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On the mechanism of partial agonism: crystal structures of the peroxisome proliferators-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands

Autor: Pochetti G., Godio C., Loiodice F., Laghezza A., Mazza F., Crestani M., LAVECCHIA, ANTONIO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::ffc4670ed6975a103917946d659da459
http://hdl.handle.net/11588/423059

Identification of novel dual Peroxisome Proliferator-Activated Receptor alpha/gamma ligands and characterization of their biochemical properties by 3D structural studies

Autor: Godio C., Cafiero V., Mitro N., Loiodice F., Tortorella V., Pochetti G., Mazza F., Crestani M., LAVECCHIA, ANTONIO, NOVELLINO, ETTORE

The Peroxisome Proliferator-Activated Receptors (PPARs) belong to the nuclear receptor superfamily and are involved in several physiological and pathological processes. Agonists of the {alpha} and {gamma} subtypes, such as fibrates and glitazones, ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3730::e34d09a694d4a6a506f067d61a55e749
http://hdl.handle.net/11588/422968

Crystal structure of the PPAR-gamma ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design

Autor: Montanari R., Saccoccia F., Scotti E., Crestani M., Godio C., Gilardi F., Loiodice F., Fracchiolla G., Laghezza A., Tortorella P., Lavecchia A., Novellino E., Mazza F., Pochetti G.

Publikováno v: Journal of medicinal chemistry 51 (2008): 7768–7776. doi:10.1021/jm800733h
info:cnr-pdr/source/autori:Montanari R., Saccoccia F., Scotti E., Crestani M., Godio C., Gilardi F., Loiodice F., Fracchiolla G., Laghezza A., Tortorella P., Lavecchia A., Novellino E., Mazza F., Pochetti G./titolo:Crystal structure of the PPAR-gamma ligand binding domain complexed with a novel partial agonist: a new region of the hydrophobic pocket could be exploited for drug design/doi:10.1021%2Fjm800733h/rivista:Journal of medicinal chemistry/anno:2008/pagina_da:7768/pagina_a:7776/intervallo_pagine:7768–7776/volume:51

The peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors regulating glucose and lipid metabolism. The search for new PPAR ligands with reduced adverse effects with respect to the marketed antidiabetic agents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::371e412757e4af3050f54a491bc3e0c0
https://publications.cnr.it/doc/19779

Identification of novel dual peroxisome proliferator-activated receptor alpha/gamma ligands and characterization of their biochemical properties by 3D structural studies

Autor: Scotti, E., Godio, C., Pochetti, G., Mitro, N., Loiodice, F., Lavecchia, A., Novellino, E., Giuseppe FRACCHIOLLA, Tortorella, P., Laghezza, A., Mazza, F., Galmozzi, A., Caruso, D., Scurati, S., Crestani, M.

Publikováno v: ResearcherID
33rd FEBS Congress and 11th IUBMB Conference, Atene (Grecia), 2008
info:cnr-pdr/source/autori:E. Scotti, C. Godio, G. Pochetti, N. Mitro, F. Loiodice, A. Lavecchia, E. Novellino, G. Fracchiolla, P. Tortorella, A. Laghezza, F. Mazza, A. Galmozzi, D. Caruso, S. Scurati, M. Crestani./congresso_nome:33rd FEBS Congress and 11th IUBMB Conference/congresso_luogo:Atene (Grecia)/congresso_data:2008/anno:2008/pagina_da:/pagina_a:/intervallo_pagine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0d1744b762cc2e935bd6a22eb3b384bc
http://hdl.handle.net/11588/423007