Genetic Contributions to Alzheimer's Disease and Frontotemporal Dementia in Admixed Latin American Populations.

Autor: Acosta-Uribe J, Piña Escudero SD, Cochran JN, Taylor JW, Castruita PA, Jonson C, Barinaga EA, Roberts K, Levine AR, George DS, ÁvilaFunes JA, Behrens MI, Bruno MA, Brusco LI, Custodio N, Duran-Aniotz C, Lopera F, Matallana DL, Slachevsky A, Takada LT, Zapata-Restrepo LM, Durón-Reyes DE, França Resende EP, Gelvez N, Godoy ME, Maito MA, Javandel S, Miller BL, Nalls MA, Leonard H, Vitale D, Bandres-Ciga S, Koretsky MJ, Singleton AB, Pantazis CB, Valcour V, Ibañez A, Kosik KS, Yokoyama JS

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Nov 01. Date of Electronic Publication: 2024 Nov 01.

Author Correction: Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations.

Autor: Moguilner S; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Baez S; Universidad de los Andes, Bogota, Colombia.; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland., Hernandez H; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Migeot J; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Legaz A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Gonzalez-Gomez R; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Farina FR; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; The University of California Santa Barbara (UCSB), Santa Barbara, CA, USA., Prado P; Escuela de Fonoaudiología, Universidad San Sebastián, Santiago de Chile, Chile., Cuadros J; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Grupo de Bioingeniería, Decanato de Investigación, Universidad Nacional Experimental del Táchira, San Cristóbal, Venezuela.; Advanced Center for Electrical and Electronic Engineering, Universidad Técnica Federico Santa María, Valparaíso, Chile., Tagliazucchi E; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; University of Buenos Aires, Buenos Aires, Argentina., Altschuler F; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Maito MA; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Godoy ME; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Cruzat J; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Valdes-Sosa PA; The Clinical Hospital of Chengdu Brain Sciences Institute, University of Electronic Sciences and Technology of China, Chengdu, China.; Technology of China, Chengdu, China.; Cuban Neuroscience Center, La Habana, Cuba., Lopera F; Grupo de Neurociencias de Antioquia (GNA), University of Antioquia, Medellín, Colombia., Ochoa-Gómez JF; Grupo de Neurociencias de Antioquia (GNA), University of Antioquia, Medellín, Colombia., Hernandez AG; Department of Psychology, Master Program of Clinical Neuropsychology, Universidad Surcolombiana Neiva, Neiva, Colombia., Bonilla-Santos J; Department of Psychology, Universidad Cooperativa de Colombia, Arauca, Colombia., Gonzalez-Montealegre RA; Neurocognition and Psychophysiology Laboratory, Universidad Surcolombiana, Neiva, Colombia., Anghinah R; Reference Center of Behavioural Disturbances and Dementia, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.; Traumatic Brain Injury Cognitive Rehabilitation Out-Patient Center, University of Sao Paulo, Sao Paulo, Brazil., d'Almeida Manfrinati LE; Reference Center of Behavioural Disturbances and Dementia, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.; Traumatic Brain Injury Cognitive Rehabilitation Out-Patient Center, University of Sao Paulo, Sao Paulo, Brazil., Fittipaldi S; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland., Medel V; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Olivares D; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile.; Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Program-Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, University of Chile, Santiago, Chile.; Centro de Neuropsicología Clínica (CNC), Santiago, Chile., Yener GG; Faculty of Medicine, Izmir University of Economics, Izmir, Turkey.; Brain Dynamics Multidisciplinary Research Center, Dokuz Eylul University, Izmir, Turkey.; Izmir Biomedicine and Genome Center, Izmir, Turkey., Escudero J; School of Engineering, Institute for Imaging, Data and Communications, University of Edinburgh, Edinburgh, UK., Babiloni C; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy.; Hospital San Raffaele Cassino, Cassino, Italy., Whelan R; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; School of Psychology, Trinity College Dublin, Dublin, Ireland., Güntekin B; Department of Neurosciences, Health Sciences Institute, Istanbul Medipol University, İstanbul, Turkey.; Health Sciences and Technology Research Institute (SABITA), Istanbul Medipol University, Istanbul, Turkey.; Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Yırıkoğulları H; Department of Neurosciences, Health Sciences Institute, Istanbul Medipol University, İstanbul, Turkey.; Health Sciences and Technology Research Institute (SABITA), Istanbul Medipol University, Istanbul, Turkey., Santamaria-Garcia H; Pontificia Universidad Javeriana (PhD Program in Neuroscience), Bogotá, Colombia.; Center of Memory and Cognition Intellectus, Hospital Universitario