Dietary fiber guar gum-induced shift in gut microbiota metabolism and intestinal immune activity enhances susceptibility to colonic inflammation.

Autor: Paudel D; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Nair DVT; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Tian S; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Hao F; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA., Goand UK; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Joseph G; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Prodes E; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA., Chai Z; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Robert CEM; INSERM U1016, team 'Mucosal microbiota in chronic inflammatory diseases', CNRS UMR 8104, Université Paris Cité, Paris, France.; INSERM U1306, Microbiome-Host Interaction group, Institut Pasteur, Université Paris Cité, Paris, France., Chassaing B; INSERM U1016, team 'Mucosal microbiota in chronic inflammatory diseases', CNRS UMR 8104, Université Paris Cité, Paris, France.; INSERM U1306, Microbiome-Host Interaction group, Institut Pasteur, Université Paris Cité, Paris, France., Patterson AD; Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA., Singh V; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA.

Publikováno v: Gut microbes [Gut Microbes] 2024 Jan-Dec; Vol. 16 (1), pp. 2341457. Date of Electronic Publication: 2024 Apr 17.

Pancreastatin inhibitor PSTi8 ameliorates insulin resistance by decreasing fat accumulation and oxidative stress in high-fat diet-fed mice.

Autor: Garg R; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Agarwal A; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Katekar R; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Goand UK; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Singh N; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India., Yadav S; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Rathaur S; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India., Verma S; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Maity D; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India., Vishwakarma S; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India., Gayen JR; Pharmaceutics and Pharmacokinetics, Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India. jr.gayen@cdri.res.in.; Pharmacology Division, CSIR-Central Drug Research Institute, Sector-10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, India. jr.gayen@cdri.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. jr.gayen@cdri.res.in.

Publikováno v: Amino acids [Amino Acids] 2023 Nov; Vol. 55 (11), pp. 1587-1600. Date of Electronic Publication: 2023 Sep 16.

Pancreastatin inhibitor PSTi8 ameliorates streptozotocin-induced diabetes by suppressing hepatic glucose production.

Autor: Garg R; Pharmaceutics & Pharmacokinetics, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Katekar R; Pharmaceutics & Pharmacokinetics, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Parwez S; Biochemistry and Structural Biology, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Agarwal A; Pharmaceutics & Pharmacokinetics, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Sahu S; Pharmaceutics & Pharmacokinetics, India., Dadge S; Pharmaceutics & Pharmacokinetics, India., Verma S; Pharmaceutics & Pharmacokinetics, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Goand UK; Pharmaceutics & Pharmacokinetics, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Siddiqi MI; Biochemistry and Structural Biology, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow, 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Gayen JR; Pharmaceutics & Pharmacokinetics, India; Pharmacology Division, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address: jr.gayen@cdri.res.in.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2023 Apr 05; Vol. 944, pp. 175559. Date of Electronic Publication: 2023 Feb 09.

Pancreastatin inhibitor PSTi8 balances energy homeostasis by attenuating adipose tissue inflammation in high fat diet fed mice.

Autor: Goand UK; Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Verma S; Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Gupta AP; Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India., Garg R; Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Dadge S; Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India., Gayen JR; Pharmaceutics & Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: jr.gayen@cdri.res.in.

Publikováno v: Peptides [Peptides] 2023 Jan; Vol. 159, pp. 170902. Date of Electronic Publication: 2022 Nov 11.

Pancreastatin inhibitor PSTi8 prevents free fatty acid-induced oxidative stress and insulin resistance by modulating JNK pathway: In vitro and in vivo findings.

Autor: Garg R; Pharmaceutics &Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Gupta AP; Pharmaceutics &Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India., Katekar R; Pharmaceutics &Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Verma S; Pharmaceutics &Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Goand UK; Pharmaceutics &Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India., Dadge S; Pharmaceutics &Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India., Gayen JR; Pharmaceutics &Pharmacokinetics, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Pharmacology Division, CSIR-Central Drug Research Institute, Jankipuram Extension, Lucknow 226031, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: jr.gayen@cdri.res.in.

Publikováno v: Life sciences [Life Sci] 2022 Jan 15; Vol. 289, pp. 120221. Date of Electronic Publication: 2021 Dec 10.