Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Godfrey Andrew Aydon"'
Autor:
John M. Woodley, Ravendra Singh, Godfrey Andrew Aydon, Björn Gregertsen, Krist V. Gernaey, Frans L. Muller, Rafiqul Gani
Publikováno v:
Computers & Chemical Engineering
The discovery of an effective and safe pharmaceutical product is based on success in clinical trials. Often, several candidate compounds targeting the same disease area are tested in order to identify the most efficacious products. This involves the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf149c221e06e9d77150c9f48735bf13
https://doi.org/10.1016/j.compchemeng.2013.07.010
https://doi.org/10.1016/j.compchemeng.2013.07.010
Publikováno v:
Tetrahedron Letters. 52:2024-2027
The facile synthesis of a range of novel isoquinuclidinones from 6-acyl-cyclohex-2-enones is described, employing aqueous ammonia in a one-pot procedure involving initial conjugate addition of ammonia followed by cyclisation via intramolecular imine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f995e856a34dc34463c15fb7432c4e7c
https://doi.org/10.1016/j.tetlet.2010.08.052
https://doi.org/10.1016/j.tetlet.2010.08.052
Autor:
Jeffrey J Barlow, Lynn Scarlett, Keith Hopkinson Gibson, Susan Ashton, Walter Grundy, Lianne Henthorn, Laura Richards, Brenda Curry, Mark P Healy, Barker Andrew John, J. R. Woodburn, Godfrey Andrew Aydon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1911-1914
This paper describes the development of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 from a lead series of 4-anilinoquinazoline compounds. ZD1839 has suitable properties for use as a clinically effective drug and shows activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5e7f9677dcaece0be49d1d7955bb92
https://doi.org/10.1016/s0960-894x(01)00344-4
https://doi.org/10.1016/s0960-894x(01)00344-4
Autor:
L. Scarlett, Walter Grundy, Barker Andrew John, Keith Hopkinson Gibson, J. R. Woodburn, Susan Ashton, Godfrey Andrew Aydon, D. S. Brown, Brenda Curry
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2723-2728
Investigation of structure-activity relationships of novel quinazolines has identified a 4-(4-iso-quinolylamino)-quinazoline and a 4-(trans-2-phenylcyclopropylamino)-quinazoline as potent inhibitors of EGF-receptor tyrosine kinase in vitro. Further m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f26719b22c3fb3d845020a451d1ee1db
https://doi.org/10.1016/s0960-894x(97)10059-2
https://doi.org/10.1016/s0960-894x(97)10059-2
Autor:
Bolin Geng, Joseph V. Newman, David E. Ehmann, John Breen, Patrick J. Brassil, Paul J. Ciaccio, Janelle Comita-Prevoir, Kosalaram Goteti, Herbert Barthlow, Mark T. D. Cronin, John McNulty, Stewart L. Fisher, Folkert Reck, Godfrey Andrew Aydon, Richard A. Alm
Publikováno v:
Journal of medicinal chemistry. 55(15)
Novel non-fluoroquinolone inhibitors of bacterial type II topoisomerases (DNA gyrase and topoisomerase IV) are of interest for the development of new antibacterial agents that are not impacted by target-mediated cross-resistance with fluoroquinolones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c0871ce6e6d22d0012777d5f9ea2a5
https://pubmed.ncbi.nlm.nih.gov/22779424
https://pubmed.ncbi.nlm.nih.gov/22779424
Publikováno v:
ChemInform. 43
A variety of partially reduced heterocycles is easily prepared by cyclization of alkynyl acetals in formic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38397239dd000ed201d277ce64b870c5
https://doi.org/10.1002/chin.201222027
https://doi.org/10.1002/chin.201222027
Publikováno v:
ChemInform. 42
The sequence converts 6-acyl-cyclohex-2-enones of type (I) directly to the required isoquinuclidinones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b900f99b3b16a23097c8212cd595d0c9
https://doi.org/10.1002/chin.201130166
https://doi.org/10.1002/chin.201130166
Publikováno v:
ChemInform. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a99775fc669725278445104648dbad71
https://doi.org/10.1002/chin.201111174
https://doi.org/10.1002/chin.201111174
Autor:
Godfrey Andrew Aydon, Susan Ashton, J. R. Woodburn, Walter Grundy, L. Scarlett, Barker Andrew John, Brenda Curry, Keith Hopkinson Gibson, D. S. Brown
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::563f95e1f8a277c298ede2212b65342d
https://doi.org/10.1002/chin.199808235
https://doi.org/10.1002/chin.199808235
Publikováno v:
HETEROCYCLES. 84:1013
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c45a0945946dfaefa3e4e8b2336793e5
https://doi.org/10.3987/com-11-s(p)79
https://doi.org/10.3987/com-11-s(p)79