San Ignacio Bogotá, San Ignacio, Colombia., Lucas AF; Departamento de Medicina Legal, Psiquiatría y Patología, Universidad Complutense de Madrid, Madrid, Spain., Huepe D; Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile., Di Caterina G; Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow, UK., Soto-Añari M; Universidad Católica San Pablo, Arequipa, Peru., Birba A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Sainz-Ballesteros A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Coronel-Oliveros C; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Universidad de Valparaíso, Valparaíso, Chile., Yigezu A; The University of California Santa Barbara (UCSB), Santa Barbara, CA, USA., Herrera E; Departamento de Estudios Psicológicos, Universidad ICESI, Cali, Colombia., Abasolo D; Centre for Biomedical Engineering, School of Mechanical Engineering Sciences, University of Surrey, Guildford, UK., Kilborn K; School of Psychology, University of Glasgow, Glasgow, UK., Rubido N; Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen, UK., Clark RA; Centre for Signal and Image Processing, Department of Electronic and Electrical Engineering, University of Strathclyde, Strathclyde, UK., Herzog R; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, InsermCNRS, Paris, France., Yerlikaya D; Department of Neurosciences, Health Sciences Institute, Dokuz Eylül University, Izmir, Turkey., Hu K; Harvard Medical School, Boston, MA, USA., Parra MA; Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK.; BrainLat, Universidad Adolfo Ibáñez, Santiago, Chile., Reyes P; Pontificia Universidad Javeriana (PhD Program in Neuroscience), Bogotá, Colombia.; Center of Memory and Cognition Intellectus, Hospital Universitario San Ignacio Bogotá, San Ignacio, Colombia., García AM; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Departamento de Lingüística y Literatura, Universidad de Santiago de Chile, Santiago, Chile., Matallana DL; Pontificia Universidad Javeriana (PhD Program in Neuroscience), Bogotá, Colombia.; Center of Memory and Cognition Intellectus, Hospital Universitario San Ignacio Bogotá, San Ignacio, Colombia.; Mental Health Department, Hospital Universitario Fundación Santa Fe, Bogota, Colombia., Avila-Funes JA; Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Slachevsky A; Memory and Neuropsychiatric Center (CMYN), Neurology Department, Hospital del Salvador and Faculty of Medicine, University of Chile, Santiago, Chile.; Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.; Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Program - Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, University of Chile, Santiago, Chile., Behrens MI; Neurology and Psychiatry Department, Clínica Alemana-Universidad Desarrollo, Santiago, Chile.; Centro de Investigación Clínica Avanzada (CICA), Universidad de Chile, Santiago, Chile.; Departamento de Neurología y Neurocirugía, Hospital Clínico de la Universidad de Chile, Santiago, Chile.; Departamento de Neurociencia, Universidad de Chile, Santiago, Chile., Custodio N; Servicio de Neurología, Instituto Peruano de Neurociencias, Lima, Perú., Cardona JF; Facultad de Psicología, Universidad del Valle, Cali, Colombia., Barttfeld P; Cognitive Science Group, Instituto de Investigaciones Psicológicas (IIPsi), CONICET UNC, Universidad Nacional de Córdoba, Córdoba, Argentina., Brusco IL; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina., Bruno MA; Instituto de Ciencias Biomédicas (ICBM), Universidad Catoóica de Cuyo, San Juan, Argentina., Sosa Ortiz AL; Instituto Nacional de Neurologia y Neurocirugia MVS, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico., Pina-Escudero SD; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Takada LT; Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil., Resende E; Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Possin KL; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., de Oliveira MO; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil., Lopez-Valdes A; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; School of Engineering, Department of Electrical and Electronic Engineering, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.; Trinity Centre for Biomedical Engineering, Trinity College Dublin, Dublin, Ireland., Lawlor B; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland., Robertson IH; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Kosik KS; Division of the Biological Sciences, The University of Chicago, Chicago, IL, USA., Duran-Aniotz C; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Valcour V; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Yokoyama JS; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Miller B; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Ibanez A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile. agustin.ibanez@gbhi.org.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina. agustin.ibanez@gbhi.org.; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA. agustin.ibanez@gbhi.org.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. agustin.ibanez@gbhi.org.

