Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Goichi Honda"'
Autor:
Yoshimi Kiyozumi, Hiroyuki Matsubayashi, Akiko Todaka, Ryo Ashida, Seiichiro Nishimura, Nobuhiro Kado, Satomi Higashigawa, Rina Harada, Eiko Ishihara, Yasue Horiuchi, Goichi Honda, Hirotsugu Kenmotsu, Masakuni Serizawa, Kenichi Urakami
Publikováno v:
Hereditary Cancer in Clinical Practice, Vol 22, Iss 1, Pp 1-6 (2024)
Abstract Background Germline mutations in CDKN2A result in Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM) (OMIM #155,601), which is associated with an increased risk of pancreatic ductal adenocarcinoma and melanoma. FAMMM has been reported
Externí odkaz:
https://doaj.org/article/966382f228df41918283c86a0c581114
Autor:
Hideo Wada, Kazuo Kawasugi, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Seiji Madoiwa, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Toshiaki Iba, Kohji Okamoto
Publikováno v:
TH Open, Vol 07, Iss 01, Pp e65-e75 (2023)
Abstract Background Disseminated intravascular coagulation (DIC) is not a homogeneous condition, but rather includes heterogeneous conditions, and its pathophysiology and outcome vary considerably depending on the background. Although anticoagulant
Externí odkaz:
https://doaj.org/article/0fadba14e37e45bf84126d976b253e62
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-8 (2021)
Abstract Background During sepsis or sterile tissue injury, the nuclear protein high mobility group box 1 (HMGB1) can be released to the extracellular space and ultimately into systemic circulation, where it mediates systemic inflammation and remote
Externí odkaz:
https://doaj.org/article/06a6f482f8fb4460b4d149a4f587ae52
Autor:
Kazuo Kawasugi, Hideo Wada, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Seiji Madoiwa, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Toshiaki Iba, Kohji Okamoto
Publikováno v:
Thrombosis Journal, Vol 19, Iss 1, Pp 1-7 (2021)
Abstract Background In patients with infectious diseases, disseminated intravascular coagulation (DIC) is often diagnosed without the fibrinogen value. The relationship between hypofibrinogenemia and outcomes of DIC in infectious diseases has thus re
Externí odkaz:
https://doaj.org/article/e3b3c1e6e832443b972da6714f07c7af
Autor:
Takashi Ito, Ikuro Maruyama, Shuji Shimazaki, Yasuhiro Yamamoto, Naoki Aikawa, Akio Hirayama, Goichi Honda, Hidehiko Saito
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 7, Pp 1141-1149 (2020)
Abstract Background The efficacy and safety of thrombomodulin alfa (TM‐α), a cofactor protein promoting thrombin‐mediated protein C activation, have been examined in a phase 3 randomized, double‐blinded, parallel‐group trial in Japan. We hav
Externí odkaz:
https://doaj.org/article/d5ebd439b6bc4e76827a7b06f5e957e1
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis, Vol 28 (2022)
Thrombomodulin alfa (TM-α, recombinant human soluble thrombomodulin) and antithrombin (AT) concentrate are anticoagulant agents for the treatment of disseminated intravascular coagulation (DIC). A post hoc analysis using data from 1198 patients with
Externí odkaz:
https://doaj.org/article/834e1027587b4f8a859fb41ada46fda8
Autor:
Eizo Watanabe, Osamu Takasu, Youichi Teratake, Teruo Sakamoto, Toshiaki Ikeda, Joji Kotani, Nobuya Kitamura, Masaaki Ohmori, Ayako Teratani, Goichi Honda, Masahiko Hatano, Benjamin Mayer, E. Marion Schneider, Shigeto Oda
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
Objective: Disseminated intravascular coagulation plays a key role in the pathophysiology of sepsis. Thrombomodulin is essential in the protein C system of coagulation cascade, and functional polymorphisms influence the human thrombomodulin gene (THB
Externí odkaz:
https://doaj.org/article/99d6fff5274d446188e2926fab5816d2
Autor:
Seki Yoshinobu MD, PhD, Goichi Honda PhD, Noriaki Kawano MD, PhD, Toshimasa Uchiyama MD, PhD, Kazuo Kawasugi MD, PhD, Seiji Madoiwa MD, PhD, Naoki Takezako MD, PhD, Ikezoe Takayuki MD, PhD, Hideo Wada MD, PhD
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis, Vol 27 (2021)
The aims of this study were to analyze the clinical features of a large number of cases with disseminated intravascular coagulation (DIC) associated with acute leukemia and to assess the safety and efficacy of thrombomodulin alfa (TM-α) using the Fr
Externí odkaz:
https://doaj.org/article/3506b2808fc24351a43a03d925724d94
Autor:
Hideo Wada MD, PhD, Goichi Honda PhD, Noriaki Kawano MD, PhD, Toshimasa Uchiyama MD, PhD, Kazuo Kawasugi MD, PhD, Seiji Madoiwa MD, PhD, Naoki Takezako MD, PhD, Kei Suzuki MD, PhD, Yoshinobu Seki MD, PhD, Takayuki Ikezoe MD, PhD, Toshiaki Iba MD, PhD, Kohji Okamoto MD, PhD
Publikováno v:
Clinical and Applied Thrombosis/Hemostasis, Vol 26 (2020)
The frequency of severe antithrombin deficiency (SAD) was examined in the hematopoietic disorder-, infectious-, and basic-types of the disseminated intravascular coagulation (DIC). A posthoc analysis of 3008 DIC patients (infectious-type, 1794; hemat
Externí odkaz:
https://doaj.org/article/b343d7c838614d539efb7cff704b0374
Autor:
Bin Pan, Xiangmin Wang, Chie Nishioka, Goichi Honda, Akihito Yokoyama, Lingyu Zeng, Kailin Xu, Takayuki Ikezoe
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Thrombomodulin (TM) stimulates angiogenesis and protects vascular endothelial cells (ECs) via its fifth epidermal growth factor-like region (TME5); however, the cell surface receptor that mediates the pro-survival signaling activated by TM h
Externí odkaz:
https://doaj.org/article/cd8c9b4f5e79444090f11c54054dee9b