Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Gokul Raj, Kathamuthu"'
Autor:
Berit Carow, Victoria Muliadi, Kristina Skålén, Chika Yokota, Gokul Raj Kathamuthu, Todia Pediatama Setiabudiawan, Christoph Lange, Katrin Scheu, Karoline I. Gaede, Torsten Goldmann, Ankur Pandita, Kiran Iqbal Masood, Shahid Pervez, Johan Grunewald, Zahra Hasan, Max Levin, Martin E. Rottenberg
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Tuberculosis (TB) and sarcoidosis are both granulomatous diseases. Here, we compared the immunological microenvironments of granulomas from TB and sarcoidosis patients using in situ sequencing (ISS) transcriptomic analysis and multiplexed immunolabel
Externí odkaz:
https://doaj.org/article/e50ca85cbb8f49688503a2602e0ba284
Autor:
Gokul Raj Kathamuthu, Anuradha Rajamanickam, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Soil-transmitted helminth [mainly Strongyloidiasis stercoralis (Ss)] and tuberculous lymphadenitis (TBL) coinfection in humans is a significant public health problem. We have previously shown that TBL+Ss+ coinfection significantly alters diverse cyto
Externí odkaz:
https://doaj.org/article/488bf0d42ddd46acb2c1a891eaebdfb6
Autor:
Gokul Raj Kathamuthu, Perumal Kannabiran Bhavani, Manjula Singh, Jitendra Kumar Saini, Ashutosh Aggarwal, Mohammed Soheb S. Ansari, Rajiv Garg, Subash Babu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
High-dose rifampicin (HDR) is now undergoing clinical trials to improve the efficacy of anti-tuberculosis treatment (ATT). However, the influence of HDR in the modulation of different cytokines, chemokines/growth factors, microbial translocation mark
Externí odkaz:
https://doaj.org/article/fa0eff977bb94f738add74ff6d1a9117
Autor:
Pavithra Sampath, Alangudi Palaniappan Natarajan, Kadar Moideen, Gokul Raj Kathamuthu, Syed Hissar, Madhavan Dhanapal, Lavanya Jayabal, Paranchi Murugesan Ramesh, Srikanth Prasad Tripathy, Uma Devi Ranganathan, Subash Babu, Ramalingam Bethunaickan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The rampant increase in drug-resistant tuberculosis (TB) remains a major challenge not only for treatment management but also for diagnosis, as well as drug design and development. Drug-resistant mycobacteria affect the quality of life owing to the d
Externí odkaz:
https://doaj.org/article/884cb712746344bf8c05241be6f60395
Autor:
Shanmugam Sivakumar, Yuvaraj Chandramohan, Gokul Raj Kathamuthu, Gomathi Sekar, Devika Kandhasamy, Venkatesan Padmanaban, Syed Hissar, Srikanth P. Tripathy, Ramalingam Bethunaickan, Baskaran Dhanaraj, Subash Babu, Uma Devi Ranganathan
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Tuberculosis (TB) though primarily affects the lungs it may also affect the other parts of the body and referred as extra pulmonary (EPTB). This study is focused on understanding the genetic diversity and molecular epidemiology of
Externí odkaz:
https://doaj.org/article/5a2c55dc0a6648ebb7d32a44bc55dc36
Publikováno v:
Journal of Immunology Research, Vol 2022 (2022)
Natural killer (NK) and invariant NKT (iNKT) cells are unique innate lymphocytes that coordinate diverse immune responses and display antimycobacterial potential. However, the role of NK and iNKT cells expressing cytokines, cytotoxic, and immune mark
Externí odkaz:
https://doaj.org/article/fbd521ff77ac4561b07c4d394b717905
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0269109 (2022)
Lymph node culture-positive tuberculosis (LNTB+) is associated with increased mycobacterial antigen-induced pro-inflammatory cytokine production compared to LN culture-negative tuberculosis (LNTB-). However, the frequencies of CD4+, CD8+ T cells and
Externí odkaz:
https://doaj.org/article/9cb4636c62dd4479a0099cb182c6bc33
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 8, Iss 3, p 150 (2023)
Pro-inflammatory cytokines are potent stimulators of inflammation and immunity and markers of infection severity and bacteriological burden in pulmonary tuberculosis (PTB). Interferons could have both host-protective and detrimental effects on tuberc
Externí odkaz:
https://doaj.org/article/21fd4e5ec9f1488ca725670d92b47c94
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Antigen-specific gamma-delta (γδ) T cells are important in exhibiting anti-mycobacterial immunity, but their role in latent tuberculosis (LTB) with diabetes mellitus (DM) or pre-DM (PDM) and non-DM comorbidities have not been studied. Thus, we have
Externí odkaz:
https://doaj.org/article/95154bd01ae547a7a06080daf4454a96
Autor:
Gokul Raj Kathamuthu, Kadar Moideen, Kannan Thiruvengadam, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Matrix metalloproteinases (MMPs) are crucial for tissue remodeling and repair and are expressed in diverse infections, whereas tissue inhibitors of metalloproteinases (TIMPs) are endogenous inhibitors of MMPs. However, the interaction of MMPs and TIM
Externí odkaz:
https://doaj.org/article/d8343a39b88c4aa3a2609af40496f455