Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Go Fukui"'
Autor:
Yoko Sufu, Takuma Nanno, Xiaojuan Xu, Go Fukui, Hironori Ishiguchi, Masafumi Yano, Shigehiko Nishimura, Shinichi Okuda, Shigeki Kobayashi, Takeshi Yamamoto, Makoto Ono, Yoriomi Hamada, Yoshihide Nakamura, Tetsuro Oda, Michiaki Kohno, Takayoshi Kato
Publikováno v:
Heart Rhythm. 15:905-914
Background Ryanodine receptor (RyR2) is known to be a causal gene of catecholaminergic polymorphic ventricular tachycardia (CPVT), an important inherited disease. Some of the human CPVT-associated mutations have been found in a domain (4026-4172) tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e626ccdc31f2c2264d792965650da5f
https://doi.org/10.1016/j.hrthm.2018.02.006
https://doi.org/10.1016/j.hrthm.2018.02.006
Autor:
Masafumi Yano, Hitoshi Uchinoumi, Tetsuro Oda, Xiaojuan Xu, Go Fukui, Shinichi Okuda, Shigehiko Nishimura, Shigeki Kobayashi, Yoriomi Hamada, Takeshi Yamamoto, Masaki Tamitani, Yoshihide Nakamura, Takayoshi Kato
Publikováno v:
Circulation Research. 125
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by a single point mutation in the cardiac type 2 ryanodine receptor (RyR2). Using knock-in mouse (KI) model (R2474S/+), we previously reported that a single point mutation within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537c9aea21aae7c306d3bf4af58bc906
https://doi.org/10.1161/res.125.suppl_1.238
https://doi.org/10.1161/res.125.suppl_1.238
Autor:
Xiaojuan Xu, Tetsuro Oda, Yoshihide Nakamura, Hitoshi Uchinoumi, Shinichi Okuda, Takayoshi Kato, Yoriomi Hamada, Go Fukui, Shigeki Kobayashi, Masafumi Yano, Shigehiko Nishimura, Takeshi Yamamoto, Masaki Tamitani
Publikováno v:
JCI insight. 4(11)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is caused by a single point mutation in the cardiac type 2 ryanodine receptor (RyR2). Using a knockin (KI) mouse model (R2474S/+), we previously reported that a single point mutation within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472eb9f67a85ae20827039469592bcba
https://pubmed.ncbi.nlm.nih.gov/31167968
https://pubmed.ncbi.nlm.nih.gov/31167968
Autor:
Takayoshi Kato, Go Fukui, Yoriomi Hamada, Donald M. Bers, Shinichi Okuda, Yoshihide Nakamura, Yoko Okamoto, Hitoshi Uchinoumi, Masafumi Yano, Takeshi Yamamoto, Tetsuro Oda, Michiaki Kono, Takuma Nanno, Shigeki Kobayashi, Hironori Ishiguchi
Publikováno v:
Journal of molecular and cellular cardiology. 125
In cardiac myocytes Calmodulin (CaM) bound to the ryanodine receptor (RyR2) constitutes a large pool of total myocyte CaM, but the CaM-RyR2 affinity is reduced in pathological conditions. Knock-in mice expressing RyR2 unable to bind CaM also develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac7fc3beb06cfa8dab006174122bd82
https://pubmed.ncbi.nlm.nih.gov/30359562
https://pubmed.ncbi.nlm.nih.gov/30359562
Autor:
Xiaojuan Xu, Shinichi Okuda, Masakazu Fukuda, Yoshihide Nakamura, Hiroyuki Kyushiki, Hironori Ishiguchi, Akihiro Hino, Wakako Murakami, Takako Maeda, Makoto Ono, Tetsuro Oda, Takeshi Yamamoto, Yoriomi Hamada, Noritaka Koseki, Shigeki Kobayashi, Masafumi Yano, Takuma Nanno, Takayoshi Kato, Go Fukui, Shigehiko Nishimura, Yoko Sufu
Publikováno v:
Heart rhythm. 14(1)
Background Calmodulin (CaM) is a key modulator of the channel gating function of the ryanodine receptor (RyR). Objective The purpose of this study was to investigate the pathogenic role of RyR-bound CaM in diastolic Ca 2+ leakage from the sarcoplasmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4cea27596e66ede4fbd9d89662ca7e
https://pubmed.ncbi.nlm.nih.gov/27771553
https://pubmed.ncbi.nlm.nih.gov/27771553
Autor:
Go Fukui, Mamoru Mochizuki, Shigehiko Nishimura, Tetsuro Oda, Shinichi Okuda, Masafumi Yano, Akihiro Hino, Takako Maeda, Makoto Ono, Shigeki Kobayashi, Takeshi Suetomi, Takeshi Yamamoto
Publikováno v:
Circulation. 132
Introduction: We have been previously reported that calmodulin (CaM) binding affinity to RyR2 decreases upon beta stimulation in catecholaminergic polymorphic ventricular tachycardia (CPVT) type knock-in mice with mutation at central domain (R2474S-K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::725012486ef211447ab6121e791d1710
https://doi.org/10.1161/circ.132.suppl_3.13700
https://doi.org/10.1161/circ.132.suppl_3.13700
Autor:
Shigeki Kobayashi, Shinichi Okuda, Makoto Ono, Masafumi Yano, Tetsuro Oda, Akihiro Hino, Takako Maeda, Takayoshi Kato, Go Fukui, Shigehiko Nishimura, Takeshi Suetomi, Mamoru Mochizuki, Takeshi Yamamoto
Publikováno v:
Circulation. 132
Background: We have been reported that dantrolene (DAN) binds to N-terminal domain of the cardiac ryanodine receptor (RyR2) and corrects the aberrant Ca 2+ leak. We have been also reported that DAN enhances binding affinity of Calmodulin (CaM) to RyR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e805f127349d1cca4e8c6e9dafc62e17
https://doi.org/10.1161/circ.132.suppl_3.14991
https://doi.org/10.1161/circ.132.suppl_3.14991
Autor:
Masafumi Yano, Go Fukui, Shigeki Kobayashi, Yoshihide Nakamura, Shinichi Okuda, Takeshi Yamamoto, Tetsuro Oda
Publikováno v:
Journal of Cardiac Failure. 23:S41
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a7287c420d3fb260ddda7db41559a1f
https://doi.org/10.1016/j.cardfail.2017.08.190
https://doi.org/10.1016/j.cardfail.2017.08.190
Autor:
Takayoshi Kato, Shigeki Kobayashi, Shinichi Okuda, Go Fukui, Masafumi Yano, Shigehiko Nishimura, Takeshi Yamamoto, Tetsuro Oda
Publikováno v:
Journal of Cardiac Failure. 22:S207
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfddf47124a3cd1ba3cd288cb159ecea
https://doi.org/10.1016/j.cardfail.2016.07.286
https://doi.org/10.1016/j.cardfail.2016.07.286