua Keefe, Chen Yao, Roby Joehanes
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
Identifying methylation quantitative trait loci (meQTLs) and integrating them with disease-associated variants from genome-wide association studies (GWAS) may illuminate functional mechanisms underlying genetic variant-disease associations. Here, we
Autor:
Yen-Tsung Huang, Golareh Agha, Stephen L. Buka, Marcia P. Jimenez, Stephen E. Gilman, Su H. Chu, Risë B. Goldstein, Charles B. Eaton, Eric B. Loucks, Karl T. Kelsey
Publikováno v:
International Journal of Epidemiology. 48:98-107
Background Early exposure to socioeconomic disadvantage is associated with obesity. Here we investigated how early, and conducted mediation analyses to identify behavioural factors in adulthood that could explain why. Methods Among 931 participants i
Autor:
Stephen L. Buka, Karl T. Kelsey, Su H. Chu, Golareh Agha, Eric B. Loucks, Yen-Tsung Huang, Stephen E. Gilman, Charles B. Eaton
Publikováno v:
Epigenomics. 10:707-722
Aim: The objective of this study was to identify potential epigenetic mediating pathways linking early life social disadvantage (ELSD) to adulthood BMI. Methods: Sex-specific epigenome-wide two-stage mediation analyses were conducted in blood and adi
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Publikováno v:
Current environmental health reports. 6(1)
Epigenetic modifications are environmentally responsive and may play a mechanistic role in the development of disease. Mendelian randomization uses genetic variation to assess the causal effect of modifiable exposures on health outcomes. We conducted
Autor:
Symen Ligthart, Luigi Ferrucci, Rosario Tumino, Kerri L. Wiggins, Bruce M. Psaty, Dena G. Hernandez, Philip S. Tsao, Kelly M. Bakulski, Roby Joehanes, Tianxiao Huan, Steven Horvath, Luke C. Pilling, Eric Boerwinkle, Simone Wahl, Annette Peters, Vittorio Krogh, Devin Absher, Myriam Fornage, M. Daniele Fallin, Cavin K. Ward-Caviness, Elena Colicino, Nona Sotoodehnia, Michael M. Mendelson, Lifang Hou, Chunyu Liu, Pantel S. Vokonas, Carlotta Sacerdote, Abbas Dehghan, Andrew P. Feinberg, Jerome I. Rotter, Yun Li, Themistocles L. Assimes, Jennifer A. Brody, Rahul Gondalia, Andrea A. Baccarelli, Christian Gieger, Guosheng Zhang, Jan Bressler, Salvatore Panico, Stefania Bandinelli, Amy R. Vandiver, James S. Floyd, Michael L. Multhaup, Brian H. Chen, Elias Salfati, Giuseppe Matullo, James D. Stewart, Toshiko Tanaka, Joel Schwartz, Daniel Levy, Simonetta Guarrera, Allan C. Just, Andrew B. Singleton, Golareh Agha, Joel N. Hirschhorn, Eric A. Whitsel, Giovanni Fiorito
Publikováno v:
Circulation, 140(8), 645-657. Lippincott Williams & Wilkins
Circulation 140, 645-657 (2019)
Circulation 140, 645-657 (2019)
Background: DNA methylation is implicated in coronary heart disease (CHD), but current evidence is based on small, cross-sectional studies. We examined blood DNA methylation in relation to incident CHD across multiple prospective cohorts. Methods: Ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a13eff99f33decc0b18eb40d5716c50
https://pure.eur.nl/en/publications/765c4751-2215-4382-9742-855c69e4ff5e
https://pure.eur.nl/en/publications/765c4751-2215-4382-9742-855c69e4ff5e