Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Godfrey P. Smith"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/87d3145ed07c47faac6aee6c937b34e8
Autor:
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. Burton, Godfrey L. Smith, Roger Hajjar, George S. Baillie, Kenneth S. Campbell, Michael J. Shattock, William Fuller
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
S-palmitoylation is an essential lipid modification catalysed by zDHHC-palmitoyl acyltransferases that regulates the localisation and activity of substrates in every class of protein and tissue investigated to date. In the heart, S-palmitoylation reg
Externí odkaz:
https://doaj.org/article/7cbe5c5a5f744ee8954ab054d0919e50
Autor:
Godfrey P. Smith
An ascetic and failed priest, a stoic, father of the nation, prime minister and first national hero of the Central American nation of Belize, George Price remains one of the most enigmatic leaders of the 20th century. Nothing in the early years of Pr
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundThe U.S. Food and Drug Administration (FDA) has stated that citalopram and escitalopram should not be used at daily doses above 40 mg/20 mg due to risk for development of fatal ventricular arrhythmias like torsade de pointes (TdP). Yet, sup
Externí odkaz:
https://doaj.org/article/8915ea02f5c54004873fb050046fd6c1
Autor:
M. Caroline Müllenbroich, Allen Kelly, Corey Acker, Gil Bub, Tobias Bruegmann, Anna Di Bona, Emilia Entcheva, Cecilia Ferrantini, Peter Kohl, Stephan E. Lehnart, Marco Mongillo, Camilla Parmeggiani, Claudia Richter, Philipp Sasse, Tania Zaglia, Leonardo Sacconi, Godfrey L. Smith
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Optical techniques for recording and manipulating cellular electrophysiology have advanced rapidly in just a few decades. These developments allow for the analysis of cardiac cellular dynamics at multiple scales while largely overcoming the drawbacks
Externí odkaz:
https://doaj.org/article/a9e4c73a9f3a472da2cc8abc80c6b389
Autor:
Richard J. Jabbour, Thomas J. Owen, Pragati Pandey, Marina Reinsch, Brian Wang, Oisín King, Liam Steven Couch, Dafni Pantou, David S. Pitcher, Rasheda A. Chowdhury, Fotios G. Pitoulis, Balvinder S. Handa, Worrapong Kit-Anan, Filippo Perbellini, Rachel C. Myles, Daniel J. Stuckey, Michael Dunne, Mayooran Shanmuganathan, Nicholas S. Peters, Fu Siong Ng, Florian Weinberger, Cesare M. Terracciano, Godfrey L. Smith, Thomas Eschenhagen, Sian E. Harding
Publikováno v:
JCI Insight, Vol 6, Iss 15 (2021)
Engineered heart tissue (EHT) strategies, by combining cells within a hydrogel matrix, may be a novel therapy for heart failure. EHTs restore cardiac function in rodent injury models, but more data are needed in clinically relevant settings. Accordin
Externí odkaz:
https://doaj.org/article/5f7e39207cc8495596ab20ad1eee6e60
Publikováno v:
PeerJ, Vol 9, p e11485 (2021)
The global incidence, associated mortality rates and economic burden of diabetes are now such that it is considered one of the most pressing worldwide public health challenges. Considerable research is now devoted to better understanding the mechanis
Externí odkaz:
https://doaj.org/article/369df6e028144ccc8c2b20eeafb9b3ee
Publikováno v:
Heliyon, Vol 6, Iss 1, Pp e03031- (2020)
Connexin 43 expression (Cx43) is increased in cardiac fibroblasts (CFs) following myocardial infarction. Here, potential mediators responsible for increasing Cx43 expression and effects of differential CF phenotype on cardiac myocyte (CM) function we
Externí odkaz:
https://doaj.org/article/64f7caaa08ab4692b43684b3a4a8f39b
Autor:
Alan Faulkner-Jones, Victor Zamora, Maria P. Hortigon-Vinagre, Wenxing Wang, Marcus Ardron, Godfrey L. Smith, Wenmiao Shu
Publikováno v:
Bioengineering, Vol 9, Iss 1, p 32 (2022)
In this work, we show that valve-based bioprinting induces no measurable detrimental effects on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The aim of the current study was three-fold: first, to assess the response of hiPS
Externí odkaz:
https://doaj.org/article/3e2f6f9b2b834ab0a52ff27d97bd35af
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
SNARE proteins are integral to intracellular vesicular trafficking, which in turn is the process underlying the regulated expression of substrate transporters such as the glucose transporter GLUT4 at the cell surface of insulin target tissues. Impair
Externí odkaz:
https://doaj.org/article/696e69688cc944e3a8ce8de00e073e45