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Intratumoral STING agonist reverses immune evasion in PD-(L)1-refractory Merkel cell carcinoma: mechanistic insights from detailed biomarker analyses.

Autor: Pulliam T; Department of Dermatology, University of Washington School of Medicine, Seattle, Washington, USA., Jani S; Department of Dermatology, University of Washington School of Medicine, Seattle, Washington, USA., Goff PH; Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Radiation Oncology, University of Washington, Seattle, Washington, USA., Bhakuni R; Department of Dermatology, University of Washington School of Medicine, Seattle, Washington, USA., Tabachnick-Cherny S; Department of Dermatology, University of Washington School of Medicine, Seattle, Washington, USA., Smythe K; Fred Hutchinson Cancer Center, Seattle, Washington, USA., Seaton BW; Fred Hutchinson Cancer Center, Seattle, Washington, USA., Tachiki L; Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Division of Medical Oncology, University of Washington School of Medicine, Seattle, Washington, USA., Kulikauskas R; Department of Dermatology, University of Washington School of Medicine, Seattle, Washington, USA., Church C; Department of Dermatology, University of Washington School of Medicine, Seattle, Washington, USA., Koelle DM; Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, Washington, USA., Nghiem P; Department of Dermatology, University of Washington School of Medicine, Seattle, Washington, USA.; Fred Hutchinson Cancer Center, Seattle, Washington, USA., Bhatia S; Fred Hutchinson Cancer Center, Seattle, Washington, USA sbhatia@uw.edu.; Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.

Publikováno v: Journal for immunotherapy of cancer [J Immunother Cancer] 2024 Oct 14; Vol. 12 (10). Date of Electronic Publication: 2024 Oct 14.

Considerations Regarding Mohs Surgery for Early-Stage Merkel Cell Carcinoma.

Autor: Venna SS; Inova Schar Cancer Institute, Fairfax, Virginia., Goff PH; University of Washington, Seattle, Washington., Brownell I; National Institute of Health, Bethesda, Maryland.

Publikováno v: JAMA dermatology [JAMA Dermatol] 2024 May 01; Vol. 160 (5), pp. 580-581.

The Evolving Treatment Landscape of Merkel Cell Carcinoma.

Autor: Singh N; Department of Medicine, Division of Dermatology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, USA.; Virginia Tech Carilion School of Medicine, Roanoke, VA, USA., McClure EM; Department of Medicine, Division of Dermatology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, USA.; University of South Florida, Morsani College of Medicine, Tampa, FL, USA., Akaike T; Department of Medicine, Division of Dermatology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, USA., Park SY; Department of Medicine, Division of Dermatology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, USA., Huynh ET; Department of Medicine, Division of Dermatology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, USA., Goff PH; Department of Medicine, Division of Dermatology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, USA.; Department of Radiation Oncology, University of Washington, Seattle, WA, USA., Nghiem P; Department of Medicine, Division of Dermatology, University of Washington, 850 Republican Street, Box 358050, Seattle, WA, USA. pnghiem@uw.edu.

Publikováno v: Current treatment options in oncology [Curr Treat Options Oncol] 2023 Sep; Vol. 24 (9), pp. 1231-1258. Date of Electronic Publication: 2023 Jul 05.

Neoadjuvant Therapy Induces a Potent Immune Response to Sarcoma, Dominated by Myeloid and B Cells.

Autor: Goff PH; Department of Radiation Oncology, University of Washington Medicine, Seattle, Washington., Riolobos L; Department of Medicine, University of Washington Medicine, Seattle, Washington.; Department of Cancer Vaccine Institute, University of Washington Medicine, Seattle, Washington., LaFleur BJ; University of Arizona BIO5 Institute, Tucson, Arizona., Spraker MB; Department of Radiation Oncology, Washington University School of Medicine in St. Louis, St. Louis, Missouri., Seo YD; Department of Surgery, University of Washington Medicine, Seattle, Washington., Smythe KS; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington., Campbell JS; Sensei Biotherapeutics, Inc., Boston, Massachusetts., Pierce RH; Sensei Biotherapeutics, Inc., Boston, Massachusetts., Zhang Y; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., He Q; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington., Kim EY; Department of Radiation Oncology, University of Washington Medicine, Seattle, Washington., Schaub SK; Department of Radiation Oncology, University of Washington Medicine, Seattle, Washington., Kane GM; Department of Radiation Oncology, University of Washington Medicine, Seattle, Washington., Mantilla JG; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington., Chen EY; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington., Ricciotti R; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington., Thompson MJ; Department of Orthopedics and Sports Medicine, University of Washington, Seattle, Washington.; Seattle Cancer Care Alliance, Seattle, Washington., Cranmer LD; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Seattle Cancer Care Alliance, Seattle, Washington.; Department of Medical Oncology, University of Washington Medicine, Seattle, Washington., Wagner MJ; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Seattle Cancer Care Alliance, Seattle, Washington.; Department of Medical Oncology, University of Washington Medicine, Seattle, Washington., Loggers ET; Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Washington.; Seattle Cancer Care Alliance, Seattle, Washington.; Department of Medical Oncology, University of Washington Medicine, Seattle, Washington., Jones RL; Sarcoma, Royal Marsden Hospital NHS Trust/Institute of Cancer Research, London, United Kingdom., Murphy E; Merck & Co., Inc., Kenilworth, New Jersey., Blumenschein WM; Merck & Co., Inc., Kenilworth, New Jersey., McClanahan TK; Merck & Co., Inc., Kenilworth, New Jersey., Earls J; Cofactor Genomics, Inc., San Francisco, California., Flanagan KC; Cofactor Genomics, Inc., San Francisco, California., LaFranzo NA; Cofactor Genomics, Inc., San Francisco, California., Kim TS; Department of Surgery, University of Washington Medicine, Seattle, Washington., Pollack SM; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2022 Apr 14; Vol. 28 (8), pp. 1701-1711.