Systems Biology of Stress in Bacillus Megaterium and Its Potential Applications

Autor: Godard, Thibault, Krull, Rainer

Generally, once a producer has been genetically designed, optimal process parameters are established to maximise its potential for industrial production. Despite this upstream work, bacterial cells are constantly exposed to various kinds of stress du

Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in Brucella

Autor: Barbier, Thibault, Collard, François, Zúñiga-Ripa, Amaia, Moriyón, Ignacio, Godard, Thibault, Becker, Judith, Wittmann, Christoph, Van Schaftingen, Emile, Letesson, Jean-Jacques

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2014 Dec . 111(50), 17815-17820.

Externí odkaz: https://www.jstor.org/stable/43278791

Metabolic Rearrangements Causing Elevated Proline and Polyhydroxybutyrate Accumulation During the Osmotic Adaptation Response of Bacillus megaterium

Autor: Godard, Thibault, Zühlke, Daniela, Richter, Georg, Wall, Melanie, Rohde, Manfred, Riedel, Katharina, Poblete Castro, Ignacio Andrés, Krull, Rainer, Biedendieck, Rebekka Katrin Johanna

Publikováno v: Frontiers in Bioengineering and Biotechnology
Frontiers in Bioengineering and Biotechnology., 21 February 2020, https://doi.org/10.3389/fbioe.2020.00047--http://www.frontiersin.org/Bioengineering_and_Biotechnology/about--http://www.bibliothek.uni-regensburg.de/ezeit/?2719493--2296-4185

For many years now, Bacillus megaterium serves as a microbial workhorse for the high-level production of recombinant proteins in the g/L-scale. However, efficient and stable production processes require the knowledge of the molecular adaptation strat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e530a1fd751dfba9914dd640fa15d058
http://europepmc.org/articles/PMC7053513

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Micro- and Macroparticle Enhanced Cultivation of Filamentous Lentzea Aerocolonigenes for Increased Rebeccamycin Production

Autor: Schrinner, Kathrin

The filamentous actinomycete Lentzea aerocolonigenes produces the antitumor antibiotic rebeccamycin. However, the complex morphology of actinomycetes leads to challenges during the cultivation often accompanied by low product titers. In the recent pa