Antimicrobial activity of stigmasterol from the stem bark of Neocarya macrophylla

Autor: Amina J. Yusuf, Musa I. Abdullahi, Godwin A. Aleku, Ilyasu A.A. Ibrahim, Celestina O. Alebiosu, Maryam Yahaya, Hajara W. Adamu, Abdulrazaq Sanusi, Maria M. Mailafiya, Hassan Abubakar

Publikováno v: Journal of Medicinal Plants for Economic Development, Vol 2, Iss 1, Pp e1-e5 (2018)

Background: Natural products play a significant role in human therapy. They represent a huge reservoir of bioactive chemical diversity and help in understanding the cellular pathways that are essential component of drug discovery process. Objective

Externí odkaz: https://doaj.org/article/084e5c2876eb43288e216122263325f7

Synthetic Enzyme‐Catalyzed CO 2 Fixation Reactions

Autor: Godwin A. Aleku, George W. Roberts, David Leys, Gabriel R. Titchiner

Publikováno v: ChemSusChem
Aleku, G A, Roberts, G W, Titchiner, G R & Leys, D 2021, ' Synthetic enzyme-catalysed CO2 fixation reactions ', Chemsuschem . https://doi.org/10.1002/cssc.202100159

In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof-of-concept (bio)synthetic CO2 fixation routes for chemical production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981cef0d50780bd1bfa3ceda10cc1083
https://doi.org/10.1002/cssc.202100159

Ultrahigh-throughput screening in microfluidic droplets: a faster route to new enzymes

Autor: Godwin A. Aleku, Florian Hollfelder, Maximilian Gantz

Publikováno v: Trends in biochemical sciences. 47(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a1908332b6fc7540566b8e92dc1d964
https://pubmed.ncbi.nlm.nih.gov/34848125

Enzymatic C-H activation of aromatic compounds through CO

Autor: Godwin A, Aleku, Annica, Saaret, Ruth T, Bradshaw-Allen, Sasha R, Derrington, Gabriel R, Titchiner, Irina, Gostimskaya, Deepankar, Gahloth, David A, Parker, Sam, Hay, David, Leys

Publikováno v: Nature chemical biology. 16(11)

The direct C-H carboxylation of aromatic compounds is an attractive route to the corresponding carboxylic acids, but remains challenging under mild conditions. It has been proposed that the first step in anaerobic microbial degradation of recalcitran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79f836bfc8ca83acdbca69e2a4ae567d
https://pubmed.ncbi.nlm.nih.gov/32719558

Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing

Autor: Beatriz Dominguez, Godwin A. Aleku, Nicholas J. Turner, Juan Mangas-Sanchez, Sarah L. Montgomery, Matthew P. Thompson

Publikováno v: Montgomery, S L, Mangas-Sanchez, J, Thompson, M P, Aleku, G A, Dominguez, B & Turner, N J 2017, ' Direct Alkylation of Amines with Primary and Secondary Alcohols through Biocatalytic Hydrogen Borrowing ', Angewandte Chemie (International ed. in English), vol. 56, no. 35, pp. 10491-10494 . https://doi.org/10.1002/anie.201705848

The reductive aminase from Aspergillus oryzae (AspRedAm) was combined with a single alcohol dehydrogenase (either metagenomic ADH-150, an ADH from Sphingobium yanoikuyae (SyADH), or a variant of the ADH from Thermoanaerobacter ethanolicus (TeSADH W11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04808371205f9150286cb43af4323150
https://doi.org/10.1002/ange.201705848