Publikováno v: Nature medicine [Nat Med] 2024 Sep 16. Date of Electronic Publication: 2024 Sep 16.

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations.

Autor: Moguilner S; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Baez S; Universidad de los Andes, Bogota, Colombia.; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland., Hernandez H; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Migeot J; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Legaz A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Gonzalez-Gomez R; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Farina FR; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; The University of California Santa Barbara (UCSB), Santa Barbara, CA, USA., Prado P; Escuela de Fonoaudiología, Universidad San Sebastián, Santiago de Chile, Chile., Cuadros J; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Grupo de Bioingeniería, Decanato de Investigación, Universidad Nacional Experimental del Táchira, San Cristóbal, Venezuela.; Advanced Center for Electrical and Electronic Engineering, Universidad Técnica Federico Santa María, Valparaíso, Chile., Tagliazucchi E; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; University of Buenos Aires, Buenos Aires, Argentina., Altschuler F; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Maito MA; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Godoy ME; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Cruzat J; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Valdes-Sosa PA; The Clinical Hospital of Chengdu Brain Sciences Institute, University of Electronic Sciences and Technology of China, Chengdu, China.; Technology of China, Chengdu, China.; Cuban Neuroscience Center, La Habana, Cuba., Lopera F; Grupo de Neurociencias de Antioquia (GNA), University of Antioquia, Medellín, Colombia., Ochoa-Gómez JF; Grupo de Neurociencias de Antioquia (GNA), University of Antioquia, Medellín, Colombia., Hernandez AG; Department of Psychology, Master Program of Clinical Neuropsychology, Universidad Surcolombiana Neiva, Neiva, Colombia., Bonilla-Santos J; Department of Psychology, Universidad Cooperativa de Colombia, Arauca, Colombia., Gonzalez-Montealegre RA; Neurocognition and Psychophysiology Laboratory, Universidad Surcolombiana, Neiva, Colombia., Anghinah R; Reference Center of Behavioural Disturbances and Dementia, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.; Traumatic Brain Injury Cognitive Rehabilitation Out-Patient Center, University of Sao Paulo, Sao Paulo, Brazil., d'Almeida Manfrinati LE; Reference Center of Behavioural Disturbances and Dementia, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.; Traumatic Brain Injury Cognitive Rehabilitation Out-Patient Center, University of Sao Paulo, Sao Paulo, Brazil., Fittipaldi S; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland., Medel V; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Olivares D; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile.; Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Program-Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, University of Chile, Santiago, Chile.; Centro de Neuropsicología Clínica (CNC), Santiago, Chile., Yener GG; Faculty of Medicine, Izmir University of Economics, Izmir, Turkey.; Brain Dynamics Multidisciplinary Research Center, Dokuz Eylul University, Izmir, Turkey.; Izmir Biomedicine and Genome Center, Izmir, Turkey., Escudero J; School of Engineering, Institute for Imaging, Data and Communications, University of Edinburgh, Edinburgh, UK., Babiloni C; Department of Physiology and Pharmacology 'V. Erspamer', Sapienza University of Rome, Rome, Italy.; Hospital San Raffaele Cassino, Cassino, Italy., Whelan R; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; School of Psychology, Trinity College Dublin, Dublin, Ireland., Güntekin B; Department of Neurosciences, Health Sciences Institute, Istanbul Medipol University, İstanbul, Turkey.; Health Sciences and Technology Research Institute (SABITA), Istanbul Medipol University, Istanbul, Turkey.; Department of Biophysics, School of Medicine, Istanbul Medipol University, Istanbul, Turkey., Yırıkoğulları H; Department of Neurosciences, Health Sciences Institute, Istanbul Medipol University, İstanbul, Turkey.; Health Sciences and Technology Research Institute (SABITA), Istanbul Medipol University, Istanbul, Turkey., Santamaria-Garcia H; Pontificia Universidad Javeriana (PhD Program in Neuroscience), Bogotá, Colombia.; Center of Memory and Cognition Intellectus, Hospital Universitario San Ignacio Bogotá, San Ignacio, Colombia., Lucas AF; Departamento de Medicina Legal, Psiquiatría y Patología, Universidad Complutense de Madrid, Madrid, Spain., Huepe D; Center for Social and Cognitive Neuroscience, School of Psychology, Universidad Adolfo Ibáñez, Santiago, Chile., Di Caterina G; Department of Electronic and Electrical Engineering, University of Strathclyde, Glasgow, UK., Soto-Añari M; Universidad Católica San Pablo, Arequipa, Peru., Birba