Zobrazeno 1 - 10
of 543
pro vyhledávání: '"Goedegebuure P"'
Autor:
Xia, Huiming, Hoang, My, Schmidt, Evelyn, Kiwala, Susanna, McMichael, Joshua, Skidmore, Zachary L., Fisk, Bryan, Song, Jonathan J., Hundal, Jasreet, Mooney, Thomas, Walker, Jason R., Goedegebuure, S. Peter, Miller, Christopher A., Gillanders, William E., Griffith, Obi L., Griffith, Malachi
Neoantigen targeting therapies including personalized vaccines have shown promise in the treatment of cancers. Accurate identification/prioritization of neoantigens is highly relevant to designing clinical trials, predicting treatment response, and u
Externí odkaz:
http://arxiv.org/abs/2406.06985
Autor:
Huiming Xia, My H. Hoang, Evelyn Schmidt, Susanna Kiwala, Joshua McMichael, Zachary L. Skidmore, Bryan Fisk, Jonathan J. Song, Jasreet Hundal, Thomas Mooney, Jason R. Walker, S. Peter Goedegebuure, Christopher A. Miller, William E. Gillanders, Obi L. Griffith, Malachi Griffith
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Neoantigen-targeting therapies including personalized vaccines have shown promise in the treatment of cancers, particularly when used in combination with checkpoint blockade therapy. At least 100 clinical trials involving these th
Externí odkaz:
https://doaj.org/article/01d72c65e37e4a128cc544c775252cbb
Autor:
Xiuli Zhang, S. Peter Goedegebuure, Michael Y. Chen, Rashmi Mishra, Felicia Zhang, Yik Yeung Yu, Kartik Singhal, Lijin Li, Feng Gao, Nancy B. Myers, Tammi Vickery, Jasreet Hundal, Michael D. McLellan, Mark A. Sturmoski, Samuel W. Kim, Ina Chen, Jesse T. Davidson, Narendra V. Sankpal, Stephanie Myles, Rama Suresh, Cynthia X. Ma, Ademuyiwa Foluso, Andrea Wang-Gillam, Sherri Davies, Ian S. Hagemann, Elaine R. Mardis, Obi Griffith, Malachi Griffith, Christopher A. Miller, Ted H. Hansen, Timothy P. Fleming, Robert D. Schreiber, William E. Gillanders
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II
Externí odkaz:
https://doaj.org/article/361f87535f3347da8e2cfda87d75ab59
Autor:
Madeleine Goedegebuure, Matthew I. Bury, Xinlong Wang, Pasquale Sanfelice, Federico Cammarata, Larry Wang, Tiffany T. Sharma, Nachiket Rajinikanth, Vikram Karra, Vidhika Siddha, Arun K. Sharma, Guillermo A. Ameer
Publikováno v:
Bioactive Materials, Vol 41, Iss , Pp 553-563 (2024)
Chronic bladder dysfunction due to bladder disease or trauma is detrimental to affected patients as it can lead to increased risk of upper urinary tract dysfunction. Current treatment options include surgical interventions that enlarge the bladder wi
Externí odkaz:
https://doaj.org/article/bfe054c49e4a4b7c8ae09fb2a6f13f69
Autor:
Goedegebuure, Abel, Kumara, Indika, Driessen, Stefan, Di Nucci, Dario, Monsieur, Geert, Heuvel, Willem-jan van den, Tamburri, Damian Andrew
Data mesh is an emerging domain-driven decentralized data architecture that aims to minimize or avoid operational bottlenecks associated with centralized, monolithic data architectures in enterprises. The topic has picked the practitioners' interest,
Externí odkaz:
http://arxiv.org/abs/2304.01062
Autor:
Lijun Yao, Bradley A. Krasnick, Ye Bi, Sunantha Sethuraman, Simon Goedegebuure, Amila Weerasinghe, Chris Wetzel, Qingsong Gao, Abimbola Oyedeji, Jacqueline Mudd, Matthew A. Wyczalkowski, Michael Wendl, Li Ding, Ryan C. Fields
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Therapy targeting the BRAF-MEK cascade created a treatment revolution for patients with BRAF mutant advanced melanoma. Unfortunately, 80% patients treated will progress by 5 years follow-up. Thus, it is imperative we study mechanisms of mela
Externí odkaz:
https://doaj.org/article/e331c71431eb4f70bc8969cf37914a5c
Publikováno v:
Australian and New Zealand Journal of European Studies, Vol 16, Iss 1/2 (2024)
In November 2019, the Victorian Government announced the Victorian Forestry Plan. It set out the gradual transition away from native forest harvesting to a plantation-based timber supply by 2030. A revised timeline was communicated in May 2023, bring
Externí odkaz:
https://doaj.org/article/293a8c37e3544374b59312528df62416
Autor:
Takaomi Hagi, Suwanna Vangveravong, Rony Takchi, Qingqing Gong, S. Peter Goedegebuure, Herve Tiriac, Brian A. Van Tine, Matthew A. Powell, William G. Hawkins, Dirk Spitzer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Cancer selective apoptosis remains a therapeutic challenge and off-target toxicity has limited enthusiasm for this target clinically. Sigma-2 ligands (S2) have been shown to enhance the cancer selectivity of small molecule drug candidates by
Externí odkaz:
https://doaj.org/article/9e2904ef921e408c9a9dcba07e068c79
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Dendritic cells (DCs) play a central role in the orchestration of effective T cell responses against tumors. However, their functional behavior is context-dependent. DC type, transcriptional program, location, intratumoral factors, and inflammatory m
Externí odkaz:
https://doaj.org/article/4b57a07e1bda42679b4295753dcebc0a
Autor:
Demi J. Dorrepaal, Wesley J. Goedegebuure, Manouk van der Steen, Daniel Bos, Anita C.S. Hokken – Koelega
Publikováno v:
EClinicalMedicine, Vol 72, Iss , Pp 102637- (2024)
Summary: Background: Increased cerebrovascular morbidity was reported in adults born small for gestational age (SGA) who were treated with growth hormone (GH) during childhood compared to the general population. Yet, previous studies lacked an approp
Externí odkaz:
https://doaj.org/article/0bb0c5b8c8204a25a9395c51fbc6d2c3