Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Godfrey Rainey"'
Autor:
Bo Wang, Frances Neal, Arthur Lewis, Kapil Vashisht, Deepa S. Subramaniam, Des C. Jones, Sumati Hasani, Daniel J. Freeman, Chunning Yang, Lorraine Irving, Michael G. Overstreet, Gareth J. Browne, Suzanne I. Sitnikova, James Hair, Robert W. Wilkinson, Yaya Wang, Ben Tran, Ikbel Achour, James Dodgson, Shelby D. Gainer, Xiaofang Jin, Seock-Ah Im, William F Dall'Acqua, Yariv Mazor, Godfrey Rainey, Asis Palazon, Anna Hansen, Yanli Wu, Matthew J. Elder, Stacy Kentner, Aleksandra D. Toloczko, Michelle Morrow, Murray Thomas Vincent, Simon J. Dovedi, Kathy Mulgrew
Publikováno v:
Cancer Discovery. 11:1100-1117
The clinical benefit of PD-1 blockade can be improved by combination with CTLA4 inhibition but is commensurate with significant immune-related adverse events suboptimally limiting the doses of anti-CTLA4 mAb that can be used. MEDI5752 is a monovalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca36b45e55f3b372d826ed6a15c12039
https://doi.org/10.1158/2159-8290.cd-20-1445
https://doi.org/10.1158/2159-8290.cd-20-1445
Autor:
Srinath Kasturirangan, Godfrey Rainey, Sri Hari Raju Mulagapati, Khashayar Moez, Brian Lobo, Prakash Manikwar
Publikováno v:
Journal of Pharmaceutical Sciences. 109:220-232
Bispecific antibodies containing single-chain variable fragment (scFv) appended to immunoglobulins G offer unique development challenges. Here, we describe the stability of a novel bispecific format, BiS5, where the scFv is tethered to the CH3 domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa760854edd1b3efdc3e4604b88de9e4
https://doi.org/10.1016/j.xphs.2019.06.025
https://doi.org/10.1016/j.xphs.2019.06.025
Autor:
Roman A. Melnyk, Ramyavardhanee Chandrasekaran, D.B. Lacy, Xiaofang Jin, Zhifen Zhang, Godfrey Rainey, Andrew C. Nyborg, Ben Spiller, Heather K. Kroh, Paul Warrener, Kim Rosenthal, Robert M. Woods
Publikováno v:
Journal of Biological Chemistry. 293:941-952
Clostridium difficile infection is the leading cause of hospital-acquired diarrhea and is mediated by the actions of two toxins, TcdA and TcdB. The toxins perturb host cell function through a multistep process of receptor binding, endocytosis, low pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf822b7b7856be7d7def3a46ef4e5a71
https://doi.org/10.1074/jbc.m117.813428
https://doi.org/10.1074/jbc.m117.813428
Autor:
Bo Wang, Godfrey Rainey, Ronald Herbst, Chuning Yang, Simon J. Dovedi, Michelle Morrow, Desmond Jones, Anna Hansen, James Hair, Ikbel Achour, Daniel Freeman, Gareth Browne, Yanli Wu, Yariv Mazor, Thomas G. Murray, Matthew J. Elder, Nick Durham, Robert W. Wilkinson, Suzanne Mosely, John Gooya, Sumati Hasani, Maria Jure Kunkel
Publikováno v:
Cancer Research. 78:2776-2776
Studies have demonstrated that the clinical benefit of PD-1 blockade can be further improved by combination with an αCTLA-4 mAb in some indications. However, this increased activity is commensurate with significant immune related adverse events (irA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2b75225fd5c252f046e28061a8a0b54
https://doi.org/10.1158/1538-7445.am2018-2776
https://doi.org/10.1158/1538-7445.am2018-2776
Autor:
C. K. Stover, Y. Shi, Godfrey Rainey, V. Aleti, Elena Semenova, Kim Rosenthal, Omari Jones-Nelson, V. Gunter, D. Corti, David E. Tabor, Christine Tkaczyk, A. Minola, Paul Warrener, Srinath Kasturirangan, B. R. Sellman
Publikováno v:
Antimicrobial Agents and Chemotherapy
Secreted alpha-toxin and surface-localized clumping factor A (ClfA) are key virulence determinants in Staphylococcus aureus bloodstream infections. We previously demonstrated that prophylaxis with a multimechanistic monoclonal antibody (MAb) combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495db4dec01ba4ea21757ffcc4149e7f
https://doi.org/10.1128/aac.00629-17
https://doi.org/10.1128/aac.00629-17
Autor:
Antonio DiGiandomenico, Jessica Bonnell, Binyam Bezabeh, Caitlin M. Guenther, Wei Zhao, Nazzareno Dimasi, C. Kendall Stover, Godfrey Rainey, Ashley E. Keller, Vivekananda Datta, Cuihua Gao, Xiang-Qing Yu, Jamese J. Hilliard, Bret R. Sellman, Paul Warrener, JoAnn Suzich, Ryan Fleming, Mareia M. Camara, Changshou Gao
Publikováno v:
Science translational medicine. 6(262)
Widespread drug resistance due to empiric use of broad-spectrum antibiotics has stimulated development of bacteria-specific strategies for prophylaxis and therapy based on modern monoclonal antibody (mAb) technologies. However, single-mechanism mAb a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b700100fcba443a63d7eead1a3fc96
https://pubmed.ncbi.nlm.nih.gov/25549587
https://pubmed.ncbi.nlm.nih.gov/25549587
Autor:
Roy, Varnika, Roth, Robert, Berge, Mark, Chitta, Rajesh, Vajrala, Sucheta, Kuntumalla, Srilatha, E. Schmelzer, Albert, Schoner, Ron
Publikováno v:
Biotechnology & Bioengineering; Aug2017, Vol. 114 Issue 8, p1753-1761, 9p
Autor:
Carmen Cauthen
The story of Raleigh's African American communities begins before the Civil War. Towns like Oberlin Village were built by free people of color in the antebellum era. During Reconstruction, the creation of thirteen freedmen's villages defined the raci