A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Sainz-Ballesteros A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Coronel-Oliveros C; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Centro Interdisciplinario de Neurociencia de Valparaíso (CINV), Universidad de Valparaíso, Valparaíso, Chile., Yigezu A; The University of California Santa Barbara (UCSB), Santa Barbara, CA, USA., Herrera E; Departamento de Estudios Psicológicos, Universidad ICESI, Cali, Colombia., Abasolo D; Centre for Biomedical Engineering, School of Mechanical Engineering Sciences, University of Surrey, Guildford, UK., Kilborn K; School of Psychology, University of Glasgow, Glasgow, UK., Rubido N; Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen, UK., Clark RA; Centre for Signal and Image Processing, Department of Electronic and Electrical Engineering, University of Strathclyde, Strathclyde, UK., Herzog R; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile.; Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, InsermCNRS, Paris, France., Yerlikaya D; Department of Neurosciences, Health Sciences Institute, Dokuz Eylül University, Izmir, Turkey., Hu K; Harvard Medical School, Boston, MA, USA., Parra MA; Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK.; BrainLat, Universidad Adolfo Ibáñez, Santiago, Chile., Reyes P; Pontificia Universidad Javeriana (PhD Program in Neuroscience), Bogotá, Colombia.; Center of Memory and Cognition Intellectus, Hospital Universitario San Ignacio Bogotá, San Ignacio, Colombia., García AM; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Departamento de Lingüística y Literatura, Universidad de Santiago de Chile, Santiago, Chile., Matallana DL; Pontificia Universidad Javeriana (PhD Program in Neuroscience), Bogotá, Colombia.; Center of Memory and Cognition Intellectus, Hospital Universitario San Ignacio Bogotá, San Ignacio, Colombia.; Mental Health Department, Hospital Universitario Fundación Santa Fe, Bogota, Colombia., Avila-Funes JA; Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Slachevsky A; Memory and Neuropsychiatric Center (CMYN), Neurology Department, Hospital del Salvador and Faculty of Medicine, University of Chile, Santiago, Chile.; Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.; Neuropsychology and Clinical Neuroscience Laboratory (LANNEC), Physiopathology Program - Institute of Biomedical Sciences (ICBM), Neuroscience and East Neuroscience Departments, University of Chile, Santiago, Chile., Behrens MI; Neurology and Psychiatry Department, Clínica Alemana-Universidad Desarrollo, Santiago, Chile.; Centro de Investigación Clínica Avanzada (CICA), Universidad de Chile, Santiago, Chile.; Departamento de Neurología y Neurocirugía, Hospital Clínico de la Universidad de Chile, Santiago, Chile.; Departamento de Neurociencia, Universidad de Chile, Santiago, Chile., Custodio N; Servicio de Neurología, Instituto Peruano de Neurociencias, Lima, Perú., Cardona JF; Facultad de Psicología, Universidad del Valle, Cali, Colombia., Barttfeld P; Cognitive Science Group, Instituto de Investigaciones Psicológicas (IIPsi), CONICET UNC, Universidad Nacional de Córdoba, Córdoba, Argentina., Brusco IL; Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina., Bruno MA; Instituto de Ciencias Biomédicas (ICBM), Universidad Catoóica de Cuyo, San Juan, Argentina., Sosa Ortiz AL; Instituto Nacional de Neurologia y Neurocirugia MVS, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico., Pina-Escudero SD; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Takada LT; Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil., Resende E; Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Possin KL; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., de Oliveira MO; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil., Lopez-Valdes A; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; School of Engineering, Department of Electrical and Electronic Engineering, Trinity College Dublin, Dublin, Ireland.; Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.; Trinity Centre for Biomedical Engineering, Trinity College Dublin, Dublin, Ireland., Lawlor B; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland., Robertson IH; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Kosik KS; Division of the Biological Sciences, The University of Chicago, Chicago, IL, USA., Duran-Aniotz C; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile., Valcour V; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Yokoyama JS; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Miller B; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA., Ibanez A; Latin American Brain Health Institute, Universidad Adolfo Ibañez, Santiago de Chile, Chile. agustin.ibanez@gbhi.org.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina. agustin.ibanez@gbhi.org.; Global Brain Health Institute (GBHI), University of California, San Francisco, CA, USA. agustin.ibanez@gbhi.org.; Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. agustin.ibanez@gbhi.org.

