Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Godwin Dogbevia"'
Autor:
Jakob Körbelin, Godwin Dogbevia, Stefan Michelfelder, Dirk A Ridder, Agnes Hunger, Jan Wenzel, Henning Seismann, Melanie Lampe, Jacqueline Bannach, Manolis Pasparakis, Jürgen A Kleinschmidt, Markus Schwaninger, Martin Trepel
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 6, Pp 609-625 (2016)
Abstract Gene therapy critically relies on vectors that combine high transduction efficiency with a high degree of target specificity and that can be administered through a safe intravenous route. The lack of suitable vectors, especially for gene the
Externí odkaz:
https://doaj.org/article/b52f1692373e499a82e3aeb7fb5c9aef
Publikováno v:
J Cereb Blood Flow Metab
In Tay-Sachs and Sandhoff disease, a deficiency of the lysosomal enzyme β-hexosaminidase causes GM2 and other gangliosides to accumulate in neurons and triggers neurodegeneration. Although the pathology centers on neurons, β-hexosaminidase is mainl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a1267bd502b500e5238372a1668da2
https://doi.org/10.1177/0271678x19865917
https://doi.org/10.1177/0271678x19865917
Autor:
Dirk A. Ridder, Hanna Grasshoff, Wolfgang Löscher, Beate K. Straub, Martin Trepel, Jakob Körbelin, Sonja Bröer, Markus Schwaninger, Kathrin Töllner, Jan Wenzel, Godwin Dogbevia, Claudia Brandt
Publikováno v:
Annals of Neurology. 82:93-104
Objective: Incontinentia pigmenti (IP) is a genetic disease leading to severe neurological symptoms, such as epileptic seizures, but no specific treatment is available. IP is caused by pathogenic variants that inactivate the Nemo gene. Replacing Nemo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82d61bfe162dc45916b218c0cf36bf9e
https://doi.org/10.1002/ana.24981
https://doi.org/10.1002/ana.24981
Autor:
Androniki Raftogianni, Mazahir T. Hasan, Yannick Goumon, H. Sophie Knobloch-Bollmann, Virginie Chavant, Claudia Pitzer, Godwin Dogbevia, Ferdinand Althammer, Sabine C. Herpertz, Valery Grinevich, Xinying Liu, Rolf Sprengel, Jonas Schimmer, René Hurlemann, Damien Kerspern, Marina Eliava, Ilaria Bertocchi, Alexandre Charlet, Yan Tang, Pascal Darbon, Hilmar Bading, Jérôme Wahis, Apar Jain, Matthew E. Larkum, Miriam Silva da Gouveia, Jan-Marek Weislogel, Stéphanie Goyon, Arthur Lefevre
Publikováno v:
Neuron
Neuron, Elsevier, 2019, ⟨10.1016/j.neuron.2019.04.029⟩
Neuron, 2019, 103 (1), pp.133-146.e8. ⟨10.1016/j.neuron.2019.04.029⟩
Neuron, Elsevier, 2019, ⟨10.1016/j.neuron.2019.04.029⟩
Neuron, 2019, 103 (1), pp.133-146.e8. ⟨10.1016/j.neuron.2019.04.029⟩
Oxytocin (OT) release by axonal terminals onto the central nucleus of the amygdala exerts anxiolysis. To investigate which subpopulation of OT neurons contributes to this effect, we developed a novel method: virus-delivered genetic activity-induced t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e97ae237e2870f31a5a23df8edd4f0
https://hal.archives-ouvertes.fr/hal-02166001
https://hal.archives-ouvertes.fr/hal-02166001
Autor:
Mazahir T. Hasan, Elena Y. Bryleva, Stephanie R. Murphy, Zachary D. Bowen, Catherine C.Y. Chang, Ta-Yuan Chang, Godwin Dogbevia
Publikováno v:
Molecular Therapy. 21:1497-1506
Both genetic inactivation and pharmacological inhibition of the cholesteryl ester synthetic enzyme acyl-CoA:cholesterol acyltransferase 1 (ACAT1) have shown benefit in mouse models of Alzheimer's disease (AD). In this study, we aimed to test the pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82249744dd0e32e7d7d405c890b4211a
https://doi.org/10.1038/mt.2013.118
https://doi.org/10.1038/mt.2013.118
Autor:
Mazahir T. Hasan, Samuel Hernández-González, Godwin Dogbevia, Mario Treviño, Ilaria Bertocchi, Agnès Gruart, José M. Delgado-García
Publikováno v:
Nature Communications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd11fd9d3655de1342340858569cc2b7
https://doi.org/10.1038/ncomms3831
https://doi.org/10.1038/ncomms3831
Autor:
Samuel Hernández-González, Mazahir T. Hasan, Ilaria Bertocchi, Mario Treviño, José M. Delgado-García, Godwin Dogbevia, Agnès Gruart
Publikováno v:
Nature Communications; Vol 4
Nature Communications
Nature Communications
The primary motor cortex has an important role in the precise execution of learned motor responses. During motor learning, synaptic efficacy between sensory and primary motor cortical neurons is enhanced, possibly involving long-term potentiation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fafd6549eceac090f15fefadab795a
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Molecular Therapy Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Molecular Therapy Nucleic Acids
Controlling gene expression in mammalian brain is of utmost importance to causally link the role of gene function to cell circuit dynamics under normal conditions and disease states. We have developed recombinant adeno-associated viruses equipped wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56f62380b8422ffdab37bf6c01fe9ba
http://europepmc.org/articles/PMC5014524
http://europepmc.org/articles/PMC5014524
Autor:
Olaf Jöhren, Vincent Prevot, Kristina Kusche-Vihrog, Hanna Graßhoff, Rubén Nogueiras, Helge Müller-Fielitz, Godwin Dogbevia, Oliver J. Müller, Carl Mg Vahldieck, Markus Schwaninger, Jakob Körbelin, Jacqueline Bannach
Publikováno v:
J Cereb Blood Flow Metab
Gene vectors targeting CNS endothelial cells allow to manipulate the blood-brain barrier and to correct genetic defects in the CNS. Because vectors based on the adeno-associated virus (AAV) have a limited capacity, it is essential that the DNA sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfa287361ca950033695ea2354b4715