Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Gösta Eggertsen"'
Publikováno v:
Adipocyte, Vol 9, Iss 1, Pp 587-599 (2020)
The aim of this study was to elucidate mechanisms whereby bile acids exert beneficial metabolic effects, using the Cyp8b1−/- mouse as model. These mice are unable to synthesize cholic acid, resulting in increased synthesis of chenodeoxycholic acid
Externí odkaz:
https://doaj.org/article/9549d762753c455fb19f23e46f6507ca
Autor:
Joel Marmur, Soheir Beshara, Gösta Eggertsen, Liselotte Onelöv, Nils Albiin, Olof Danielsson, Rolf Hultcrantz, Per Stål
Publikováno v:
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-10 (2018)
Abstract Background One-third of patients with non-alcoholic fatty liver disease (NAFLD) develop dysmetabolic iron overload syndrome (DIOS), the pathogenesis of which is unknown. Altered production of the iron-regulatory peptide hepcidin has been rep
Externí odkaz:
https://doaj.org/article/397e4ead4ff2477e8832cf382d266076
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 2, Pp 455-459 (2017)
We confirmed previous findings by a Japanese group that there is an accumulation of 7α-hydroxy-3-oxo-4-cholestenoic acid (7-Hoca) in human subdural hematomas. The accumulation correlated with the time from the bleeding to the sample collection. We p
Externí odkaz:
https://doaj.org/article/b9a3f79858e14db88ea92533aa574d91
Autor:
Kerstin Sandholm, Barbro Persson, Lillemor Skattum, Gösta Eggertsen, Dag Nyman, Iva Gunnarsson, Elisabet Svenungson, Bo Nilsson, Kristina N. Ekdahl
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Objectives: C1q is a valuable biomarker of disease activity in systemic lupus erythematosus (SLE). The “gold standard” assay, rocket immunoelectrophoresis (RIE), is time-consuming, and thus a shift to soluble immune precipitation techniques such
Externí odkaz:
https://doaj.org/article/18d39d4bf9dd4266bab7a5b0edc47e66
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147772 (2016)
High endogenous production of, or treatment with muricholic bile acids, strongly reduces the absorption of cholesterol. Mice abundant in muricholic bile acids may therefore display an increased resistance against dietary induced weight gain, steatosi
Externí odkaz:
https://doaj.org/article/3bbe3b6fdb3e48ff8d68b3bb273dc0b9
Autor:
Katharina Slätis, Mats Gåfvels, Kristina Kannisto, Olga Ovchinnikova, Gabrielle Paulsson-Berne, Paolo Parini, Zhao-Yan Jiang, Gösta Eggertsen
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 11, Pp 3289-3298 (2010)
To investigate the effects of abolished cholic acid (CA) synthesis in the ApoE knockout model [apolipoprotein E (apoE) KO],a double-knockout (DKO) mouse model was created by crossbreeding Cyp8b1 knockout mice (Cyp8b1 KO), unable to synthesize the pri
Externí odkaz:
https://doaj.org/article/2a42163791864cfeb2ef25f6ea7011bc
Autor:
Zhao-Yan Jiang, Paolo Parini, Gösta Eggertsen, Matthew A. Davis, Hai Hu, Guang-Jun Suo, Sheng-Dao Zhang, Lawrence L. Rudel, Tian-Quan Han, Curt Einarsson
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 2, Pp 464-472 (2008)
Cholesterol supersaturation of bile is one prerequisite for gallstone formation. In the present study of Chinese patients with gallstones, we investigated whether this phenomenon was correlated with the hepatic expression of genes participating in th
Externí odkaz:
https://doaj.org/article/7f522de2e8494048a66062268289074e
Autor:
Ephraim Sehayek, Lee R. Hagey, Yee-Yan Fung, Elizabeth M. Duncan, Hannah J. Yu, Gösta Eggertsen, Ingemar Björkhem, Alan F. Hofmann, Jan L. Breslow
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 9, Pp 2020-2027 (2006)
An intercross between C57BL/6J and CASA/Rk mice was used to study the genetics of biliary bile acid composition. In parental strains, male C57BL/6J mice had significantly higher cholic acid (CA; 14%) and lower β-muricholic acid (βMC; 27%) than CASA
Externí odkaz:
https://doaj.org/article/d1aa8ae5867a44ae853af8cdf3ad74eb
Autor:
Yusuke Inoue, Ai-Ming Yu, Sun Hee Yim, Xiaochao Ma, Kristopher W. Krausz, Junko Inoue, Charlie C. Xiang, Michael J. Brownstein, Gösta Eggertsen, Ingemar Björkhem, Frank J. Gonzalez
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 1, Pp 215-227 (2006)
Hepatocyte nuclear factor 4α (HNF4α) regulates many genes that are preferentially expressed in liver. Mice lacking hepatic expression of HNF4α (HNF4αΔL) exhibited markedly increased levels of serum bile acids (BAs) compared with HNF4α-floxed (H
Externí odkaz:
https://doaj.org/article/2e0d84da66da4c6894602d2415ebe533
Autor:
Lionel Bretillon, Dieter Lütjohann, Lars Ståhle, Torulf Widhe, Lutz Bindl, Gösta Eggertsen, Ulf Diczfalusy, Ingemar Björkhem
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 5, Pp 840-845 (2000)
We have previously presented evidence that most of the 24S-hydroxycholesterol present in the circulation originates from the brain and that most of the elimination of this oxysterol occurs in the liver. Plasma 24S-hydroxycholesterol levels decline by
Externí odkaz:
https://doaj.org/article/26e854ab1b6348b9b6a24c1054aa50ad