Publikováno v: Nature medicine [Nat Med] 2024 Aug 26. Date of Electronic Publication: 2024 Aug 26.

Walking the talk for dementia: A unique immersive, embodied, and multi-experiential initiative.

Autor: Aguzzoli Peres F; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, USA.; Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland.; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Las Condes, Chile., Haas AN; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, USA.; Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland.; Department of Physical Education, Physiotherapy and Dance, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil., Martha AD; Atlantic Fellow for Health Equity in Southeast Asia, the Equity Initiative, Bangkok, Thailand., Chan M; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, USA.; Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland.; Institute for Research on Socio-Economic Inequality, University of Luxembourg, Esch-sur-Alzette, Luxembourg., Steele M; Atlantic Fellows for Social Equity, Australia, New Zealand and the Pacific, University of Melbourne, Melbourne, Melbourne, Austrália., Ferretti MT; Women's Brain Project, Guntershausen, Guntershausen, Switzerland., Ngcobo NN; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, USA.; Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland.; Department of Psychiatry, School of Clinical Medicine, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa., Ilinca S; World Health Organization, Regional Office for Europe, Copenhagen, Denmark., Domínguez-Vivero C; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, USA.; Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland.; Servicio Galego de Saúde, Galicia, Spain., Leroi I; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, USA.; Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland.; School of Medicine, Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland., Sajnani N; Program in Drama Therapy, Jameel Arts & Health Lab, New York University, New York, New York, USA., Zimmer ER; Graduate Program in Biological Sciences: Biochemistry (PPGBioq) and Pharmacology and Therapeutics (PPFT), Department of Pharmacology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.; The McGill University Research Centre for Studies in Aging, McGill University, Montreal, Canada.; Brain Institute of Rio Grande do Sul - Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil., Kornhuber A; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, USA.; Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland., Kalache A; International Longevity Center Brazil, Rio de Janeiro, RJ, Brazil., Holtzhausen B; Alzheimer Dementia Namibia, Windhoek, Namibia., Tristão-Pereira C; Spanish National Center for Cardiovascular Research, Madrid, Spain., Dupont C; VUB-UGhent End-of-life Care Research Group, Vrije Universiteit Brussel (VUB), Brussel, Belgium.; Department of Family Medicine and Chronic Care, Vrije Universiteit Brussel (VUB), Brussel, Belgium., Cohen D; Right to Music, New York, USA., de Jong D; DA-RE Health Innovation, Heerenveen, Friesland, Netherlands., Facal D; Departamento de Psicoloxía Evolutiva e da Educación, IDIS, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., O'Sullivan D; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Las