Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Godfrey Rainey"'
Autor:
Bo Wang, Frances Neal, Arthur Lewis, Kapil Vashisht, Deepa S. Subramaniam, Des C. Jones, Sumati Hasani, Daniel J. Freeman, Chunning Yang, Lorraine Irving, Michael G. Overstreet, Gareth J. Browne, Suzanne I. Sitnikova, James Hair, Robert W. Wilkinson, Yaya Wang, Ben Tran, Ikbel Achour, James Dodgson, Shelby D. Gainer, Xiaofang Jin, Seock-Ah Im, William F Dall'Acqua, Yariv Mazor, Godfrey Rainey, Asis Palazon, Anna Hansen, Yanli Wu, Matthew J. Elder, Stacy Kentner, Aleksandra D. Toloczko, Michelle Morrow, Murray Thomas Vincent, Simon J. Dovedi, Kathy Mulgrew
Publikováno v:
Cancer Discovery. 11:1100-1117
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Autor:
Srinath Kasturirangan, Godfrey Rainey, Sri Hari Raju Mulagapati, Khashayar Moez, Brian Lobo, Prakash Manikwar
Publikováno v:
Journal of Pharmaceutical Sciences. 109:220-232
Bispecific antibodies containing single-chain variable fragment (scFv) appended to immunoglobulins G offer unique development challenges. Here, we describe the stability of a novel bispecific format, BiS5, where the scFv is tethered to the CH3 domain
Autor:
Roman A. Melnyk, Ramyavardhanee Chandrasekaran, D.B. Lacy, Xiaofang Jin, Zhifen Zhang, Godfrey Rainey, Andrew C. Nyborg, Ben Spiller, Heather K. Kroh, Paul Warrener, Kim Rosenthal, Robert M. Woods
Publikováno v:
Journal of Biological Chemistry. 293:941-952
Clostridium difficile infection is the leading cause of hospital-acquired diarrhea and is mediated by the actions of two toxins, TcdA and TcdB. The toxins perturb host cell function through a multistep process of receptor binding, endocytosis, low pH
Autor:
C. K. Stover, Y. Shi, Godfrey Rainey, V. Aleti, Elena Semenova, Kim Rosenthal, Omari Jones-Nelson, V. Gunter, D. Corti, David E. Tabor, Christine Tkaczyk, A. Minola, Paul Warrener, Srinath Kasturirangan, B. R. Sellman
Publikováno v:
Antimicrobial Agents and Chemotherapy
Secreted alpha-toxin and surface-localized clumping factor A (ClfA) are key virulence determinants in Staphylococcus aureus bloodstream infections. We previously demonstrated that prophylaxis with a multimechanistic monoclonal antibody (MAb) combinat
Autor:
Bo Wang, Godfrey Rainey, Ronald Herbst, Chuning Yang, Simon J. Dovedi, Michelle Morrow, Desmond Jones, Anna Hansen, James Hair, Ikbel Achour, Daniel Freeman, Gareth Browne, Yanli Wu, Yariv Mazor, Thomas G. Murray, Matthew J. Elder, Nick Durham, Robert W. Wilkinson, Suzanne Mosely, John Gooya, Sumati Hasani, Maria Jure Kunkel
Publikováno v:
Cancer Research. 78:2776-2776
Studies have demonstrated that the clinical benefit of PD-1 blockade can be further improved by combination with an αCTLA-4 mAb in some indications. However, this increased activity is commensurate with significant immune related adverse events (irA
Autor:
Antonio DiGiandomenico, Jessica Bonnell, Binyam Bezabeh, Caitlin M. Guenther, Wei Zhao, Nazzareno Dimasi, C. Kendall Stover, Godfrey Rainey, Ashley E. Keller, Vivekananda Datta, Cuihua Gao, Xiang-Qing Yu, Jamese J. Hilliard, Bret R. Sellman, Paul Warrener, JoAnn Suzich, Ryan Fleming, Mareia M. Camara, Changshou Gao
Publikováno v:
Science translational medicine. 6(262)
Widespread drug resistance due to empiric use of broad-spectrum antibiotics has stimulated development of bacteria-specific strategies for prophylaxis and therapy based on modern monoclonal antibody (mAb) technologies. However, single-mechanism mAb a