Výsledky vyhledávání - "Godfrey Dzhivhuho"

Akademický článek

HIV-1 Rev-RRE functional activity in primary isolates is highly dependent on minimal context-dependent changes in Rev

Autor: Godfrey Dzhivhuho, Jordan Holsey, Ethan Honeycutt, Heather O’Farrell, David Rekosh, Marie-Louise Hammarskjold, Patrick E. H. Jackson

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract During HIV infection, intron-containing viral mRNAs are exported from the cell nucleus to the cytoplasm to complete the replication cycle. Cellular restrictions on the export of incompletely spliced transcripts are overcome by a viral protei

Externí odkaz: https://doaj.org/article/f9ea2afbd3384aefb96331fd4a330b11

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Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis

Autor: Patrick E. H. Jackson, Godfrey Dzhivhuho, Marie-Louise Hammarskjold, David Rekosh

Publikováno v: Curr HIV Res

Background: To complete its replication cycle, HIV-1 requires the nucleocytoplasmic export of intron-containing viral mRNAs. This process is ordinarily restricted by the cell, but HIV overcomes the block by means of a viral protein, Rev, and an RNA s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004fbb765c703f51fcf1c8ee7775ac17
https://doi.org/10.2174/1570162x18666200106112842

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Genetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke

Autor: Michèle M. Sale, Andrew M. Southerland, Stephen R. Williams, Karen L. Furie, Godfrey Dzhivhuho, Bradford B. Worrall, Fang-Chi Hsu, Wei-Min Chen, Stephen S. Rich, Keith L. Keene, Joe L. Rowles

Publikováno v: Stroke. 48:1444-1450

Background and Purpose— von Willebrand factor (vWF) plays an important role in thrombus formation during cerebrovascular damage. We sought to investigate the potential role of circulating vWF in recurrent cerebrovascular events and identify genetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3236e699a3b194800351656dad386ee
https://doi.org/10.1161/strokeaha.116.015677

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Winter Is Coming: A Southern Hemisphere Perspective of the Environmental Drivers of SARS-CoV-2 and the Potential Seasonality of COVID-19

Autor: Robert J. Scholes, Godfrey Dzhivhuho, Neville Sweijd, Jennifer M. Fitchett, Albertus J. Smit, Francois Engelbrecht

Publikováno v: International Journal of Environmental Research and Public Health, Vol 17, Iss 5634, p 5634 (2020)
International Journal of Environmental Research and Public Health

SARS-CoV-2 virus infections in humans were first reported in December 2019, the boreal winter. The resulting COVID-19 pandemic was declared by the WHO in March 2020. By July 2020 COVID-19 is present in 213 countries and territories, with over 12 mill

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01535c14a56b18ae3c5ae65b355f1ad1
https://doi.org/10.3390/ijerph17165634

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Chronic schistosomiasis suppresses HIV-specific responses to DNA-MVA and MVA-gp140 Env vaccine regimens despite antihelminthic treatment and increases helminth-associated pathology in a mouse model

Autor: Gerald K. Chege, Samantha A. Rehrl, Hlumani Ndlovu, William G. C. Horsnell, Anna-Lise Williamson, Frank Brombacher, Godfrey Dzhivhuho

Publikováno v: PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2018, 14 (7), pp.e1007182. ⟨10.1371/journal.ppat.1007182⟩
PLOS Pathogens
PLoS Pathogens, Vol 14, Iss 7, p e1007182 (2018)

Future HIV vaccines are expected to induce effective Th1 cell-mediated and Env-specific antibody responses that are necessary to offer protective immunity to HIV infection. However, HIV infections are highly prevalent in helminth endemic areas. Helmi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11ba8469cb0589de6b21d76b0669912
https://hal.archives-ouvertes.fr/hal-02506233/document

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Association of interleukin-8 gene polymorphisms in HIV patients with opportunistic infections in Limpopo Province, South Africa

Autor: T.C. Nangammbi, A. Samie, Godfrey Dzhivhuho

Publikováno v: Genetics and Molecular Research. 15

Opportunistic infections (OIs) are common among human immunodeficiency virus (HIV) patients; however, genetic susceptibility to these infections has not been studied. Recent studies have shown that interleukin-8 (IL-8) A/T genotype carriers are more

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e990834aa91b7d3de445ccb72c9fbeb
https://doi.org/10.4238/gmr.15017466

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Shared genetic susceptibility of vascular-related biomarkers with ischemic and recurrent stroke

Objective: To investigate the genetic contributors to cerebrovascular disease and variation in biomarkers of ischemic stroke. Methods: The Vitamin Intervention for Stroke Prevention Trial (VISP) was a randomized, controlled clinical trial of B vitami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745953bea4774d61f6d3a4842718a5da
https://hdl.handle.net/10453/156261

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Distribution of CXCR2 +1208 T/C gene polymorphisms in relation to opportunistic infections among HIV-infected patients in Limpopo Province, South Africa

Autor: A. Samie, Godfrey Dzhivhuho, T.C. Nangammbi

Publikováno v: Genetics and molecular research : GMR. 13(3)

Interleukin 8 (IL-8) is a chemokine produced by macrophages and other cell types, including epithelial cells, and its receptor is CXCR2. IL-8 plays an important role in the initiation and amplification of inflammatory diseases, including opportunisti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41eb6622cdebf37930643a87c63f36ea
https://pubmed.ncbi.nlm.nih.gov/25222246

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