Zobrazeno 1 - 10
of 225
pro vyhledávání: '"Gökhan S. Hotamisligil"'
Autor:
Kacey J. Prentice, Alexandra Lee, Paulina Cedillo, Karen E. Inouye, Meric Erikci Ertunc, Jillian K. Riveros, Grace Yankun Lee, Gökhan S. Hotamisligil
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 6, Pp 100386- (2023)
Levels of circulating fatty acid binding protein 4 (FABP4) protein are strongly associated with obesity and metabolic disease in both mice and humans, and secretion is stimulated by β-adrenergic stimulation both in vivo and in vitro. Previously, lip
Externí odkaz:
https://doaj.org/article/3ef691986e5349e7918aa21ead105e98
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 4, Pp 734-740 (2019)
Although counterregulatory hormones and mediators of the fight-or-flight responses are well defined at many levels, how energy stores per se are integrated into this system remains an enigmatic question. Recent years have seen the adipose tissue beco
Externí odkaz:
https://doaj.org/article/013fa6ce80a9465f8d991436af1544dd
Autor:
Khanichi N. Charles, Min-Dian Li, Feyza Engin, Ana Paula Arruda, Karen Inouye, Gökhan S. Hotamisligil
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 393-402 (2017)
Summary: Deterioration of metabolic health is a hallmark of aging and generally assumed to be detrimental to longevity. Exposure to a high-calorie diet impairs metabolism and accelerates aging; conversely, calorie restriction (CR) prevents age-relate
Externí odkaz:
https://doaj.org/article/10f37773f5ae412db8a0de986dbdafef
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 12, Pp 2099-2114 (2016)
Lipids encompass a wide variety of molecules such as fatty acids, sterols, phospholipids, and triglycerides. These molecules represent a highly efficient energy resource and can act as structural elements of membranes or as signaling molecules that r
Externí odkaz:
https://doaj.org/article/405b696f45d34bb19e08d8a31f848549
Autor:
Ling Yang, Danilo Licastro, Edda Cava, Nicola Veronese, Francesco Spelta, Wanda Rizza, Beatrice Bertozzi, Dennis T. Villareal, Gökhan S. Hotamisligil, John O. Holloszy, Luigi Fontana
Publikováno v:
Cell Reports, Vol 14, Iss 3, Pp 422-428 (2016)
Calorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum corticosterone and HSP70 expression in rodents. However, less is known regarding the effects of CR on these factors in humans. Serum cortisol and molecular c
Externí odkaz:
https://doaj.org/article/e75edb8357a9404cb260dbdd272cd458
Autor:
Takahisa Nakamura, Ryan C. Kunz, Cai Zhang, Taishi Kimura, Celvie L. Yuan, Brenna Baccaro, Yuka Namiki, Steven P. Gygi, Gökhan S. Hotamisligil
Publikováno v:
Cell Reports, Vol 11, Iss 2, Pp 295-307 (2015)
Aberrant stress and inflammatory responses are key factors in the pathogenesis of obesity and metabolic dysfunction, and the double-stranded RNA-dependent kinase (PKR) has been proposed to play an important role in integrating these pathways. Here, w
Externí odkaz:
https://doaj.org/article/317f8e3d842c4ff381a6c698c808cbdc
Autor:
Meric Erikci Ertunc, Jørgen Sikkeland, Federico Fenaroli, Gareth Griffiths, Mathew P. Daniels, Haiming Cao, Fahri Saatcioglu, Gökhan S. Hotamisligil
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 2, Pp 423-434 (2015)
Adipocyte fatty acid binding protein 4, aP2, contributes to the pathogenesis of several common diseases including type 2 diabetes, atherosclerosis, fatty liver disease, asthma, and cancer. Although the biological functions of aP2 have classically bee
Externí odkaz:
https://doaj.org/article/9f1e3314f5c442ee9235510b0845a157
Autor:
Margaret F. Gregor, Emily S. Misch, Ling Yang, Sarah Hummasti, Karen E. Inouye, Ann-Hwee Lee, Brian Bierie, Gökhan S. Hotamisligil
Publikováno v:
Cell Reports, Vol 3, Iss 5, Pp 1430-1439 (2013)
The adipocyte is central to organismal metabolism and exhibits significant functional and morphological plasticity during its formation and lifespan. Remarkable transformations of this cell occur during obesity and lactation, and thus it is essential
Externí odkaz:
https://doaj.org/article/e1c71688bbd64649ae0d9d57855d504a
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 9, Pp 1905-1914 (2007)
In the context of obesity and its related maladies, the adipocyte plays a central role in the balance, or imbalance, of metabolic homeostasis. An obese, hypertrophic adipocyte is challenged by many insults, including surplus energy, inflammation, ins
Externí odkaz:
https://doaj.org/article/f918f8ffad05405ea3ff058b05a52bf6
Publikováno v:
PLoS ONE, Vol 4, Iss 1 (2009)
Externí odkaz:
https://doaj.org/article/5aa2eae3b68e4d41a485faead5f356bf