Condes, Chile., Mateus E; Febraz - Brazilian Federation of Alzheimer's Associations, São Paulo, SP, Brasil., Roso E; Università degli Studi di Firenze, Florence, Italy., Estrop E; Voices for Hope, Dementia Singapore, Singapore, Singapore., Gamba G; Associação Crônicos do Dia a Dia (CDD), São Paulo, SP, Brasil., San Martin Elexpe G; Associação Crônicos do Dia a Dia (CDD), São Paulo, SP, Brasil., Ulises Diaz Hernández H; Federación Alzheimer Galicia, Santiago de Compostela, Spain., Quaid H; Lewy Body Ireland, Lloyd Building - Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland., Govia I; Caribbean Institute for Health Research, The University of the West Indies, Kingston 7, Jamaica., Barbosa J; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Las Condes, Chile., García Del Moral J; Confederación Española de Alzheimer (CEAFA), Pamplona, Navarra, Spain., Miller J; London School of Economics, London, UK., García García JA; Confederación Española de Alzheimer (CEAFA), Pamplona, Navarra, Spain., Quaid K; Lewy Body Ireland, Lloyd Building - Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland., Navarro L; Health Research Institute of Santiago de Compostela (IDIS), Pamplona, Spain., García LZ; Confederación Española de Alzheimer (CEAFA), Pamplona, Navarra, Spain., Waters L; Voices of Alzheimer, Chicago, Illinois, USA., Molete L; PHELA Foundation, Johannesburg, South Africa.; Tekano, Cape Town, South Africa., Godoy ME; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Las Condes, Chile., Sigauke M; Community Hope Trust, 361B/7 - Mbizo, Kwekwe, Midlands, Zimbabwe., de Ataide Schulte MW; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Las Condes, Chile., Estrop P; Voices for Hope, Dementia Singapore, Singapore, Singapore., San Martin Elexpe Cardoso P; Associação Crônicos do Dia a Dia (CDD), São Paulo, SP, Brasil., Perez R; Hospital Dr. R.A. Calderón Guardia, San José, Costa Rica., Patterson R; Dominica Dementia Foundation, Dominica, Dominica., Chakrabarti R; Trinity Business School, Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland., Wong R; Dementia Singapore, Singapore, Singapore., Marsillas S; Matia Institute of Gerontology, Madrid, Spain., Lowe S; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Las Condes, Chile., Rego TS; Federación Alzheimer Galicia, Santiago de Compostela, Spain., Farombi T; Chief Tony Anenih Geriatric Center, University College Hospital, Ibadan, Oyo, Nigeria., Montgomery T; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Las Condes, Chile., In 't Veen T; TimeSteps, The Netherlands, Europalaan 100, Utrecht, The Netherlands., Yanni V; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, USA., Weidner W; Alzheimer's Disease International, London, UK., Ibanez A; Global Brain Health Institute (GBHI), University of California San Francisco (UCSF), San Francisco, USA.; Trinity College Dublin, the University of Dublin College Green, Dublin 2, Ireland.; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibañez, Las Condes, Chile.; Cognitive Neuroscience Center (CNC), Universidad de San Andrés and CONICET Calle Vito Dumas 284, Buenos Aires, Argentina.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Mar; Vol. 20 (3), pp. 2309-2322. Date of Electronic Publication: 2024 Jan 26.

The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science.

