Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Go, Sugahara"'
Autor:
Kihak Gwon, Daheui Choi, José M. de Hoyos-Vega, Harihara Baskaran, Alan M. Gonzalez-Suarez, Seonhwa Lee, Hye Jin Hong, Kianna M. Nguyen, Ether Dharmesh, Go Sugahara, Yuji Ishida, Takeshi Saito, Gulnaz Stybayeva, Alexander Revzin
Publikováno v:
Bioactive Materials, Vol 28, Iss , Pp 183-195 (2023)
The ability to maintain functional hepatocytes has important implications for bioartificial liver development, cell-based therapies, drug screening, and tissue engineering. Several approaches can be used to restore hepatocyte function in vitro, inclu
Externí odkaz:
https://doaj.org/article/249a633d3371400dad06b02aeb3413a6
Autor:
Takeshi Chida, Yuji Ishida, Sho Morioka, Go Sugahara, Christine Han, Bill Lam, Chihiro Yamasaki, Remi Sugahara, Meng Li, Yasuhito Tanaka, T. Jake Liang, Chise Tateno, Takeshi Saito
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Hepatitis delta virus (HDV), a satellite virus of HBV, is regarded as the most severe type of hepatitis virus because of the substantial morbidity and mortality. The IFN system is the first line of defense against viral infections and an essential el
Externí odkaz:
https://doaj.org/article/608b3b9284e2485ab23afc6503eddeab
Autor:
Montserrat A. de la Rosa Rodriguez, Go Sugahara, Guido J. E. J. Hooiveld, Yuji Ishida, Chise Tateno, Sander Kersten
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background The role of PPARα in gene regulation in mouse liver is well characterized. However, less is known about the role of PPARα in human liver. The aim of the present study was to better characterize the impact of PPARα activation on
Externí odkaz:
https://doaj.org/article/3002e9bc15314a328ef2addfdebb3e67
Autor:
Keishi Kisoh, Go Sugahara, Yuko Ogawa, Suzue Furukawa, Yuji Ishida, Takeshi Okanoue, Michinori Kohara, Chise Tateno
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1647 (2021)
Nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) is the most common liver disorder in developed countries. Although many new therapeutics for NASH are present in the drug development pipeline, there are still no approved drugs. One of th
Externí odkaz:
https://doaj.org/article/65006a448cac4620b052520da4f8a0a4
Autor:
Yuji Ishida, Ami Yanagi, Chihiro Yamasaki, Go Sugahara, Yuko Ogawa, Shin Enosawa, Akihiro Umezawa, Akinari Fukuda, Suzue Furukawa, Chise Tateno
Publikováno v:
Journal of Inherited Metabolic Disease
Ornithine transcarbamylase deficiency (OTCD) is a metabolic and genetic disease caused by dysfunction of the hepatocytic urea cycle. To develop new drugs or therapies for OTCD, it is ideal to use models that are more closely related to human metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e262897e02b8130796fb054fcd0cf30
https://doi.org/10.1002/jimd.12347
https://doi.org/10.1002/jimd.12347
Autor:
Go Sugahara, Yuji Ishida, Jae Jin Lee, Meng Li, Yasuhito Tanaka, Hyungjin Eoh, Yusuke Higuchi, Takeshi Saito
Publikováno v:
FASEB Journal; Feb2023, Vol. 37 Issue 2, p1-17, 17p
Autor:
Kunpeng Hu, Arun J. Sanyal, Katherine Marx, Ramon Bataller, Stephanie Tran, Margery A. Connelly, Huimei Cai, Kenneth J. Mukamal, Karan Mathur, Michelle Lai, Eduardo Vilar, Esther Bullitt, Joana Vieira Barbosa, Hanchang He, Irina Shalaurova, Nezam H. Afdhal, Gyongyi Szabo, Raza Malik, Naga Chalasani, Michael P. Curry, Lee Landeen, Yury Popov, Zachary P. Fricker, Yusuf Yalcin, Sebastian Niezen, Takeshi Saito, Huiyan Deng, Go Sugahara, James D. Otvos, Josepmaria Argemi, Meritxell Ventura-Cots, Z. Gordon Jiang, Ang Lay-Hong, Maria Camila Perez-Matos, Aniket Gad, Sofia Izunza Barba
Publikováno v:
Hepatology (Baltimore, Md.). 75(4)
Background & aims Lipoprotein Z (LP-Z) is an abnormal free cholesterol (FC)-enriched low density lipoprotein (LDL)-like particle discovered from patients with cholestatic liver disease. This study aims to define the diagnostic value of LP-Z in alcoho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c010ca6281406e6cf59251179e5c541
https://pubmed.ncbi.nlm.nih.gov/34662439
https://pubmed.ncbi.nlm.nih.gov/34662439
Autor:
Michael Gale, Takeshi Saito, Daryl T.-Y. Lau, Bo-Ram Bang, Go Sugahara, Meng Li, Masakazu Kakuni, Chise Tateno-Mukaidani, Yuji Ishida
Publikováno v:
Journal of Interferon & Cytokine Research. 39:133-146
Interferons (IFNs) suppress viral infection through the induction of >400 interferon-stimulated genes (ISGs). Among ISGs, IFN-induced protein with tetratricopeptide repeats (IFITs) is one of the most potent and well-characterized ISGs. IFIT family co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c602bedb23c8814ddf17725d76f001de
https://doi.org/10.1089/jir.2018.0103
https://doi.org/10.1089/jir.2018.0103
Publikováno v:
Semin Liver Dis
Advancement in both bioengineering and cell biology of the liver led to the establishment of the first-generation humanized liver chimeric mouse (HLCM) model in 2001. The HLCM system was initially developed to satisfy the necessity for a convenient a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8102f0a1353d3a63bec776e430703db1
https://pubmed.ncbi.nlm.nih.gov/32074631
https://pubmed.ncbi.nlm.nih.gov/32074631
Autor:
Kazumi Sugihara, Yoshitaka Tayama, Yaichiro Kotake, Mineko Terao, Katsuhiro Okuda, Shigeru Ohta, Naoki Takaoka, Seigo Sanoh, Shigeyuki Kitamura, Go Sugahara, Chise Tateno, Enrico Garattini, Ami Yanagi, Mami Kurosaki, Yuji Ishida
Publikováno v:
Biochemical Pharmacology. 154:28-38
As aldehyde oxidase (AOX) plays an emerging role in drug metabolism, understanding its significance for drug–drug interactions (DDI) is important. Therefore, we tested 10 compounds for species-specific and substrate-dependent differences in the inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7314a9da94e03a427ea92dece402b9b
https://doi.org/10.1016/j.bcp.2018.04.017
https://doi.org/10.1016/j.bcp.2018.04.017