Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Godefroid Charbon"'
Publikováno v:
Frontiers in Antibiotics, Vol 3 (2024)
Initiation of chromosome replication is an essential stage of the bacterial cell cycle that is controlled by the DnaA protein. With the aim of developing novel antimicrobials, we have targeted the initiation of DNA replication, using antisense peptid
Externí odkaz:
https://doaj.org/article/46cfcb5c2169412192f7ce3dbbfb8fc4
Autor:
Jakob Frimodt-Møller, Andreas Koulouktsis, Godefroid Charbon, Marit Otterlei, Peter E. Nielsen, Anders Løbner-Olesen
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 444-454 (2021)
Cell-penetrating peptides (CPPs) are increasingly used for cellular drug delivery in both pro- and eukaryotic cells, and oligoarginines have attracted special attention. How arginine-rich CPPs translocate across the cell envelope, particularly for pr
Externí odkaz:
https://doaj.org/article/253da9a6a4314fa899fff9d789465764
Autor:
Karoline Knudsen List, Mette Kolpen, Kasper Nørskov Kragh, Godefroid Charbon, Stine Radmer, Frank Hansen, Anders Løbner-Olesen, Niels Frimodt-Møller, Frederik Boetius Hertz
Publikováno v:
Antibiotics, Vol 11, Iss 10, p 1280 (2022)
Background: Carbapenemase-producing Klebsiella pneumoniae and Escherichia coli have become a significant global health challenge. This has created an urgent need for new treatment modalities. We evaluated the efficacy of mecillinam in combination wit
Externí odkaz:
https://doaj.org/article/56a8085ec6754a66be2da7c17c428d8b
Autor:
Godefroid Charbon, Belén Mendoza-Chamizo, Christopher Campion, Xiaobo Li, Peter Ruhdal Jensen, Jakob Frimodt-Møller, Anders Løbner-Olesen
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
During steady-state Escherichia coli growth, the amount and activity of the initiator protein, DnaA, controls chromosome replication tightly so that initiation only takes place once per origin in each cell cycle, regardless of growth conditions. Howe
Externí odkaz:
https://doaj.org/article/70ee0877be7a4be4956bbcc5a4732c01
Publikováno v:
Antibiotics, Vol 9, Iss 5, p 239 (2020)
For the past several decades, the success of bacterial strains in infecting their host has been essentially ascribed to the presence of canonical virulence genes. While it is unclear how much growth rate impacts the outcome of an infection, it is lon
Externí odkaz:
https://doaj.org/article/9c838dddf16542d28b6ae50c9faa7d13
Autor:
Godefroid Charbon, Christopher Campion, Siu Hung Joshua Chan, Louise Bjørn, Allan Weimann, Luís Cláudio Nascimento da Silva, Peter Ruhdal Jensen, Anders Løbner-Olesen
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006590 (2017)
Chromosome replication in Escherichia coli is initiated by DnaA. DnaA binds ATP which is essential for formation of a DnaA-oriC nucleoprotein complex that promotes strand opening, helicase loading and replisome assembly. Following initiation, DnaAATP
Externí odkaz:
https://doaj.org/article/b0af3936219241299254d82ae0f013e3
Autor:
Maria Schei Haugan, Frederik Boëtius Hertz, Godefroid Charbon, Berivan Sahin, Anders Løbner-Olesen, Niels Frimodt-Møller
Publikováno v:
Antibiotics, Vol 8, Iss 3, p 92 (2019)
Escherichia coli is the primary cause of urinary tract infection (UTI), which is one of the most frequent human infections. While much is understood about the virulence factors utilized by uropathogenic E. coli (UPEC), less is known about the bacteri
Externí odkaz:
https://doaj.org/article/56d7942297aa42f39bed57fb133e547e
Publikováno v:
Genes, Vol 9, Iss 11, p 565 (2018)
The facultative aerobic bacterium Escherichia coli adjusts its cell cycle to environmental conditions. Because of its lifestyle, the bacterium has to balance the use of oxygen with the potential lethal effects of its poisonous derivatives. Oxidative
Externí odkaz:
https://doaj.org/article/5876c11a22b04d649e370b6f53ea836e
Publikováno v:
PLoS Genetics, Vol 12, Iss 9, p e1006286 (2016)
Chromosome replication in Escherichia coli is in part controlled by three non-coding genomic sequences, DARS1, DARS2, and datA that modulate the activity of the initiator protein DnaA. The relative distance from oriC to the non-coding regions are con
Externí odkaz:
https://doaj.org/article/809e5878eeed464ba4fddc184cfe9a5a
Autor:
Wilhelm Paulander, Ying Wang, Anders Folkesson, Godefroid Charbon, Anders Løbner-Olesen, Hanne Ingmer
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92231 (2014)
It was recently proposed that for bactericidal antibiotics a common killing mechanism contributes to lethality involving indirect stimulation of hydroxyl radical (OH•) formation. Flow cytometric detection of OH• by hydroxyphenyl fluorescein (HPF)
Externí odkaz:
https://doaj.org/article/bca036ec0fe8432c8be5dfa52bc1ad88