Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Godfrey Grech"'
Autor:
Jeanesse Scerri, Christian Scerri, Felix Schäfer-Ruoff, Simon Fink, Markus Templin, Godfrey Grech
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Protein expression, activation and stability are regulated through inter-connected signal transduction pathways resulting in specific cellular states. This study sought to differentiate between the complex mechanisms of intrinsic and acquired trastuz
Externí odkaz:
https://doaj.org/article/88bc182dd81e471287768db22eecb0fc
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1738 (2023)
Over the years, increasing evidence has shown that copy number variations (CNVs) play an important role in the pathogenesis and prognosis of Colorectal Cancer (CRC). Colorectal adenomas are highly prevalent lesions, but only 5% of these adenomas ever
Externí odkaz:
https://doaj.org/article/5e5f5402380944d0ae2eefdb19a2f4b9
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 21, p 4999 (2021)
Protein phosphatase 2A (PP2A) is a ubiquitously expressed intracellular serine/threonine phosphatase. Deregulation of PP2A is a common event associated with adenocarcinomas of the colon and rectum. We have previously shown that breast cancer cell lin
Externí odkaz:
https://doaj.org/article/fe5a853e96744e33b7f82aa26ef28cdc
Autor:
Shawn Baldacchino, Laura M Wastall, Christian Saliba, Thomas A Hughes, Christian Scerri, Angelene Berwick, Valerie Speirs, Andrew M Hanby, Godfrey Grech
Publikováno v:
Tumor Biology, Vol 39 (2017)
CIP2A is emerging as an oncoprotein overexpressed commonly across many tumours and generally correlated with higher tumour grade and therapeutic resistance. CIP2A drives an oncogenic potential through inhibiting protein phosphatase 2A, stabilizing MY
Externí odkaz:
https://doaj.org/article/d72e184faeaa4b3fa5a411820ccf90f4
Autor:
Clint Mizzi, Eleni Dalabira, Judit Kumuthini, Nduna Dzimiri, Istvan Balogh, Nazli Başak, Ruwen Böhm, Joseph Borg, Paola Borgiani, Nada Bozina, Henrike Bruckmueller, Beata Burzynska, Angel Carracedo, Ingolf Cascorbi, Constantinos Deltas, Vita Dolzan, Anthony Fenech, Godfrey Grech, Vytautas Kasiulevicius, Ľudevít Kádaši, Vaidutis Kučinskas, Elza Khusnutdinova, Yiannis L Loukas, Milan Macek, Halyna Makukh, Ron Mathijssen, Konstantinos Mitropoulos, Christina Mitropoulou, Giuseppe Novelli, Ioanna Papantoni, Sonja Pavlovic, Giuseppe Saglio, Jadranka Sertić, Maja Stojiljkovic, Andrew P Stubbs, Alessio Squassina, Maria Torres, Marek Turnovec, Ron H van Schaik, Konstantinos Voskarides, Salma M Wakil, Anneke Werk, Maria Del Zompo, Branka Zukic, Theodora Katsila, Ming Ta Michael Lee, Alison Motsinger-Rief, Howard L Mc Leod, Peter J van der Spek, George P Patrinos
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172595 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0162866.].
Externí odkaz:
https://doaj.org/article/bfb926067d6344b3b90c530f5e7e1bb4
Autor:
Clint Mizzi, Eleni Dalabira, Judit Kumuthini, Nduna Dzimiri, Istvan Balogh, Nazli Başak, Ruwen Böhm, Joseph Borg, Paola Borgiani, Nada Bozina, Henrike Bruckmueller, Beata Burzynska, Angel Carracedo, Ingolf Cascorbi, Constantinos Deltas, Vita Dolzan, Anthony Fenech, Godfrey Grech, Vytautas Kasiulevicius, Ľudevít Kádaši, Vaidutis Kučinskas, Elza Khusnutdinova, Yiannis L Loukas, Milan Macek, Halyna Makukh, Ron Mathijssen, Konstantinos Mitropoulos, Christina Mitropoulou, Giuseppe Novelli, Ioanna Papantoni, Sonja Pavlovic, Giuseppe Saglio, Jadranka Setric, Maja Stojiljkovic, Andrew P Stubbs, Alessio Squassina, Maria Torres, Marek Turnovec, Ron H van Schaik, Konstantinos Voskarides, Salma M Wakil, Anneke Werk, Maria Del Zompo, Branka Zukic, Theodora Katsila, Ming Ta Michael Lee, Alison Motsinger-Rief, Howard L Mc Leod, Peter J van der Spek, George P Patrinos
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162866 (2016)
Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In sev
Externí odkaz:
https://doaj.org/article/65d317caa72545be89067d0f39dc3afe
Autor:
Andrzej Nieradka, Christoph Ufer, Klaske Thiadens, Godfrey Grech, Rastislav Horos, Marleen van Coevorden-Hameete, Emile van den Akker, Sajad Sofi, Hartmut Kuhn, Marieke von Lindern
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e104631 (2014)
Induction of cell proliferation requires a concomitant increase in the synthesis of glycosylated lipids and membrane proteins, which is dependent on ER-Golgi protein transport by CopII-coated vesicles. In this process, retrograde transport of ER resi
Externí odkaz:
https://doaj.org/article/3b431108fb39437887ed8ca40df5c934
Autor:
Stephen C Sciberras, Adrian P Vella, Bernice Vella, Jessica Spiteri, Christabel Mizzi, Keith Borg-Xuereb, Godfrey LaFerla, Godfrey Grech, Fiona Sammut
Publikováno v:
Pain Management. 12:711-723
Aim: The study sought to evaluate the influence of anesthesia on chronic pain after total knee arthroplasty (TKA). Methods: This was a single-center, randomized controlled study, with patients receiving a spinal anesthetic (SP) alone or a general ane
Publikováno v:
Rheumatology. 61
Background/Aims A number of studies have demonstrated the inverse association between vitamin D and (i) disease activity and (ii) interferon (IFN) signature gene expression in systemic lupus erythematosus (SLE). The aim of the study was to establish
Autor:
Giovanni Tesoriere, Shawn Baldacchino, Anna De Blasio, Renza Vento, Riccardo Di Fiore, Giovanni Pratelli, Christian Scerri, Godfrey Grech, Rosa Drago-Ferrante, Christian Saliba
Publikováno v:
Journal of Cellular Physiology. 235:629-637
The present study shows that nuclear factor erythroid 2-related factor 2 (NRF2) and miR-29b-1-5p are two opposite forces which could regulate the fate of MDA-MB-231 cells, the most studied triple-negative breast cancer (TNBC) cell line. We show that