Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Goar Smbatyan"'
Autor:
Nikhil Baban Ghate, Sangnam Kim, Erin Spiller, Sungmin Kim, Yonghwan Shin, Suhn K. Rhie, Goar Smbatyan, Heinz‐Josef Lenz, Shannon M. Mumenthaler, Woojin An
Publikováno v:
Molecular Oncology, Vol 15, Iss 10, Pp 2801-2817 (2021)
Histone modification is aberrantly regulated in cancer and generates an unbalanced state of gene transcription. VprBP, a recently identified kinase, phosphorylates histone H2A on threonine 120 (T120) and is involved in oncogenic transcriptional dysre
Externí odkaz:
https://doaj.org/article/f42243ee3a4b4696944f5c145e434f9c
Autor:
Yi Zhao, Kaijin Wu, Cu Nguyen, Goar Smbatyan, Elisabeth Melendez, Yusuke Higuchi, Yibu Chen, Michael Kahn
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177245 (2017)
There is currently no FDA approved therapeutic agent for ARS mitigation post radiation exposure. Here we report that the small molecule YH250, which specifically antagonizes p300/catenin interaction, stimulates hematopoiesis in lethally or sublethall
Externí odkaz:
https://doaj.org/article/0c836b93e6c44cbeb1d412dbcec4d3f8
Autor:
Michael Rosol, Ira Harutyunyan, JingYing Xu, Elizabeth Melendez, Goar Smbatyan, Jonathan L. Finlay, Mark D. Krieger, Ignacio Gonzalez-Gomez, C. Patrick Reynolds, Marvin D. Nelson, Anat Erdreich-Epstein, Stefan Blüml
Publikováno v:
Molecular Imaging, Vol 8 (2009)
We used magnetic resonance spectroscopy to determine whether orthotopic mouse brain tumors grown as xenografts in immunocompromised mice either from human brain tumor cells implanted immediately after surgery or from cultured human tumor lines show m
Externí odkaz:
https://doaj.org/article/5874efc3d1564806a3a501db85c56fce
Autor:
Sungmin Kim, Nikhil Baban Ghate, Sang Nam Kim, Suhn K. Rhie, Goar Smbatyan, Woojin An, Shannon M. Mumenthaler, Yonghwan Shin, Erin Spiller, Heinz-Josef Lenz
Publikováno v:
Molecular Oncology, Vol 15, Iss 10, Pp 2801-2817 (2021)
Molecular Oncology
Molecular Oncology
Histone modification is aberrantly regulated in cancer and generates an unbalanced state of gene transcription. VprBP, a recently identified kinase, phosphorylates histone H2A on threonine 120 (T120) and is involved in oncogenic transcriptional dysre
Autor:
Jiawei Li, Fan Fei, Qinqin Cheng, Jianming Xie, Stan G. Louie, Hua Pei, Junji Watanabe, Yong Zhang, Alireza Abdolvahabi, Zhefu Dai, Tianling Hou, Xiao-Nan Zhang, Goar Smbatyan, Heinz-Josef Lenz
Publikováno v:
Journal of Controlled Release. 336:433-442
Random conjugations of chemotherapeutics to monoclonal antibodies result in heterogeneous antibody-drug conjugates (ADCs) with suboptimal pharmacological properties. We recently developed a new technology for facile generation of homogeneous ADCs by
Autor:
Shivani Soni, Francesca Battaglin, Sofi Castanon, Jae Ho Lo, Goar Smbatyan, Priscilla Chan, Meng Qu, Priya Jayachandran, Hiroyuki Arai, Natsuko Kawanishi, Wu Zhang, Steve A. Kay, Heinz Josef Lenz, Evanthia T. Torres
Publikováno v:
Cancer Research. 83:4124-4124
Background. Immune checkpoint inhibitors have substantial clinical success in MSI-H/dMMR metastatic CRC. However, only a subset of patients exhibits durable responses, emphasizing the importance of identifying mechanism of innate and acquired resista
Autor:
Qinqin Cheng, Yong Zhang, Alan L. Epstein, Goar Smbatyan, Tianling Hou, Heinz-Josef Lenz, Julie E. Lang, Menglu Han, Xiaojing Shi
Publikováno v:
Mol Ther
Exosomes are nanosized membranous vesicles secreted by a variety of cells. Due to their unique and pharmacologically important properties, cell-derived exosome nanoparticles have drawn significant interest for drug development. By genetically modifyi
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 30, iss 9
Exosomes are cell-derived nanovesicles involved in regulating intercellular communications. In contrast to conventional nanomedicines, exosomes are characterized by unique advantages for therapeutic development. Despite their major successes in drug
Autor:
Sungmin Kim, Erin Spiller, Heinz-Josef Lenz, Nikhil Baban Ghate, Sang Nam Kim, Goar Smbatyan, Woojin An, Yonghwan Shin, Shannon M. Mumenthaler, Suhn K. Rhie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff6587b7609b36adef7b4d921d6fedc
https://doi.org/10.1002/1878-0261.13068/v3/response1
https://doi.org/10.1002/1878-0261.13068/v3/response1
Autor:
Robin L. Owen, Joanne E. Nettleship, Thomas Simon, Angeliki Ditsiou, Shivani Soni, Laurence H. Pearl, Chrisostomos Prodromou, Athanasios Papakyriakou, John Spencer, Maria Chiara Iachini, Lihong Zhou, Leanne Milton-Harris, Teresa Gagliano, Jae Ho Lo, Goar Smbatyan, Heinz-Josef Lenz, Sahir Khurshid, Storm Hassell-Hart, Philip Carter, Raymond J. Owens, Naomi E. Chayen, Georgios Giamas, Viviana Vella, Apostolos Klinakis, Panagiota Ntavelou, S. Mark Roe, Justin Stebbing, Chiara Cilibrasi, Nikiana Simigdala
Publikováno v:
Science Advances
The structure of oncogenic LMTK3 determines its role and functions allowing drug inhibition as a new therapeutic strategy.
Elucidating signaling driven by lemur tyrosine kinase 3 (LMTK3) could help drug development. Here, we solve the crystal st
Elucidating signaling driven by lemur tyrosine kinase 3 (LMTK3) could help drug development. Here, we solve the crystal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218bf1104e6c0496d79e2bad312b2532
http://hdl.handle.net/10044/1/84171
http://hdl.handle.net/10044/1/84171