Autor: Ibanez A; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.; School of Psychology, Center for Social and Cognitive Neuroscience, Latin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Adolfo Ibanez University, Santiago, Chile., Yokoyama JS; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.; Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States., Possin KL; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States., Matallana D; Psychiatry Department, School of Medicine, Aging Institute, Pontificia Universidad Javeriana, Bogotá, Colombia.; Memory and Cognition Clinic, Intellectus, Hospital Universitario San Ignacio, Bogotá, Colombia.; Mental Health Unit, Hospital Universitario Santa Fe de Bogotá, Bogotá, Colombia., Lopera F; Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Colombia., Nitrini R; Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil., Takada LT; Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil., Custodio N; Unit Cognitive Impairment and Dementia Prevention, Cognitive Neurology Center, Peruvian Institute of Neurosciences, Lima, Perú., Sosa Ortiz AL; Instituto Nacional de Neurologia y Neurocirugia MVS, Universidad Nacional Autonoma de Mexico, Mexico, Mexico., Avila-Funes JA; Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico.; Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France., Behrens MI; Centro de Investigación Clínica Avanzada, Hospital Clínico, Facultad de Medicina Universidad de Chile, Santiago, Chile.; Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Santiago, Chile.; Departamento de Neurociencia, Facultad de Medicina Universidad de Chile, Santiago, Chile.; Clínica Alemana Santiago, Universidad del Desarrollo, Santiago, Chile., Slachevsky A; Clínica Alemana Santiago, Universidad del Desarrollo, Santiago, Chile.; Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.; Neuropsychology and Clinical Neuroscience Laboratory, Physiopathology Department, Institute of Biomedical Sciences, Neuroscience and East Neuroscience, Santiago, Chile.; Faculty of Medicine, University of Chile, Santiago, Chile.; Memory and Neuropsychiatric Clinic (CMYN) Neurology Department, Faculty of Medicine, Hospital del Salvador, University of Chile, Santiago, Chile., Myers RM; Hudson Alpha Institute for Biotechnology, Huntsville, AL, United States., Cochran JN; Hudson Alpha Institute for Biotechnology, Huntsville, AL, United States., Brusco LI; Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.; ALZAR - Alzheimer, Buenos Aires, Argentina., Bruno MA; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.; Facultad Ciencias Médicas, Instituto Ciencias Biomédicas, Universidad Católica de Cuyo, San Juan, Argentina., Brucki SMD; Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.; Hospital Santa Marcelina, São Paulo, São Paulo, Brazil., Pina-Escudero SD; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States., Okada de Oliveira M; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Cognitive and Behavioral Neurology Unit, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil.; Hospital Santa Marcelina, São Paulo, São Paulo, Brazil., Donnelly Kehoe P; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.; Multimedia Signal Processing Group - Neuroimage Division, French-Argentine International Center for Information and Systems Sciences, Rosario, Argentina., Garcia AM; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina.; National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.; Faculty of Education, National University of Cuyo, Mendoza, Argentina., Cardona JF; Universidad del Valle, Cali, Colombia., Santamaria-Garcia H; Memory and Cognition Clinic, Intellectus, Hospital Universitario San Ignacio, Bogotá, Colombia.; Ph.D. Program in Neuroscience, Department of Psychiatry, Physiology, Pontificia Universidad Javeriana, Bogotá, Colombia., Moguilner S; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland., Duran-Aniotz C; School of Psychology, Center for Social and Cognitive Neuroscience, Latin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Adolfo Ibanez University, Santiago, Chile., Tagliazucchi E; Departamento de Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina., Maito M; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Longoria Ibarrola EM; Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico, Mexico., Pintado-Caipa M; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Unit Cognitive Impairment and Dementia Prevention, Cognitive Neurology Center, Peruvian Institute of Neurosciences, Lima, Perú., Godoy ME; Cognitive Neuroscience Center, Universidad de San Andrés, Buenos Aires, Argentina., Bakman V; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland., Javandel S; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States., Kosik KS; Department of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA, United States., Valcour V; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States., Miller BL; The Global Brain Health Institute (GBHI), University of California, San Francisco, San Francisco, CA, United States.; The Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland.; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA, United States.

Publikováno v: Frontiers in neurology [Front Neurol] 2021 Mar 11; Vol. 12, pp. 631722. Date of Electronic Publication: 2021 Mar 11 (Print Publication: 2021).