Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Godwin Akpeko, Dziwornu"'
Publikováno v:
Nature Reviews Chemistry. 7:340-354
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5df4ff0d305f1857af9fa326c207b002
https://doi.org/10.1038/s41570-023-00472-3
https://doi.org/10.1038/s41570-023-00472-3
Publikováno v:
Molecules, Vol 26, Iss 13, p 4093 (2021)
Molecular hybridization is a drug discovery strategy that involves the rational design of new chemical entities by the fusion (usually via a covalent linker) of two or more drugs, both active compounds and/or pharmacophoric units recognized and deriv
Externí odkaz:
https://doaj.org/article/79a462605be24f2e8cfd7b5c07a7fd98
Autor:
Caroline C. Sousa, Godwin Akpeko Dziwornu, Helenita C. Quadros, João Honorato Araujo-Neto, Kelly Chibale, Diogo R. M. Moreira
Publikováno v:
ACS Infectious Diseases. 8:1700-1710
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::671e1d3d5cfeedfd76214c8b9d321f8e
https://doi.org/10.1021/acsinfecdis.2c00326
https://doi.org/10.1021/acsinfecdis.2c00326
Autor:
Janette Reader, Kelly Chibale, Mariëtte van der Watt, Lyn-Marie Birkholtz, Henrico Langeveld, Peter Mubanga Cheuka, Godwin Akpeko Dziwornu, Dina Coertzen, Meta Leshabane
Publikováno v:
Transactions of the Royal Society of South Africa. 76:225-233
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3e62252a9c125413adfd2f5da4f361c
https://doi.org/10.1080/0035919x.2021.1982792
https://doi.org/10.1080/0035919x.2021.1982792
Publikováno v:
ACS Infectious Diseases. 7:2437-2444
Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a major global health concern given the increase in multiple forms of drug-resistant TB. This underscores the importance of a continuous pipeline of new anti-TB agents. Drug repurposing has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e97a4cd4b22b74e310632c4a4d2f5ef5
https://doi.org/10.1021/acsinfecdis.1c00195
https://doi.org/10.1021/acsinfecdis.1c00195
Autor:
Caroline C, Sousa, Godwin Akpeko, Dziwornu, Helenita C, Quadros, João Honorato, Araujo-Neto, Kelly, Chibale, Diogo R M, Moreira
Publikováno v:
ACS infectious diseases. 8(8)
Pyrido[1,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ffa04279705110164209e1f535c3b8ee
https://pubmed.ncbi.nlm.nih.gov/35848708
https://pubmed.ncbi.nlm.nih.gov/35848708
Autor:
Constance M. Korkor, Kelly Chibale, Godwin Akpeko Dziwornu, Sergio Wittlin, Dina Coertzen, Cleavon K Cloete, Meta Leshabane, Mathew Njoroge, Janette Reader, Nina Lawrence, Lyn-Marie Birkholtz, Liezl Gibhard, Mariëtte van der Watt
Publikováno v:
Journal of Medicinal Chemistry. 64:5198-5215
A novel series of antimalarial benzimidazole derivatives incorporating phenolic Mannich base side chains at the C2 position, which possess dual asexual blood and sexual stage activities, is presented. Structure-activity relationship studies revealed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b48aacb29375c8b07c5e4fbbf91b32a
https://doi.org/10.1021/acs.jmedchem.1c00354
https://doi.org/10.1021/acs.jmedchem.1c00354
Autor:
Mariëtte van der Watt, Richard Ferger, Consolata Nsanzubuhoro, Kelly Chisanga, Dina Coertzen, Meta Leshabane, Erica Erlank, Kelly Chibale, Phanankosi Moyo, Godwin Akpeko Dziwornu, Lyn-Marie Birkholtz, Nelius Venter, Lizette L. Koekemoer, Janette Reader
Publikováno v:
ACS Infectious Diseases. 7:1945-1955
The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are needed to treat patients and ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc5ec53918027e198adcacfdc7ed99c3
https://doi.org/10.1021/acsinfecdis.0c00910
https://doi.org/10.1021/acsinfecdis.0c00910
Autor:
Sergio Wittlin, Lynn Wambua, Luyanda Centani, Lauren B. Arendse, Lyn-Marie Birkholtz, Dale Taylor, Kelly Chibale, Janette Reader, Dina Coertzen, Nina Lawrence, Malkeet Kumar, Shoneeze S Renga, Peter Mubanga Cheuka, Stephen Fienberg, Godwin Akpeko Dziwornu, Mariëtte van der Watt
Publikováno v:
ACS Infectious Diseases. 7:34-46
Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df75b11c41574c2c365ab07859345b41
https://doi.org/10.1021/acsinfecdis.0c00481
https://doi.org/10.1021/acsinfecdis.0c00481
Autor:
Kelly Chibale, Alexandra Probst, Jennifer Keiser, Kelly Chisanga, Godwin Akpeko Dziwornu, Cécile Haeberli
Publikováno v:
ACS Infectious Diseases. 7:1032-1043
Praziquantel is the only widely available drug to treat schistosomiasis. With very few candidates currently in the drug development pipeline, there is an urgent need to discover and develop novel antischistosomal drugs. In this regard, the pyrido[1,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00b40fd85b8e5fb3812a8cdfaa39ad40
https://doi.org/10.1021/acsinfecdis.0c00278
https://doi.org/10.1021/acsinfecdis.0c00278