Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis

Autor: Ryzhakov, G, West, N, Franchini, F, Clare, S, Ilott, N, Sansom, S, Bullers, S, Pearson, C, Costain, A, Vaughan-Jackson, A, Goettel, J, Ermann, J, Horwitz, B, Buti, L, Lu, X, Mukhopadhyay, S, Snapper, S, Powrie, FM

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Ryzhakov, G, West, N R, Franchini, F, Clare, S, Ilott, N E, Sansom, S N, Bullers, S J, Pearson, C, Costain, A, Vaughan-Jackson, A, Goettel, J A, Ermann, J, Horwitz, B H, Buti, L, Lu, X, Mukhopadhyay, S, Snapper, S B & Powrie, F 2018, ' Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis ', Nature Communications, vol. 9, no. 1, 3797 . https://doi.org/10.1038/s41467-018-06085-5

Inflammatory bowel disease (IBD) are heterogenous disorders of the gastrointestinal tract caused by a spectrum of genetic and environmental factors. In mice, overlapping regions of chromosome 3 have been associated with susceptibility to IBD-like pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::892298def2fb7c3fd94596edf8234f9b
https://pubmed.ncbi.nlm.nih.gov/30228258

Spontaneous food allergy in Was ^−/− mice occurs independent of Fcε RI-mediated mast cell activation.

Autor: Lexmond, W. S., Goettel, J. A., Sallis, B. F., McCann, K., Rings, E. H. H. M., Jensen‐Jarolim, E., Nurko, S., Snapper, S. B., Fiebiger, E.

Publikováno v: Allergy; Dec2017, Vol. 72 Issue 12, p1916-1924, 9p

Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients.

Autor: Lexmond, W. S., Pardo, M., Rooney, K., Goettel, J. A., Snapper, S. B., Yen, E. H., Dehlink, E., Nurko, S., Fiebiger, E.

Publikováno v: Clinical & Experimental Allergy; Aug2013, Vol. 43 Issue 8, p902-913, 12p, 2 Diagrams, 6 Graphs

Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3

Autor: Edda Fiebiger, Scott B. Snapper, Jodie Ouahed, Maria Grazia Roncarolo, Wayne A. Marasco, Bruce H. Horwitz, Bonny Patel, Diane Mathis, Luigi D. Notarangelo, Subhabrata Biswas, Rosa Bacchetta, Aleixo M. Muise, Katelyn McCann, Jiusong Sun, Sung-Yun Pai, Ada Yeste, Laura Passerini, Jeremy A. Goettel, Dror S. Shouval, Christoph Klein, Francisco J. Quintana, Edgar L. Milford, Siyoung Yang, Willem S. Lexmond

Publikováno v: Blood. 125(25)

Mice reconstituted with a human immune system provide a tractable in vivo model to assess human immune cell function. To date, reconstitution of murine strains with human hematopoietic stem cells (HSCs) from patients with monogenic immune disorders h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e350c20b927f85885fe742a9ecdb376d
https://pubmed.ncbi.nlm.nih.gov/26089378