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Quantitative Analysis of Delta-like 1 Membrane Dynamics Elucidates the Role of Contact Geometry on Notch Signaling

Autor: Khait, Itzhak, Orsher, Yuval, Golan, Ohad, Binshtok, Udi, Gordon-Bar, Nadav, Amir-Zilberstein, Liat, Sprinzak, David

Publikováno v: In Cell Reports 12 January 2016 14(2):225-233

Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism.

Autor: Kuang Y; Graduate Program in Molecular and Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, United States., Golan O; School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel., Preusse K; Division of Developmental Biology, Cincinnati Children's Hospital, Cincinnati, United States., Cain B; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, United States., Christensen CJ; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, United States., Salomone J; Graduate Program in Molecular and Developmental Biology, Cincinnati Children's Hospital Research Foundation, Cincinnati, United States.; Medical-Scientist Training Program, University of Cincinnati College of Medicine, Cincinnati, United States., Campbell I; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, United States., Okwubido-Williams FV; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, United States., Hass MR; Division of Developmental Biology, Cincinnati Children's Hospital, Cincinnati, United States., Yuan Z; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, United States., Eafergan N; School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel., Moberg KH; Department of Cell Biology, Emory University and Emory University School of Medicine, Atlanta, United States., Kovall RA; Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, United States., Kopan R; Division of Developmental Biology, Cincinnati Children's Hospital, Cincinnati, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States., Sprinzak D; School of Neurobiology, Biochemistry and Biophysics, George S. Wise Faculty of Life Science, Tel Aviv University, Tel Aviv, Israel., Gebelein B; Division of Developmental Biology, Cincinnati Children's Hospital, Cincinnati, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States.

Publikováno v: ELife [Elife] 2020 Apr 16; Vol. 9. Date of Electronic Publication: 2020 Apr 16.