Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Gokben Yildirir"'
Autor:
Arnab Roy Chowdhury, Rahul Bakshi, Jianyang Wang, Gokben Yildirir, Beiyu Liu, Valeria Pappas-Brown, Gökhan Tolun, Jack D Griffith, Theresa A Shapiro, Robert E Jensen, Paul T Englund
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001226 (2010)
Introduced in the 1950s, ethidium bromide (EB) is still used as an anti-trypanosomal drug for African cattle although its mechanism of killing has been unclear and controversial. EB has long been known to cause loss of the mitochondrial genome, named
Externí odkaz:
https://doaj.org/article/fb8e2012b7964a0091c8eb39ae88ecf7
Publikováno v:
PLoS Pathogens, Vol 5, Iss 9, p e1000589 (2009)
Trypanosoma brucei's mitochondrial genome, kinetoplast DNA (kDNA), is a giant network of catenated DNA rings. The network consists of a few thousand 1 kb minicircles and several dozen 23 kb maxicircles. Here we report that TbPIF5, one of T. brucei's
Externí odkaz:
https://doaj.org/article/de60ed4e0caf415d8577722b60ccf34f
Autor:
Hailun Wang, Dean W. Felsher, Natasha E. Zachara, Phuoc T. Tran, Kenneth J. Pienta, Katriana Nugent, Brian W. Simons, Jennifer Groves, Bin Zhang, Barry D. Nelkin, Xing Wang, Ken Wang, Gokben Yildirir, Audrey Lafargue, Mustafa A. Barbhuiya, Takumi Shiraishi, John Wong, Matthew Ballew, Kekoa Taparra, Reem Malek, James E. Verdone, Russell Williams, Roger Henry
Publikováno v:
Molecular Cancer Research. 18:B11-B11
Mutant KRAS drives glycolytic flux in lung cancer, potentially impacting aberrant protein glycosylation. Recent evidence suggests aberrant KRAS drives flux of glucose into the hexosamine biosynthetic pathway (HBP). HBP is required for various glycosy
Autor:
Katriana Nugent, James E. Verdone, Hailun Wang, Phuoc T. Tran, Mustafa A. Barbhuiya, Takumi Shiraishi, Bin Zhang, Russell Williams, Barry D. Nelkin, Natasha E. Zachara, Roger Henry, Kekoa Taparra, Reem Malek, Kenneth J. Pienta, Audrey Lafargue, Ken Kang Hsin Wang, John Wong, Matthew Ballew, Jennifer Groves, Gokben Yildirir, Dean W. Felsher, Brian W. Simons, Xing Wang
Publikováno v:
The Journal of clinical investigation. 128(11)
Mutant KRAS drives glycolytic flux in lung cancer, potentially impacting aberrant protein glycosylation. Recent evidence suggests aberrant KRAS drives flux of glucose into the hexosamine biosynthetic pathway (HBP). HBP is required for various glycosy
Autor:
Gokben Yildirir, Phuoc T. Tran, Brian W. Simons, Natasha E. Zachara, Jen Groves, Katriana Nugent, Hailun Wang, Dean W. Felsher, Kekoa Taparra, Reem Malek
Publikováno v:
Cancer Research. 76:1054-1054
Lung cancer is the deadliest and most common malignancy worldwide. Tumor invasion and metastasis influence the dismal 16% overall 5-year survival. Evidence suggests malignancies commandeer epithelial plasticity programs like the epithelial-mesenchyma
Publikováno v:
Cell stresschaperones. 18(5)
O-linked N-acetyl-β-d-glucosamine (O-GlcNAc) is a ubiquitous and dynamic post-translational modification known to modify over 3,000 nuclear, cytoplasmic, and mitochondrial eukaryotic proteins. Addition of O-GlcNAc to proteins is catalyzed by the O-G
Autor:
Valeria Pappas-Brown, Gökhan Tolun, Rahul P. Bakshi, Arnab Roy Chowdhury, Theresa A. Shapiro, Gokben Yildirir, Jack D. Griffith, Paul T. Englund, Jianyang Wang, Beiyu Liu, Robert E. Jensen
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001226 (2010)
PLoS Pathogens
PLoS Pathogens
Introduced in the 1950s, ethidium bromide (EB) is still used as an anti-trypanosomal drug for African cattle although its mechanism of killing has been unclear and controversial. EB has long been known to cause loss of the mitochondrial genome, named
Publikováno v:
The Journal of biological chemistry. 285(10)
Kinetoplast DNA, the trypanosome mitochondrial genome, is a network of interlocked DNA rings including several thousand minicircles and a few dozen maxicircles. Minicircles replicate after release from the network, and their progeny reattach. Remarka
Autor:
Shawn A. Motyka, Beiyu Liu, Megan E. Lindsay, Paul T. Englund, Yanan Liu, Eddy Chukwura Agbo, Gokben Yildirir, Zhixing Zhao
Publikováno v:
Biochemical Society transactions. 33(Pt 6)
African trypanosomes have a remarkable mitochondrial DNA termed kDNA (kinetoplast DNA) that contains several thousands of topologically interlocked DNA rings. Because of its highly unusual structure, kDNA has a complex replication mechanism. Our appr